Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yashar Sadian"'
Autor:
Christian Tüting, Fotis L. Kyrilis, Johannes Müller, Marija Sorokina, Ioannis Skalidis, Farzad Hamdi, Yashar Sadian, Panagiotis L. Kastritis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
How is acetyl-CoA produced in the context of the endogenous, eukaryotic pyruvate dehydrogenase complex metabolon? Here the authors dissect the embedded transacetylase reaction through biochemical, cryo-EM, HADDOCKing and molecular dynamics methods.
Externí odkaz:
https://doaj.org/article/146e4ee18ab64e4d98dd27f853aa29f7
Autor:
Olivier Mercey, Corinne Kostic, Eloïse Bertiaux, Alexia Giroud, Yashar Sadian, David C A Gaboriau, Ciaran G Morrison, Ning Chang, Yvan Arsenijevic, Paul Guichard, Virginie Hamel
Publikováno v:
PLoS Biology, Vol 20, Iss 6, p e3001649 (2022)
Inherited retinal degeneration due to loss of photoreceptor cells is a leading cause of human blindness. These cells possess a photosensitive outer segment linked to the cell body through the connecting cilium (CC). While structural defects of the CC
Externí odkaz:
https://doaj.org/article/324b3bd946084b33b93c62af5b632046
Autor:
Kaushik Bhattacharya, Lorenz Weidenauer, Tania Morán Luengo, Ellis C. Pieters, Pablo C. Echeverría, Lilia Bernasconi, Diana Wider, Yashar Sadian, Margreet B. Koopman, Matthieu Villemin, Christoph Bauer, Stefan G. D. Rüdiger, Manfredo Quadroni, Didier Picard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Hop, also known as Stip1 or Sti1, facilitates substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Characterization of proteostasis-related pathways in STIP1 knock-out cell lines reveals that in eukaryotes Stip1 modulates the balance
Externí odkaz:
https://doaj.org/article/82875625c72b4d9c8c7eaaf0131c13bc
Autor:
Yashar Sadian, Florence Baudin, Lucas Tafur, Brice Murciano, Rene Wetzel, Felix Weis, Christoph W. Müller
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
RNA polymerase I (Pol I) catalyses the transcription of pre-ribosomal RNA and for transcription initiation Pol I assembles with core factor and Rrn3 on the rDNA core promoter. Here the authors provide insights into the molecular mechanism of promoter
Externí odkaz:
https://doaj.org/article/2f9e5295c8a243efb432a2a00bad71af
Publikováno v:
eLife, Vol 8 (2019)
RNA polymerase (Pol) I is a 14-subunit enzyme that solely transcribes pre-ribosomal RNA. Cryo-electron microscopy (EM) structures of Pol I initiation and elongation complexes have given first insights into the molecular mechanisms of Pol I transcript
Externí odkaz:
https://doaj.org/article/244403cef01148f9b74c97d0c9727d3c
Autor:
Yashar Sadian, Christos Gatsogiannis, Csilla Patasi, Oliver Hofnagel, Roger S Goody, Marian Farkašovský, Stefan Raunser
Publikováno v:
eLife, Vol 2 (2013)
Septins are guanine nucleotide-binding proteins that polymerize into filamentous and higher-order structures. Cdc42 and its effector Gic1 are involved in septin recruitment, ring formation and dissociation. The regulatory mechanisms behind these proc
Externí odkaz:
https://doaj.org/article/31f86628700d41358b2f7532a4f9189d
Autor:
Manoël Prouteau, Clélia Bourgoint, Jan Felix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas N. Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
Publikováno v:
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Target of rapamycin complex 1 (TORC1) is a protein kinase controlling cell homeostasis and growth in response to nutrients and stresses. In Saccharomyces cerevisiae, glucose depletion triggers a redistribution of TORC1 from a dispersed localization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de385eae15c75ba00807566c3ccd26b
https://hdl.handle.net/1854/LU-01GTKZAA283Q7VP03D5AKPZYWP
https://hdl.handle.net/1854/LU-01GTKZAA283Q7VP03D5AKPZYWP
Autor:
Dmitry A. Semchonok, Marina I. Siponen, Christian Tüting, Quentin Charras, Fotis L. Kyrilis, Farzad Hamdi, Yashar Sadian, Colette Jungas, Panagiotis L. Kastritis
The reaction centre-light harvesting 1 (RC-LH1) complex is essential for converting light into proton motive force in photosynthetic bacteria. RC-LH1 is a monomer in most purple bacteria, but in Rhodobacter species, it is a dimer. Its assembly depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::759e6b9eaf9f5a74b3c71e0ec6268408
https://doi.org/10.1101/2022.02.25.481955
https://doi.org/10.1101/2022.02.25.481955
Autor:
Brice Murciano, Lucas Tafur, Yashar Sadian, Christoph W. Müller, Florence Baudin, Felix Weis, Rene Wetzel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
RNA polymerase I (Pol I) assembles with core factor (CF) and Rrn3 on the rDNA core promoter for transcription initiation. Here, we report cryo-EM structures of closed, intermediate and open Pol I initiation complexes from 2.7 to 3.7 Å resolution to
Autor:
Yashar Sadian, Tobias Raisch, David Barford, Pramod M Sabale, Chloe M. Ghent, Pierre Raia, Simone Cavadini, Andreas Boland, Jun Yu, David O. Morgan, Stefan Raunser
Publikováno v:
Nature
In early mitosis, the duplicated chromosomes are held together by the ring-shaped cohesin complex1. Separation of chromosomes during anaphase is triggered by separase—a large cysteine endopeptidase that cleaves the cohesin subunit SCC1 (also known