Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Yasodha Krishnasamy"'
Autor:
Yasodha Krishnasamy, Venkat K Ramshesh, Monika Gooz, Rick G Schnellmann, John J Lemasters, Zhi Zhong
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163342 (2016)
BACKGROUND AND AIM:Because ethanol consumption is commonly associated with a high cholesterol diet, we examined whether combined consumption of ethanol and high cholesterol increases liver injury and fibrosis. METHODS:Male C57BL/6J mice were fed diet
Externí odkaz:
https://doaj.org/article/639a8c05f88f465b82ac6fbb85f579cf
Autor:
Qinlong Liu, Yasodha Krishnasamy, Hasibur Rehman, John J Lemasters, Rick G Schnellmann, Zhi Zhong
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140906 (2015)
BACKGROUND:Suppressed mitochondrial biogenesis (MB) contributes to acute kidney injury (AKI) after many insults. AKI occurs frequently after liver transplantation (LT) and increases mortality. This study investigated whether disrupted mitochondrial h
Externí odkaz:
https://doaj.org/article/c9679108cece467a8597f17d8c3591a2
Autor:
Hasibur Rehman, Yasodha Krishnasamy, Khujista Haque, Ronald G Thurman, John J Lemasters, Rick G Schnellmann, Zhi Zhong
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65029 (2014)
Our previous studies showed that an extract from Camellia sinenesis (green tea), which contains several polyphenols, attenuates nephrotoxicity caused by cyclosporine A (CsA). Since polyphenols are stimulators of mitochondrial biogenesis (MB), this st
Externí odkaz:
https://doaj.org/article/ad71d200438b40a7ae923c0cdc9b1c11
Autor:
Zhi Zhong, Venkat K Ramshesh, Hasibur Rehman, Qinlong Liu, Tom P Theruvath, Yasodha Krishnasamy, John J Lemasters
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91308 (2014)
An increase of ethanol metabolism and hepatic mitochondrial respiration occurs in vivo after a single binge of alcohol. Here, our aim was to determine how ethanol intake affects hepatic mitochondrial polarization status in vivo in relation to ethanol
Externí odkaz:
https://doaj.org/article/f2ba8228ba414d938af4c0bc8bd1186c
Autor:
Qinlong Liu, Hasibur Rehman, Yanjun Shi, Yasodha Krishnasamy, John J Lemasters, Charles D Smith, Zhi Zhong
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41834 (2012)
Inflammation mediates/promotes graft injury after liver transplantation (LT). This study investigated the roles of sphingosine kinase-2 (SK2) in inflammation after LT. Liver grafts were stored in UW solution with and without ABC294640 (100 µM), a se
Externí odkaz:
https://doaj.org/article/830a3023f4ab4923ad2aaebcaacf3905
Publikováno v:
RPS Pharmacy and Pharmacology Reports. 2
Objectives Some histone deacetylase (HDAC) isoforms contribute to ischaemia/reperfusion (IR) injury (IRI). Here, we examined whether LP342, the lead candidate of a new generation of hydrazide-based HDAC inhibitors (HDACi), decreases hepatic IRI. Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c0fb7bbb30f06bada8004a9d86270c9
https://doi.org/10.1093/rpsppr/rqad013
https://doi.org/10.1093/rpsppr/rqad013
Autor:
Devadoss J. Samuvel, Li Li, Yasodha Krishnasamy, Monika Gooz, Kenji Takemoto, Patrick M. Woster, John J. Lemasters, Zhi Zhong
Publikováno v:
Autophagy
Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In Type 2, mitochondrial depolarization (mtDepo) initiates mitophagy to remove the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8141f0fc097af54a12d3b965df525c78
https://europepmc.org/articles/PMC9629059/
https://europepmc.org/articles/PMC9629059/
The pathogenesis of non-alcoholic steatohepatitis (NASH) is poorly understood. Here, relationships between mitochondrial depolarization (mtDepo) and mitochondrial homeostasis were studied in a mouse model of NASH. C57BL/6 mice were fed a Western diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4c374082b3906e9cde2a18d13ad53b32
https://europepmc.org/articles/PMC6872485/
https://europepmc.org/articles/PMC6872485/
Publikováno v:
International journal of physiology, pathophysiology and pharmacology. 10(2)
Pulmonary complications frequently occur after liver transplantation and are often life-threatening. Thus, we investigated whether hepatic ischemic preconditioning (IP) attenuates acute lung injury (ALI) after small-for-size liver transplantation. Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13ce176b5443c1634fa6b6b846d9fca6
https://pubmed.ncbi.nlm.nih.gov/29755641
https://pubmed.ncbi.nlm.nih.gov/29755641
Autor:
Yasodha Krishnasamy, John J. Lemasters, Rick G. Schnellmann, Qinlong Liu, Zhi Zhong, Hasibur Rehman
Publikováno v:
Journal of Hepatology. 63:68-74
Background & Aims: Inclusion of liver grafts from cardiac death donors (CDD) would increase the availability of donor livers but is hampered by a higher risk of primary non-function. Here, we seek to determine mechanisms that contribute to primary no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b17599a16bd74313e39453d3157e94
https://doi.org/10.1016/j.jhep.2015.02.017
https://doi.org/10.1016/j.jhep.2015.02.017