Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Yasir Mohamud"'
Publikováno v:
Biology, Vol 13, Iss 6, p 431 (2024)
Mitochondria serve an ultimate purpose that seeks to balance the life and death of cells, a role that extends well beyond the tissue and organ systems to impact not only normal physiology but also the pathogenesis of diverse diseases. Theorized to ha
Externí odkaz:
https://doaj.org/article/42491b3ab1604f3a863538e9c0bc7edc
Autor:
Amirhossein Bahreyni, Huitao Liu, Yasir Mohamud, Yuan Chao Xue, Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Honglin Luo
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Immunotherapy has emerged as an efficient therapeutic approach for cancer management. However, stimulation of host immune system against cancer cells often fails to achieve promising clinical outcomes mainly owing to the immunosup
Externí odkaz:
https://doaj.org/article/d88330b287564f6d9acbca6f49224a99
Autor:
Huitao Liu, Amirhossein Bahreyni, Yasir Mohamud, Yuan Chao Xue, William W.G. Jia, Honglin Luo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 89-99 (2022)
Genetic modification of coxsackievirus B3 (CVB3) by inserting target sequences (TS) of tumor-suppressive and/or organ-selective microRNAs (miRs) into viral genome can efficiently eliminate viral pathogenesis without significant impacts on its oncolyt
Externí odkaz:
https://doaj.org/article/4a94222077354ffa8c7295b92634621a
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114789- (2023)
There is growing evidence showing that single administration of immunotherapeutic agents has limited efficacy in a number of cancer patients mainly due to tumor heterogeneity and immunosuppressive tumor microenvironment. In this study, a novel nanopa
Externí odkaz:
https://doaj.org/article/b9a6af62f98d4441a1f2af08813b8da3
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114243- (2023)
Melanoma is a malignant tumor that accounts for the deadliest form of skin cancers. Despite the significant efforts made recently for development of immunotherapeutic strategies including using immune checkpoint inhibitors and cancer vaccines, the cl
Externí odkaz:
https://doaj.org/article/0a7af27a5bd644629afdc7326f454c0f
Autor:
Yuan Chao Xue, Huitao Liu, Yasir Mohamud, Amirhossein Bahreyni, Jingchun Zhang, Neil R. Cashman, Honglin Luo
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neuron system associated with both genetic and environmental risk factors. Infection with enteroviruses, including poliovirus and coxsackievirus
Externí odkaz:
https://doaj.org/article/0c9b7a43ad164b81bf0ae6e022e49fb3
Publikováno v:
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Breast cancer continues to be the most frequently diagnosed malignancy among women, putting their life in jeopardy. Cancer immunotherapy is a novel approach with the ability to boost the host immune system to recognize and eradicate cancer c
Externí odkaz:
https://doaj.org/article/1bfc9c3b1619490082815b0d172b9248
Publikováno v:
Viruses, Vol 15, Iss 2, p 351 (2023)
The myocardium/heart is the most mitochondria-rich tissue in the human body with mitochondria comprising approximately 30% of total cardiomyocyte volume. As the resident “powerhouse” of cells, mitochondria help to fuel the high energy demands of
Externí odkaz:
https://doaj.org/article/79a534f58c354fd887527ef31d8e9223
Autor:
Huitao Liu, Yuan Chao Xue, Haoyu Deng, Yasir Mohamud, Chen Seng Ng, Axel Chu, Chinten James Lim, William W. Lockwood, William W.G. Jia, Honglin Luo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 207-218 (2020)
We recently discovered that coxsackievirus B3 (CVB3) is a potent oncolytic virus against KRAS mutant lung adenocarcinoma. Nevertheless, the evident toxicity restricts the use of wild-type (WT)-CVB3 for cancer therapy. The current study aims to engine
Externí odkaz:
https://doaj.org/article/f7045a01818a4c3ba9b89afc259e27a9
Autor:
Haoyu Deng, Huitao Liu, Tanya de Silva, YuanChao Xue, Yasir Mohamud, Chen Seng Ng, Junyan Qu, Jingchun Zhang, William W.G. Jia, William W. Lockwood, Honglin Luo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 14, Iss , Pp 266-278 (2019)
KRAS mutant (KRASmut) lung adenocarcinoma is a refractory cancer without available targeted therapy. The current study explored the possibility to develop coxsackievirus type B3 (CVB3) as an oncolytic agent for the treatment of KRASmut lung adenocarc
Externí odkaz:
https://doaj.org/article/17b2ce6a3cf94fcba0a5b51a621b6a91