Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yasmeen N. Ruma"'
Publikováno v:
Journal of Structural Biology: X, Vol 10, Iss , Pp 100107- (2024)
Clostripain secreted from Clostridium histolyticum is the founding member of the C11 family of Clan CD cysteine peptidases, which is an important group of peptidases secreted by numerous bacteria. Clostripain is an arginine-specific endopeptidase. Be
Externí odkaz:
https://doaj.org/article/f8ebe8552c8544a8b6e77f0a351d2084
Publikováno v:
Journal of Fungi, Vol 8, Iss 12, p 1256 (2022)
Cryptococcus remains a leading cause of invasive fungal infections in immunocompromised people. Resistance to azole drugs has imposed a further challenge to the effective treatment of such infections. In this study, the functional expression of full-
Externí odkaz:
https://doaj.org/article/e9dbbfb0dbc14458adad81c0f3c0b9ba
Publikováno v:
Journal of Fungi, Vol 8, Iss 1, p 69 (2022)
The fungal cytochrome P450 lanosterol 14α-demethylase (CYP51) is required for the biosynthesis of fungal-specific ergosterol and is the target of azole antifungal drugs. Despite proven success as a clinical target for azole antifungals, there is an
Externí odkaz:
https://doaj.org/article/8861ba2508d547b8953aff0aa4a211c1
Autor:
Danyon O. Graham, Rajni K. Wilson, Yasmeen N. Ruma, Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk
Publikováno v:
Journal of Fungi, Vol 7, Iss 11, p 897 (2021)
Target-based azole resistance in Candida albicans involves overexpression of the ERG11 gene encoding lanosterol 14α-demethylase (LDM), and/or the presence of single or multiple mutations in this enzyme. Overexpression of Candida albicans LDM (CaLDM)
Externí odkaz:
https://doaj.org/article/2fb14a794e4d4733aafc6a6df72d6c0b
Autor:
Rajni K. Wilson, Parham Hosseini, Mikhail V. Keniya, Brian C. Monk, Alia A. Sagatova, Yasmeen N. Ruma
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1868(3)
The cytochrome P450 enzyme lanosterol 14α-demethylase (LDM) is the target of the azole antifungals used widely in medicine and agriculture as prophylaxis or treatments of infections or diseases caused by fungal pathogens. These drugs and agrochemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1379bbc52616fd45c661bc381d85ea49
https://pubmed.ncbi.nlm.nih.gov/30851431
https://pubmed.ncbi.nlm.nih.gov/30851431
Publikováno v:
Antimicrobial agents and chemotherapy. 62(11)
Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are modest for immunocompromised patients and individuals with comorbidities. The effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7617e6b66f5d412d1654b2ff1d9aa00
https://pubmed.ncbi.nlm.nih.gov/30126959
https://pubmed.ncbi.nlm.nih.gov/30126959