Výsledky vyhledávání - "Yasmina Adimy"

Clinical Pharmacology and Determinants of Response to UCART19, an Allogeneic Anti-CD19 CAR-T Cell Product, in Adult B-cell Acute Lymphoblastic Leukemia

Autor: Sandra Dupouy, Ibtissam Marchiq, Thibaud Derippe, Maria Almena-Carrasco, Agnieszka Jozwik, Sylvain Fouliard, Yasmina Adimy, Julia Geronimi, Charlotte Graham, Nitin Jain, Marcela V. Maus, Mohamad Mohty, Nicolas Boissel, Takanori Teshima, Koji Kato, Reuben Benjamin, Svetlana Balandraud

Publikováno v: Cancer Research Communications. 2:1520-1531

Background: UCART191 is an “off-the-shelf” genome-edited anti-CD19 chimeric antigen receptor (CAR)-T cell product, manufactured from unrelated healthy donor cells. Methods: UCART19 was administered to 25 adult patients with relapsed or refractory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::736f5fbb925378596fc9009322ee48d9
https://doi.org/10.1158/2767-9764.crc-22-0175

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Data from Clinical Pharmacology and Determinants of Response to UCART19, an Allogeneic Anti-CD19 CAR-T Cell Product, in Adult B-cell Acute Lymphoblastic Leukemia

Autor: Svetlana Balandraud, Reuben Benjamin, Koji Kato, Takanori Teshima, Nicolas Boissel, Mohamad Mohty, Marcela V. Maus, Nitin Jain, Charlotte Graham, Julia Geronimi, Yasmina Adimy, Sylvain Fouliard, Agnieszka Jozwik, Maria Almena-Carrasco, Thibaud Derippe, Ibtissam Marchiq, Sandra Dupouy

Background:UCART191 is an “off-the-shelf” genome-edited anti-CD19 chimeric antigen receptor (CAR)-T cell product, manufactured from unrelated healthy donor cells.Methods:UCART19 was administered to 25 adult patients with relapsed or refractory (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcd1a015588a32687c74ecd3850749d
https://doi.org/10.1158/2767-9764.c.6551198

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Supplementary Tables S1-S4 from Clinical Pharmacology and Determinants of Response to UCART19, an Allogeneic Anti-CD19 CAR-T Cell Product, in Adult B-cell Acute Lymphoblastic Leukemia

Table S1: Representativeness of CALM study participants; Table S2: UCART19 dose and cellular kinetics analysis; Table S3: Characteristics of UCART19 PBMC donors; Table S4: Impact of UCART19 and alemtuzumab doses on UCART19 expansion.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5604d0ed6171dc5e3b45d6c9b4633e69
https://doi.org/10.1158/2767-9764.22546532

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Supplementary Figures S1-S9 from Clinical Pharmacology and Determinants of Response to UCART19, an Allogeneic Anti-CD19 CAR-T Cell Product, in Adult B-cell Acute Lymphoblastic Leukemia

Fig.S1: Schematic diagram of CALM study design; Fig.S2: Correlation of UCART19 transgene levels evaluated by qPCR in paired peripheral blood and bone marrow aspirate samples; Fig.S3 & S4: Impact of demographic characteristics, prior therapies and tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45dd48bb94572046df7c90467ade853a
https://doi.org/10.1158/2767-9764.22546538

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Supplementary Materials & Methods SM1 from Clinical Pharmacology and Determinants of Response to UCART19, an Allogeneic Anti-CD19 CAR-T Cell Product, in Adult B-cell Acute Lymphoblastic Leukemia

Additional information regarding the CALM study (including study population and summary results) and UCART19 product characterization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59fcc1bd4d55374b407514575a4a3a1a
https://doi.org/10.1158/2767-9764.22546535.v1

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Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Autor: Yasmina Adimy, Christèle Combes, Hang-Korng Ea, Martine Cohen-Solal, Thomas Bardin, Jean-Pierre Riveline, Felix Renaudin, Lucie Orliaguet, Florence Castelli, Pascal Richette, Frédéric Lioté, François Fenaille, Nicolas Venteclef, Laure Campillo-Gimenez, Fawaz Alzaid, Aurélie Prignon, Aurélie Delvaux

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2020, 79 (11), pp.1506-1514. ⟨10.1136/annrheumdis-2020-217342⟩
Annals of the Rheumatic Diseases, 2020, 79 (11), pp.1506-1514. ⟨10.1136/annrheumdis-2020-217342⟩

ObjectiveMacrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, respectively. Since metabolic reprogramming of macrophages go

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc85ce496a2d99098e317f810d2250f
https://hal.archives-ouvertes.fr/hal-03203907

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