Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yasmeen Sarfraz"'
Autor:
Claire Vanpouille-Box, Amandine Alard, Molykutty J. Aryankalayil, Yasmeen Sarfraz, Julie M. Diamond, Robert J. Schneider, Giorgio Inghirami, C. Norman Coleman, Silvia C. Formenti, Sandra Demaria
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Trex1 is an exonuclease that degrades cytosolic DNA and has been associated with modulation of interferon responses in autoimmunity and viral infections. Here, the authors show that Trex1 attenuates the immunogenicity of cancer cells treated with hig
Externí odkaz:
https://doaj.org/article/fbe7810370734d60b0bb36cf8cb9767e
Autor:
Sandra Demaria, Silvia C. Formenti, Yasmeen Sarfraz, Karsten A. Pilones, Beatrix M. Ueberheide, Jessica R. Chapman, Nils-Petter Rudqvist, Sheila Spada, Claire Vanpouille-Box, Julie M. Diamond
Proteomics profiles of UT-TEX and RT-TEX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dec2574efeb163d09bf462c47f23188
https://doi.org/10.1158/2326-6066.22539856.v1
https://doi.org/10.1158/2326-6066.22539856.v1
Data from Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs
Autor:
Sandra Demaria, Silvia C. Formenti, Yasmeen Sarfraz, Karsten A. Pilones, Beatrix M. Ueberheide, Jessica R. Chapman, Nils-Petter Rudqvist, Sheila Spada, Claire Vanpouille-Box, Julie M. Diamond
Radiotherapy (RT) used at immunogenic doses leads to accumulation of cytosolic double-stranded DNA (dsDNA) in cancer cells, which activates type I IFN (IFN-I) via the cGAS/STING pathway. Cancer cell–derived IFN-I is required to recruit BATF3-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e499c2643f1879d25a646d3fcca5921
https://doi.org/10.1158/2326-6066.c.6549199.v1
https://doi.org/10.1158/2326-6066.c.6549199.v1
Autor:
Gregg L. Semenza, David Zagzag, Makoto Suematsu, Lisha Xiang, Pallavi Chaturvedi, Daniele M. Gilkes, Yasmeen Sarfraz, Naoharu Takano
Supplementary Figure S1. Cell proliferation of U87-MG subclones in vitro. 5,000 cells were seeded and cultured under 20% or 1% O2. Viable cell number was counted by trypan blue staining on days 2, 3, and 4, and normalized to the starting cell number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4ac815d72fef7415ab317e32b2239d
https://doi.org/10.1158/1541-7786.22514200.v1
https://doi.org/10.1158/1541-7786.22514200.v1
Autor:
Yasmeen Sarfraz, Giorgio Inghirami, Silvia C. Formenti, Molykutty J. Aryankalayil, Sandra Demaria, C. Norman Coleman, Claire Vanpouille-Box, Robert J. Schneider, Julie M. Diamond, Amandine Alard
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiation doses abo
Autor:
Nils Rudqvist, Sheila Spada, Yasmeen Sarfraz, Karsten A. Pilones, Claire Vanpouille-Box, Silvia C. Formenti, Sandra Demaria, Julie M. Diamond, Jessica R. Chapman, Beatrix Ueberheide
Radiotherapy (RT) used at immunogenic doses leads to accumulation of cytosolic double-stranded DNA (dsDNA) in cancer cells, which activates type I IFN (IFN-I) via the cGAS/STING pathway. Cancer cell–derived IFN-I is required to recruit BATF3-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540ee630946b06286775eaab10ce8a90
https://europepmc.org/articles/PMC6072562/
https://europepmc.org/articles/PMC6072562/
Autor:
Valerio Ortenzi, Garry Douglas, Barbara Romagnoli, Yasmeen Sarfraz, Fawaz M. Alotaibi, Awab T. Tayyib, Luis Chiriboga, David Zagzag, Jean-Pierre Gagner, Guillaume Lemercier, Eric Chevalier, Klaus Dembowsky, Michel Schmitt, Gerald Tuffin
Resistance to antiangiogenic therapy in glioblastoma (GBM) patients may involve hypoxia-induced expression of C-X-C motif chemokine receptor 4 (CXCR4) on invading tumor cells, macrophage/microglial cells (MGCs), and glioma stem cells (GSCs). We deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427df2b12f9e81f1788e20147d820c2a
https://europepmc.org/articles/PMC5809520/
https://europepmc.org/articles/PMC5809520/
Publikováno v:
The Open Neuropsychopharmacology Journal. 5:9-17
A long standing problem with antidepressant drugs is their delayed onsets of action which has made them unsatisfactory in the rapid treatment of serious depressions involving agitated and suicidal behavior. Two new approaches to this problem involve
Autor:
Yasmeen Sarfraz, Jean-Pierre Gagner, Dimitris G. Placantonakis, Valerio Ortenzi, Luis Chiriboga, David Zagzag, N. Sumru Bayin
BACKGROUND: Long considered to be inert organelles for lipid storage, lipid droplets (LDs) have recently attracted great interest as dynamic structures central to cellular lipid and energy metabolism. hypoxia-inducible gene (HIG2) and perilipin 2 (PL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b065344bf0ced44a0e4fed646c303576
https://europepmc.org/articles/PMC4639304/
https://europepmc.org/articles/PMC4639304/
Publikováno v:
Brain Research Reviews. 67:193-208
Although the central noradrenergic system has been shown to be involved in a number of behavioral and neurophysiological processes, the relation of these to its role in depressive illness has been difficult to define. The present review discusses the