Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yasir Alsiraj"'
Autor:
Yasir AlSiraj, Xuqi Chen, Sean E. Thatcher, Ryan E. Temel, Lei Cai, Eric Blalock, Wendy Katz, Heba M. Ali, Michael Petriello, Pan Deng, Andrew J. Morris, Xuping Wang, Aldons J. Lusis, Arthur P. Arnold, Karen Reue, Katherine Thompson, Patrick Tso, Lisa A. Cassis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Men and women differ in their risk of developing coronary artery disease, in part due to differences in their levels of sex hormones. Here, AlSiraj et al. show that the XX sex genotype regulates lipid metabolism and promotes atherosclerosis independe
Externí odkaz:
https://doaj.org/article/779e3daba0e549a3b1b7cf483d20172c
Autor:
Lucrecia Valdez, Yasir AlSiraj, Hong Huang, John A Bauer, Aurelia Radulescu, Dolph Davis, Robin C Shoemaker
Publikováno v:
Hypertension. 79
Background: The prevalence of hypertension in children and adolescents is rising, with 13% having elevated blood pressure and 5% having hypertension. Sex differences play a role in cardiovascular diseases in adults but are not well defined in youth.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd04edbb8d13d750f09a7c33ee9f13de
https://doi.org/10.1161/hyp.79.suppl_1.p092
https://doi.org/10.1161/hyp.79.suppl_1.p092
Autor:
Lucrecia K Valdez, Hong Huang, Yasir AlSiraj, Margaret Murphy, Micaila R Oberle, Dolph L Davis III, John A Bauer, Aurelia Radulescu, Robin Shoemaker
Publikováno v:
Journal of Hypertension. 41:e469
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5c5e0c21cf9b2b5ef6ba651998f6d7
https://doi.org/10.1097/01.hjh.0000917688.57859.d7
https://doi.org/10.1097/01.hjh.0000917688.57859.d7
Autor:
E. Gordon, Yasir Alsiraj, Christopher M. Waters, Charles Mark Ensor, Suresh Keshavamurthy, Robin Shoemaker, Brittany E. Dong, Jamie Sturgill, Lisa A. Cassis
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Angiotensin converting enzyme 2 (ACE2) is an enzyme that limits activity of the renin-angiotensin system (RAS) and also serves as a receptor for the SARS-CoV-2 Spike (S) protein. Binding of S protein to ACE2 causes internalization which activates loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909d1417e78696507ff97493f75da180
https://doi.org/10.1101/2021.09.14.460275
https://doi.org/10.1101/2021.09.14.460275
Autor:
Christopher M. Waters, Mark Ensor, Jamie Sturgill, Robin Shoemaker, Lisa A. Cassis, Yasir Alsiraj
Publikováno v:
Hypertension. 78
Angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 receptor and an enzyme of the renin-angiotensin system (RAS), is on the X chromosome and stimulated by estrogen. Male sex is a risk factor for SARS-CoV-2 severity. Previous investigators demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64fe55b171fef9555f8c4b0543677de6
https://doi.org/10.1161/hyp.78.suppl_1.mp62
https://doi.org/10.1161/hyp.78.suppl_1.mp62
Autor:
Xuqi Chen, Patrick Tso, Ryan E. Temel, Sean E. Thatcher, Pan Deng, Michael C. Petriello, Xuping Wang, Wendy S. Katz, Yasir Alsiraj, Heba Ali, Eric M. Blalock, Lisa A. Cassis, Katherine L. Thompson, Aldons J. Lusis, Karen Reue, Andrew J. Morris, Arthur P. Arnold, Lei Cai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Men and women differ in circulating lipids and coronary artery disease (CAD). While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determined by sex hormones and chromosomes, but effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5729e03509f5e1093113dc228fda1605
http://link.springer.com/article/10.1038/s41467-019-10462-z
http://link.springer.com/article/10.1038/s41467-019-10462-z
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Combined neprilysin (NEP) inhibition (sacubitril) and angiotensin type 1 receptor (AT1R) antagonism (valsartan) is used in the treatment of congestive heart failure and is gaining interest for other angiotensin II (AngII)-related cardiovascular disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df8b78630afaaca563443c861737aea
https://pubmed.ncbi.nlm.nih.gov/34561274
https://pubmed.ncbi.nlm.nih.gov/34561274
Autor:
Wesley N. Saintilnord, Ying H. Shen, Arthur P. Arnold, Alan Daugherty, Yasir Alsiraj, Scott A. LeMaire, Eric M. Blalock, Lisa A. Cassis, Wei Luo, Sean E. Thatcher, Hong Lu
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Turner syndrome women (monosomy X) have high risk of aortopathies consistent with a role for sex chromosomes in disease development. We demonstrated that sex chromosomes influence regional development of Ang II (angiotensin II)–induced a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5833923952725bb154d1f20c3cdb186f
https://doi.org/10.1161/atvbaha.120.314407
https://doi.org/10.1161/atvbaha.120.314407
Autor:
Lisa A. Cassis, Alan Daugherty, Yasir Alsiraj, Eric M. Blalock, Bradley S. Fleenor, Sean E. Thatcher
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:143-153
Objective— Aortic pathologies exhibit sexual dimorphism, with aneurysms in both the thoracic and abdominal aorta (ie, abdominal aortic aneurysm [AAA]) exhibiting higher male prevalence. Women have lower prevalence of aneurysms, but when they occur,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73f4d3beeec05a108b4666958c2adf6
https://doi.org/10.1161/atvbaha.117.310035
https://doi.org/10.1161/atvbaha.117.310035
Autor:
Sean E. Thatcher, Lisa A. Cassis, Kuey Chen, Richard Charnigo, Eric M. Blalock, Alan Daugherty, Yasir Alsiraj
Publikováno v:
Circulation. 135:379-391
Background: Abdominal aortic aneurysms (AAAs) are a deadly pathology with strong sexual dimorphism. Similar to humans, female mice exhibit far lower incidences of angiotensin II–induced AAAs than males. In addition to sex hormones, the X and Y sex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727ed3190c9a98b97a08479f89568954
https://doi.org/10.1161/circulationaha.116.023789
https://doi.org/10.1161/circulationaha.116.023789