Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yasmin Shamsudin Khan"'
Publikováno v:
Biochemistry. 57:1236-1248
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) 1 and 2 with varying degrees of selectivity. A group of COX-2 selective inhibitors-coxibs-binds in a time-dependent manner through a three-step mechanism, utilizing a side poc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a630b463470e620f5f673e2b905357cf
https://doi.org/10.1021/acs.biochem.7b01019
https://doi.org/10.1021/acs.biochem.7b01019
Publikováno v:
Biochemistry. 56:1911-1920
Time-dependent inhibition of the cyclooxygenases (COX) by a range of nonsteroidal anti-inflammatory drugs has been described since the first experimental assays of COX were performed. Slow tight-binding inhibitors of COX-1 bind in a two-step mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee506ac3da379fdeab01bd0311aafb0c
https://doi.org/10.1021/acs.biochem.6b01006
https://doi.org/10.1021/acs.biochem.6b01006
Autor:
Mats Larhed, Karin Engen, Alfhild Grönbladh, Jonas Sävmarker, Mathias Hallberg, Shanti Diwakarla, Sofia Zelleroth, Erik Nylander, Siew Yeen Chai, Annika Jenmalm-Jensen, Yasmin Shamsudin Khan, Sudarsana Reddy Vanga, Vi Pham, Thomas Lundbäck, Leelee Ng, Per Artursson, Hugo Gutiérrez-de-Terán, Johan Åqvist, Richard Svensson, Ulrika Rosenström
Publikováno v:
ACS Chemical Neuroscience. 7:1383-1392
The zinc metallopeptidase insulin regulated aminopeptidase (IRAP), which is highly expressed in the hippocampus and other brain regions associated with cognitive function, has been identified as a high-affinity binding site of the hexapeptide angiote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f84bca4e17cc4040a5683411d085c54
https://doi.org/10.1021/acschemneuro.6b00146
https://doi.org/10.1021/acschemneuro.6b00146
Autor:
Hanna Andersson, Vi Pham, Hugo Gutiérrez-de-Terán, Shanti Diwakarla, Sudarsana Reddy Vanga, Annika Jenmalm-Jensen, Mats Larhed, Siew Yeen Chai, Jonas Sävmarker, Ulrika Rosenström, Mathias Hallberg, Yasmin Shamsudin Khan, Alfhild Grönbladh, Leelee Ng, Johan Åqvist, Karin Engen, Thomas Lundbäck, Erik Nylander
Publikováno v:
Molecular Pharmacology. 89:413-424
Angiotensin IV (Ang IV) and related peptide analogs, as well as nonpeptide inhibitors of insulin-regulated aminopeptidase (IRAP), have previously been shown to enhance memory and cognition in animal models. Furthermore, the endogenous IRAP substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b7b48526cabbfd1b4f3ae579bc073c
https://doi.org/10.1124/mol.115.102533
https://doi.org/10.1124/mol.115.102533
Publikováno v:
Journal of Chemical Information and Modeling. 54:1488-1499
Cyclooxygenase-1 (COX-1) is one of the main targets of most pain-relieving pharmaceuticals. Although the enzyme is well characterized, it is known to be a difficult target for automated molecular docking and scoring. We collected from the literature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b61b856b70e17ce15e62a6c7bf8044
https://doi.org/10.1021/ci500151f
https://doi.org/10.1021/ci500151f
Publikováno v:
Biochemistry. 54(49)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain, fever, inflammation, and some types of cancers. Their mechanism of action is the inhibition of isoforms 1 and 2 of the enzyme cyclooxygenase (COX-1 and COX-2, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9c7864d9162dfefd09aa7ce0b73fc7
https://pubmed.ncbi.nlm.nih.gov/26562384
https://pubmed.ncbi.nlm.nih.gov/26562384