Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yashna, Paul"'
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Autor:
Manasi Ratnaparkhe, John K. L. Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T. W. Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M. Downing, Stefan M. Pfister, Marc Zapatka, Peter J. McKinnon, Frederick W. Alt, Peter Lichter, Aurélie Ernst
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chromothripsis and chromoanasynthesis lead to locally clustered rearrangements affecting one or a few chromosomes, but their impact on cancer development and progression is unclear. Here the authors analyse the role of DNA repair factors in brain tum
Externí odkaz:
https://doaj.org/article/8c14a72fa08b47349febd37357e6a636
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-18 (2017)
Abstract Background Glioma is the most common of all primary brain tumors with poor prognosis and high mortality. The 2016 World Health Organization classification of the tumors of central nervous system uses molecular parameters in addition to histo
Externí odkaz:
https://doaj.org/article/3b1651e12c2e4c55998b26715fe3b806
Autor:
Sascha Dietrich, Irene Gil-Farina, Selcen Öztürk, Marc Zapatka, Peter Lichter, Lavinia Arseni, Manfred Schmidt, Bola S. Hanna, Philipp M. Roessner, Anna Jauch, Stephan Stilgenbauer, Peter-Martin Bruch, Saira Afzal, Yashna Paul, Martina Seiffert, Verena Kalter
Publikováno v:
Leukemia
Chronic lymphocytic leukemia (CLL) is a B-cell malignancy mainly occurring at an advanced age with no single major genetic driver. Transgenic expression of TCL1 in B cells leads after a long latency to a CLL-like disease in aged Eµ-TCL1 mice suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be562e2e6a735f38acc00cd848da34c2
http://europepmc.org/articles/PMC8807396
http://europepmc.org/articles/PMC8807396
Autor:
Laura Llaó Cid, John KL Wong, Marina Wierz, Yashna Paul, Tobias Roider, Iria Fernandez Botana, Susanne Gonder, Alessia Floerchinger, Dolors Colomer, Elías Campo, Sascha Dietrich, Peter Lichter, Marc Zapatka, Etienne Moussay, Jérôme Paggetti, Martina Seiffert
Publikováno v:
Blood. 140:1805-1806
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc245afd0b765e1c061c9835637c3ff1
https://doi.org/10.1182/blood-2022-167183
https://doi.org/10.1182/blood-2022-167183
Autor:
Yashna Paul, Yasha Hasija
Publikováno v:
Scientifica, Vol 2016 (2016)
Neurological disorders are known to show similar phenotypic manifestations like anxiety, depression, and cognitive impairment. There is a need to identify shared genetic markers and molecular pathways in these diseases, which lead to such comorbid co
Externí odkaz:
https://doaj.org/article/65cbf366489f4b2780d236fc8476c881
Autor:
Bola S, Hanna, Laura, Llaó-Cid, Murat, Iskar, Philipp M, Roessner, Lara C, Klett, John K L, Wong, Yashna, Paul, Nikolaos, Ioannou, Selcen, Öztürk, Norman, Mack, Verena, Kalter, Dolors, Colomer, Elías, Campo, Johannes, Bloehdorn, Stephan, Stilgenbauer, Sascha, Dietrich, Manfred, Schmidt, Richard, Gabriel, Karsten, Rippe, Markus, Feuerer, Alan G, Ramsay, Peter, Lichter, Marc, Zapatka, Martina, Seiffert
Publikováno v:
Immunity. 54(12)
T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses identified a subset o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7d083f208fa077095390dc49708bdbd
https://pubmed.ncbi.nlm.nih.gov/34879221
https://pubmed.ncbi.nlm.nih.gov/34879221
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-18 (2017)
Clinical Epigenetics
Clinical Epigenetics
Background Glioma is the most common of all primary brain tumors with poor prognosis and high mortality. The 2016 World Health Organization classification of the tumors of central nervous system uses molecular parameters in addition to histology to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28520fe81b396e08b14f44889184a38c
http://link.springer.com/article/10.1186/s13148-017-0331-9
http://link.springer.com/article/10.1186/s13148-017-0331-9
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Autor:
Agata Pastorczak, Wojciech Mlynarski, Aurélie Ernst, John Wong, Marc Zapatka, Milena Simovic, Paul A. Northcott, Anna Jauch, Frederick W. Alt, Stefan M. Pfister, Pei-Chi Wei, Daniel Haag, Manasi Ratnaparkhe, Mario Hlevnjak, David T. Jones, Andrey Korshunov, Thorsten Kolb, Marcel Kool, Frauke Devens, Yashna Paul, Rajesh Kumar, Peter Lichter, Susanna M. Downing, Peter J. McKinnon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic rearrangements (n = 16/26) in brain tumors developing in mice deficient for factors i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db436cc4fad7d53461bf7761f836338
https://doi.org/10.1038/s41467-018-06925-4
https://doi.org/10.1038/s41467-018-06925-4
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Autor:
Pei-Chi Wei, Frederick W. Alt, Marc Zapatka, Rajesh Kumar, Wojciech Mlynarski, Aurélie Ernst, Frauke Devens, Andrey Korshunov, Peter J. McKinnon, Stefan M. Pfister, Manasi Ratnaparkhe, David T. Jones, Mario Hlevnjak, John Wong, Daniel Haag, Marcel Kool, Paul A. Northcott, Thorsten Kolb, Yashna Paul, Peter Lichter, Agata Pastorczak, Susanna M. Downing, Anna Jauch
Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered genomic rearrangements. Whole-genome sequencing revealed frequent chromothripsis or chromoanasynthesis (n= 16/26) in brain tumors developing in mice deficient for fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae87bc19f734e20701af5a9641515c25
https://doi.org/10.1101/314518
https://doi.org/10.1101/314518
Autor:
Vikas Patil, Baisakhi Mondal, Sannu Thomas, Arimappamagan Arivazhagan, Yashna Paul, Kumaravel Somasundaram, Naveen Kumar, Vani Santosh, Alangar S. Hegde, Kulandaivelu Mahalingam
Publikováno v:
Oncotarget
The major part of the genome that was previously called junk DNA has been shown to be dynamically transcribed to produce non-coding RNAs. Among them, the long non-coding RNAs (lncRNA) play diverse roles in the cellular context and are therefore invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1364c76280198059c3738e10e01b96
https://pubmed.ncbi.nlm.nih.gov/30038703
https://pubmed.ncbi.nlm.nih.gov/30038703