Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders

Autor: Mònica Pardo, Sara Gregorio, Enrica Montalban, Lluís Pujadas, Alba Elias-Tersa, Núria Masachs, Alba Vílchez-Acosta, Annabelle Parent, Carme Auladell, Jean-Antoine Girault, Miquel Vila, Angus C. Nairn, Yasmina Manso, Eduardo Soriano

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder.

Externí odkaz: https://doaj.org/article/3cd3106052264619a64208bc8946f830

NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization

Autor: Francisco Freixo, Paula Martinez Delgado, Yasmina Manso, Carlos Sánchez-Huertas, Cristina Lacasa, Eduardo Soriano, Joan Roig, Jens Lüders

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

NEK7 is a kinase known for its role in mitotic spindle assembly, driving centrosome separation in prophase through regulation of the kinesin Eg5. Here, the authors show that NEK7 and Eg5 also control dendrite morphogenesis in postmitotic neurons.

Externí odkaz: https://doaj.org/article/053282e29ed4414bbaf05118740ff4ed

Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion.

Autor: Jamie McQueen, Michell M Reimer, Philip R Holland, Yasmina Manso, Mark McLaughlin, Jill H Fowler, Karen Horsburgh

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87227 (2014)

Chronic cerebral hypoperfusion, a sustained modest reduction in cerebral blood flow, is associated with damage to myelinated axons and cognitive decline with ageing. Oligodendrocytes (the myelin producing cells) and their precursor cells (OPCs) may b

Externí odkaz: https://doaj.org/article/2cb44815c5c14670820d6e19fbe5aa82

The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity

Autor: Aleix Gavaldà-Navarro, Serena Mirra, Yasmina Manso, David Sánchez-Infantes, Marta Giralt, Eduardo Soriano, Francesc Villarroya

Publikováno v: International Journal of Obesity
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
INTERNATIONAL JOURNAL OF OBESITY
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu

OBJECTIVES: To determine the role of armadillo repeat-containing X-linked protein 3 (ARMCX3) in the thermogenic plasticity of adipose tissue. METHODS: Adipose tissues were characterized in Armcx3-KO male mice. Armcx3 gene expression was analyzed in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc38ab51e30c462d25ccbffb82ba795
https://doi.org/10.1038/s41366-022-01169-1

Specific contribution of Reelin expressed by Cajal–Retzius cells or GABAergic interneurons to cortical lamination

Autor: Alba Vílchez-Acosta, Yasmina Manso, Adrián Cárdenas, Alba Elias-Tersa, Magdalena Martínez-Losa, Marta Pascual, Manuel Álvarez-Dolado, Angus C. Nairn, Víctor Borrell, Eduardo Soriano

Publikováno v: Proceedings of the National Academy of Sciences. 119

[Significance]: The present study highlights a fundamental role of GABAergic interneuron-derived Reelin in neuronal migration, in addition to CR cell–expressed Reelin. Further, we observed transient migratory deficits, indicating that Reelin expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3eb96ac7025af04469c60ffde7c9c0
https://doi.org/10.1073/pnas.2120079119