Výsledky vyhledávání - "Yasmine, Baca"

Akademický článek

Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)

Abstract Homologous recombination (HR) and nucleotide excision repair (NER) are the two most frequently disabled DNA repair pathways in cancer. HR-deficient breast, ovarian, pancreatic and prostate cancers respond well to platinum chemotherapy and PA

Externí odkaz: https://doaj.org/article/b6b069037e684be89e6db272774fcef6

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Akademický článek

Comparative molecular profiling of pancreatic ductal adenocarcinoma of the head versus body and tail

Autor: Maen Abdelrahim, Abdullah Esmail, Anup Kasi, Nestor F. Esnaola, Joanne Xiu, Yasmine Baca, Benjamin A. Weinberg

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-8 (2024)

Abstract Pancreatic ductal adenocarcinoma (PDAC) of the head (H) and body/tail (B/T) differ in embryonic origin, cell composition, blood supply, lymphatic and venous drainage, and innervation. We aimed to compare the molecular and tumor immune microe

Externí odkaz: https://doaj.org/article/66e31730210d4f1785ac78732b4c510b

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Akademický článek

Differential landscape of immune evasion in oncogenic RAS-driven primary and metastatic colorectal cancers

Autor: Emil Lou, Joanne Xiu, Yasmine Baca, Anwaar Saeed, Ajay Prakash, Sepideh Gholami, Subbaya Subramanian, Timothy K. Starr, Elisa Fontana, Ritu Pandey, Heinz-Josef Lenz, Anthony F. Shields, Chadi Nabhan, Matthew Oberley, Andreas Seeber, Wafik El-Deiry

Publikováno v: Molecular Therapy: Oncology, Vol 32, Iss 1, Pp 200786- (2024)

Oncogenic drivers such as KRAS extensively modulate the tumor inflammatory microenvironment (TIME) of colorectal cancer (CRC). The influence of KRAS on modulating immune cell composition remains unclear. The objective of this study was to identify si

Externí odkaz: https://doaj.org/article/3eb19f3122a34991ab2796771ff9e257

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Akademický článek

Pan-tumor survey of ROS1 fusions detected by next-generation RNA and whole transcriptome sequencing

Autor: Misako Nagasaka, Shannon S. Zhang, Yasmine Baca, Joanne Xiu, Jorge Nieva, Ari Vanderwalde, Jeffrey J. Swensen, David Spetzler, Wolfgang Michael Korn, Luis E. Raez, Stephen V. Liu, Sai-Hong Ignatius Ou

Publikováno v: BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)

Abstract Background Two ROS1 tyrosine kinase inhibitors have been approved for ROS1 fusion positive (ROS1+) non-small cell lung cancer (NSCLC) tumors. We performed a pan-tumor analysis of the incidence of ROS1 fusions to assess if more ROS1+ patients

Externí odkaz: https://doaj.org/article/05a3d80854dc433ca5dd01303b8437af

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Akademický článek

PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system

Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)

Abstract Polybromo-1 (PBRM1) loss of function mutations are present in a fraction of biliary tract cancers (BTCs). PBRM1, a subunit of the PBAF chromatin-remodeling complex, is involved in DNA damage repair. Herein, we aimed to decipher the molecular

Externí odkaz: https://doaj.org/article/5241117531c4407f8106f8137c687dda

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Akademický článek

CCR5 and CCL5 gene expression in colorectal cancer: comprehensive profiling and clinical value

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)

Background The C-C motif chemokine receptor 5 (CCR5)/C-C motif chemokine ligand 5 (CCL5) axis plays a major role in colorectal cancer (CRC). We aimed to characterize the molecular features associated with CCR5/CCL5 expression in CRC and to determine

Externí odkaz: https://doaj.org/article/0070d43d733f41d1a13e1ef74847bb8d

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Akademický článek

Pan-tumor survey of RET fusions as detected by next-generation RNA sequencing identified RET fusion positive colorectal carcinoma as a unique molecular subset

Autor: Misako Nagasaka, Danielle Brazel, Yasmine Baca, Joanne Xiu, Mohammed Najeeb Al-Hallak, Chul Kim, Jorge Nieva, Jeffrey J. Swensen, David Spetzler, Wolfgang Michael Korn, Mark A. Socinski, Luis E. Raez, Balazs Halmos, Sai-Hong Ignatius Ou

Publikováno v: Translational Oncology, Vol 36, Iss , Pp 101744- (2023)

Background: RET fusions are driver alterations in cancer and are most commonly found in non-small cell lung cancer and well-differentiated thyroid cancer. However, RET fusion have been reported in other solid tumors. Material and methods: A retrospec

Externí odkaz: https://doaj.org/article/be4f08bbbeef4d4185ba93c951961543

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Abstract P4-08-06: Clock Genes in Breast Cancer

Publikováno v: Cancer Research. 83:P4-08

Background: Disruption of circadian processes has been linked to cancer initiation, progression, metastasis, resistance, and mortality. Clock proteins are an emerging target for therapy in breast cancer. Circadian rhythms are controlled by a network

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9610eb5d29863e7b6bc0981f90fbbc5
https://doi.org/10.1158/1538-7445.sabcs22-p4-08-06

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