Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

Autor: Marie Nguyen, Adele De Ninno, Arianna Mencattini, Fanny Mermet-Meillon, Giulia Fornabaio, Sophia S. Evans, Mélissande Cossutta, Yasmine Khira, Weijing Han, Philémon Sirven, Floriane Pelon, Davide Di Giuseppe, Francesca Romana Bertani, Annamaria Gerardino, Ayako Yamada, Stéphanie Descroix, Vassili Soumelis, Fatima Mechta-Grigoriou, Gérard Zalcman, Jacques Camonis, Eugenio Martinelli, Luca Businaro, Maria Carla Parrini

Publikováno v: Cell Reports, Vol 25, Iss 13, Pp 3884-3893.e3 (2018)

Summary: A major challenge in cancer research is the complexity of the tumor microenvironment, which includes the host immunological setting. Inspired by the emerging technology of organ-on-chip, we achieved 3D co-cultures in microfluidic devices (in

Externí odkaz: https://doaj.org/article/1348722c708442c9936e214684b50064

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

Autor: Eugenio Martinelli, Luca Businaro, Vassili Soumelis, Ayako Yamada, Fanny Mermet-Meillon, Maria Carla Parrini, Weijing Han, Jacques Camonis, Floriane Pelon, Yasmine Khira, Giulia Fornabaio, Francesca Romana Bertani, Annamaria Gerardino, Gérard Zalcman, Stéphanie Descroix, Mélissande Cossutta, Marie Nguyen, Fatima Mechta-Grigoriou, Sophia S. Evans, Adele De Ninno, Davide Di Giuseppe, Philémon Sirven, Arianna Mencattini

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2018, 25 (13), pp.3884-3893.e3. ⟨10.1016/j.celrep.2018.12.015⟩
Cell reports 25 (2018): 3884–+. doi:10.1016/j.celrep.2018.12.015
info:cnr-pdr/source/autori:Nguyen, Marie; De Ninno, Adele; Mencattini, Arianna; Mermet-Meillon, Fanny; Fornabaio, Giulia; Evans, Sophia S.; Cossutta, Melissande; Khira, Yasmine; Han, Weijing; Sirven, Philemon; Pelon, Floriane; Di Giuseppe, Davide; Bertani, Francesca Romana; Gerardino, Annamaria; Yamada, Ayako; Descroix, Stephanie; Soumelis, Vassili; Mechta-Grigoriou, Fatima; Zalcman, Gerard; Camonis, Jacques; Martinelli, Eugenio; Businaro, Luca; Parrini, Maria Carla/titolo:Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments/doi:10.1016%2Fj.celrep.2018.12.015/rivista:Cell reports/anno:2018/pagina_da:3884/pagina_a:+/intervallo_pagine:3884–+/volume:25
Cell Reports, Vol 25, Iss 13, Pp 3884-3893.e3 (2018)

Summary: A major challenge in cancer research is the complexity of the tumor microenvironment, which includes the host immunological setting. Inspired by the emerging technology of organ-on-chip, we achieved 3D co-cultures in microfluidic devices (in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5529a83af8a1d14b9c9abf51bb3ce7b
https://doi.org/10.1016/j.celrep.2018.12.015