Systemic administration of Ivabradine, an HCN channel inhibitor, blocks spontaneous absence seizures

Autor: H. Rheinallt Parri, Christoffer Bundgaard, Johan Juhl Weisser, François David, Yasmine Iacone, Francis Delicata, Vincenzo Crunelli, M. Thomsen, Ib Vestergaard Klewe, Magor L. Lőrincz, Joanna Sandle, Tímea Raffai, Gábor Tamás, Tatiana P. Morais

SummaryObjectiveHyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to be involved in the generation of absence seizures (ASs), and there is evidence that cortical and thalamic HCN channel dysfunctions may have a pro-absence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16838e029a7141d82ef7fb347a316dba
https://doi.org/10.1101/2021.02.17.431588

Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability

Autor: Katia Fabiana Fera, Olivier Lequin, David Allsop, Jean-Louis Soulier, Benoit Crousse, Nicolo Tonali, Dimitri Brinet, Mark Taylor, Lucie Khemtémourian, Isabelle Correia, Anais R. F. Hoffmann, Sandrine Ongeri, Yasmine Iacone, Julia Kaffy, Myriam Taverna

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2016, 59 (5), pp.2025-2040. ⟨10.1021/acs.jmedchem.5b01629⟩
Journal of Medicinal Chemistry, American Chemical Society, 2016, 59 (5), pp.2025-2040. 〈10.1021/acs.jmedchem.5b01629〉
Journal of Medicinal Chemistry, 2016, 59 (5), pp.2025-2040. ⟨10.1021/acs.jmedchem.5b01629⟩

International audience; How anti-Alzheimer’s drug candidates that reduce amyloid 1–42 peptide fibrillization interact with the most neurotoxic species is far from being understood. We report herein the capacity of sugar-based peptidomimetics to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f19a813c4432451068411b21bbe840
https://hal.archives-ouvertes.fr/hal-01303733