Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Yashwant M. Deo"'
Autor:
William M. Mitchell, Yashwant M. Deo, Miroslaw K. Gorny, Constance Williams, Tibor Keler, Jerome L. Gabriel, Sherri Burda, Susan Zolla-Pazner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51ea08f871221ba08eb69241d2226dfd
https://doi.org/10.1159/000425174
https://doi.org/10.1159/000425174
Autor:
J. R. Kalden, Gerard Groenewegen, Geert H. Blijham, G Wieland, Yashwant M. Deo, Roland Repp, H.H van Ojik, Helmuth Steininger, Bernhard Stockmeyer, W Becker, Michael Eisenhut, Martin Gramatzki, C Oetzel, J.G.J. van de Winkel, T. Valerius
Publikováno v:
British Journal of Cancer
A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was performed in stage IV breast carcinoma patients, overexpressing HER-2/neu. MDX-H210, constructed by crosslinking antigen binding
Autor:
Christof Schweizer, Gudrun Strauss, Matthias Lindner, Alexander Marmé, Gerhard Moldenhauer, Yashwant M. Deo
Publikováno v:
Cancer Immunology, Immunotherapy. 51:621-629
Bispecific antibodies (bsAb) have attracted much attention over the past several years as a mean to improve immunotherapy of cancer. Due to their dual specificity, bsAb are able to redirect effector cells against tumor targets. In this study, the dev
Autor:
Yashwant M. Deo, Robert F. Graziano, Christina Russoniello, Karuna Sundarapandiyan, Tibor Keler, Paul K. Wallace, Laura Vitale
Publikováno v:
The Journal of Immunology. 164:5746-5752
Macrophages represent an important effector cell for Ab-mediated tumor therapy. Previous studies have documented that cytokines can influence Fc receptor (FcR) expression and function. In this study we examined the tumoricidal activities of the type
Publikováno v:
Blood. 94:2112-2120
Cross-linking of Fc receptors for IgA, FcR (CD89), on monocytes/macrophages is known to enhance phagocytic activity and generation of oxygen free radicals. We provide evidence here that the FcR signals through the γ subunit of FcɛRI in U937 c
Publikováno v:
Blood. 94:2112-2120
Cross-linking of Fc receptors for IgA, FcalphaR (CD89), on monocytes/macrophages is known to enhance phagocytic activity and generation of oxygen free radicals. We provide evidence here that the FcalphaR signals through the gamma subunit of Fcepsilon
Autor:
Yashwant M. Deo, Conway Gee, Susan Groshen, R. Curnow, Verna Marty, J. Link, V. Pullarkat, L. Spears, Jeffrey S. Weber
Publikováno v:
Cancer Immunology, Immunotherapy. 48:9-21
A phase I study of escalating doses of humanized bispecific antibody (bsAb) MDX-H210 with granulocyte-colony-stimulating factor (G-CSF) was conducted in patients with metastatic breast cancer that overexpressed HER2/neu. The main objectives of the st
Autor:
Yashwant M. Deo, Daniel F. Hayes, Paul K. Wallace, Michiaki Watanabe, Tibor Keler, Charuwan Akewanlop
Publikováno v:
Breast Cancer Research and Treatment. 53:199-207
Background: MDX-210 is a bispecific antibody (BsAb) with specificity for both the proto-oncogene product of HER-2/neu (c-erbB-2) and FcγRI (CD64). HER-2/neu is overexpressed in malignant tissue of approximately 30% of patients with breast cancer, an
Publikováno v:
The Journal of Immunology. 160:1677-1686
The FcR for IgA (FcαRI, CD89) is primarily expressed on cytotoxic immune effector cells. By chemically cross-linking F(ab′) fragments of the FcR for IgA (FcαRI)-specific mAb (A77) with tumor Ag-specific mAb (anti-HER2/neu and anti-epidermal growt
Autor:
Joachim R. Kalden, Thomas Valerius, Yashwant M. Deo, Martin Gramatzki, Annemiek B. van Spriel, Roland Repp, Bernhard Stockmeyer, Robert Graziano, John E. Lund, Jan G. J. van de Winkel, Ingrid E. van den Herik-Oudijk
Publikováno v:
Blood. 90:4485-4492
Promising results from clinical trials with unconjugated antibodies stimulated renewed interest in immune effector mechanisms of monoclonal antibodies (MoAbs). We investigated the potential of IgA as antibody isotype for cell- or complement-mediated