Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans.

Autor: Jogchum Plat, Tim Hendrikx, Veerle Bieghs, Mike L J Jeurissen, Sofie M A Walenbergh, Patrick J van Gorp, Els De Smet, Maurice Konings, Anita C E Vreugdenhil, Yasmin Dias Guichot, Sander S Rensen, Wim A Buurman, Jan Willem M Greve, Dieter Lütjohann, Ronald P Mensink, Ronit Shiri-Sverdlov

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110758 (2014)

The inflammatory component of non-alcoholic steatohepatitis (NASH) can lead to irreversible liver damage. Therefore there is an urgent need to identify novel interventions to combat hepatic inflammation. In mice, omitting cholesterol from the diet re

Externí odkaz: https://doaj.org/article/9829ddc4e43d4ce98a44b98247c0e9a2

The Cholesterol Derivative 27-Hydroxycholesterol Reduces Steatohepatitis in Mice

Autor: Patrick J. van Gorp, Veerle Bieghs, Mike L. J. Jeurissen, Satish C. Kalhan, Ronit Sverdlov, Yasmin Dias Guichot, Sander S. Rensen, Jogchum Plat, Marion J.J. Gijbels, Aalt Bast, Eran Leitersdorf, Dieter Lütjohann, Marten H. Hofker, Ger H. Koek, Tim Hendrikx, Fons Verheyen, Sofie M. A. Walenbergh

Publikováno v: Gastroenterology, 144(1), 167-178.e1. Elsevier Saunders
Gastroenterology, 144(1), 167-178. W.B. Saunders Ltd
Gastroenterology, 144(1), 167-U291. W B SAUNDERS CO-ELSEVIER INC

Background & Aims Non-alcoholic steatohepatitis is characterized by hepatic steatosis with inflammation. Although steatosis is benign and reversible, inflammation can increase liver damage. Hepatic inflammation has been associated with accumulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246772c75320e660a7ce27952b283855
https://doi.org/10.1053/j.gastro.2012.09.062

Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr / mice

Autor: Dieter Lütjohann, Tim Hendrikx, Patrick J. van Gorp, Yasmin Dias Guichot, Tom Houben, Veerle Bieghs, Mike L. J. Jeurissen, Sofie M. A. Walenbergh, Fons Verheyen, Ronit Shiri-Sverdlov, Marten H. Hofker, Marion J.J. Gijbels, Eran Leitersdorf

Publikováno v: Scopus-Elsevier
Journal of Hepatology, 62(2), 430-436. Elsevier Science

Background & Aims: Non-alcoholic steatohepatitis (NASH) is characterized by hepatic lipid accumulation and inflammation. Currently, the underlying mechanisms, leading to hepatic inflammation, are still unknown. The breakdown of free cholesterol insid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b8fd712d7c0fda761b3d25b5fa0647
http://www.scopus.com/inward/record.url?eid=2-s2.0-84922246659&partnerID=MN8TOARS