Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yassamin J. Safiran"'
Autor:
Christy A. Sasiela, Yili Yang, David Stewart, Jirouta Kitagaki, Pankaj Oberoi, John A. Beutler, Yassamin J. Safiran, Ilia Davydov, Allan M. Weissman, James B. McMahon, Barry R. O'Keefe, Ekaterina I. Goncharova
Publikováno v:
SLAS Discovery. 13:229-237
High-throughput screening technologies have revolutionized the manner in which potential therapeutics are identified. Although they are the source of lead compounds for ~65% of anticancer and antimicrobial drugs approved by the Food and Drug Administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fce1245c3464046236bdf198b94b244
https://doi.org/10.1177/1087057108315038
https://doi.org/10.1177/1087057108315038
Publikováno v:
Blood. 96:2841-2848
The malignant Reed-Sternberg cell of Hodgkin disease is an aberrant B cell that persists in an immunolgically mediated inflammatory infiltrate. Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the usual apoptotic fate of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0a7a36ddfad877137a3bbde0c23653
https://doi.org/10.1182/blood.v96.8.2841.h8002841_2841_2848
https://doi.org/10.1182/blood.v96.8.2841.h8002841_2841_2848
Autor:
Ilia V, Davydov, John H, Kenten, Yassamin J, Safiran, Stefanie, Nelson, Ryan, Swenerton, Pankaj, Oberoi, Hans A, Biebuyck
Publikováno v:
Methods in enzymology. 399
We describe a systematic, high-throughput approach to the discovery of protein substrates of ubiquitylation. This method uses a library of cDNAs in combination with a reticulocyte lysate-based, transcription-translation system that acts as both an ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::813bc5a44d6374f2f32352d3b0fd4dbb
https://pubmed.ncbi.nlm.nih.gov/16338373
https://pubmed.ncbi.nlm.nih.gov/16338373
Autor:
John H, Kenten, Ilia V, Davydov, Yassamin J, Safiran, David H, Stewart, Pankaj, Oberoi, Hans A, Biebuyck
Publikováno v:
Methods in enzymology. 399
We developed a series of assays for biochemical activities involving ubiquitin. These assays use electrochemiluminescence detection to measure the ubiquitylation of target proteins. To enable electrochemiluminescence detection, the target proteins we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9061fd32fc472e5bb0e4928e8463174c
https://pubmed.ncbi.nlm.nih.gov/16338389
https://pubmed.ncbi.nlm.nih.gov/16338389
Autor:
Allan M. Weissman, Pankaj Oberoi, Howard O. Fearnhead, Shengyun Fang, D. Woods, Jane P. Jensen, Yassamin J. Safiran, J. H. Kenten, Karen H. Vousden, Ilia Davydov
Publikováno v:
Journal of biomolecular screening. 9(8)
An assay for the autoubiquitination activity of the E3 ligase HDM2 (Mdm2) was developed and adapted to a high-throughput format to identify inhibitors of this activity. The assay can also be used to measure the activity of other E3s and may be useful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670d95a7a844be971c95fb29f22d6ad6
https://pubmed.ncbi.nlm.nih.gov/15634796
https://pubmed.ncbi.nlm.nih.gov/15634796
Autor:
Ilia Davydov, Hans A. Biebuyck, John H. Kenten, Pankaj Oberoi, Ryan K. Swenerton, Yassamin J. Safiran, Stefanie Nelson
We describe a systematic, high-throughput approach to the discovery of protein substrates of ubiquitylation. This method uses a library of cDNAs in combination with a reticulocyte lysate-based, transcription-translation system that acts as both an ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad10bd9077d5f741646953da57510be
https://doi.org/10.1016/s0076-6879(05)99029-0
https://doi.org/10.1016/s0076-6879(05)99029-0
Autor:
Pankaj Oberoi, John H. Kenten, Yassamin J. Safiran, David Stewart, Hans A. Biebuyck, Ilia Davydov
Publikováno v:
Methods in Enzymology ISBN: 9780121828042
We developed a series of assays for biochemical activities involving ubiquitin. These assays use electrochemiluminescence detection to measure the ubiquitylation of target proteins. To enable electrochemiluminescence detection, the target proteins we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee642537d901faf1a3deb583a9d6da19
https://doi.org/10.1016/s0076-6879(05)99045-9
https://doi.org/10.1016/s0076-6879(05)99045-9
Autor:
Allan M. Weissman, Robert L. Ludwig, Pankaj Oberoi, Jane P. Jensen, Yili Yang, John H. Kenten, Maxine V. Medaglia, Yassamin J. Safiran, Andrew C. Phillips, Shervon A. Pierre, Karen H. Vousden, Ilia Davydov
Publikováno v:
Cancer cell. 7(6)
SummaryThe p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as a ubiquitin ligase (E3) to target p53 for degradation. We have identified a family of small molecules (HLI98) that inhibits HDM2’s E3 activity. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b742bd19f74b14d7520cad4843988e3
https://pubmed.ncbi.nlm.nih.gov/15950904
https://pubmed.ncbi.nlm.nih.gov/15950904