Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Yash A. Choksi"'
Autor:
Jia Li, Alan J. Simmons, Caroline V. Hawkins, Sophie Chiron, Marisol A. Ramirez-Solano, Naila Tasneem, Harsimran Kaur, Yanwen Xu, Frank Revetta, Paige N. Vega, Shunxing Bao, Can Cui, Regina N. Tyree, Larry W. Raber, Anna N. Conner, Jennifer M. Pilat, Justin Jacobse, Kara M. McNamara, Margaret M. Allaman, Gabriella A. Raffa, Alain P. Gobert, Mohammad Asim, Jeremy A. Goettel, Yash A. Choksi, Dawn B. Beaulieu, Robin L. Dalal, Sara N. Horst, Baldeep S. Pabla, Yuankai Huo, Bennett A. Landman, Joseph T. Roland, Elizabeth A. Scoville, David A. Schwartz, M. Kay Washington, Yu Shyr, Keith T. Wilson, Lori A. Coburn, Ken S. Lau, Qi Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Crohn’s disease (CD) is a complex chronic inflammatory disorder with both gastrointestinal and extra-intestinal manifestations associated immune dysregulation. Analyzing 202,359 cells from 170 specimens across 83 patients, we identify a di
Externí odkaz:
https://doaj.org/article/0ba81d63e38741479e8c66302f19cf18
Autor:
Kasey M. Schalich, Matthew A. Buendia, Harpreet Kaur, Yash A. Choksi, M. Kay Washington, Gabriela S. Codreanu, Stacy D. Sherrod, John A. McLean, Richard M. Peek, Jr., Sari A. Acra, Steven D. Townsend, Fang Yan
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTObservational evidence suggests that human milk oligosaccharides (HMOs) promote the growth of commensal bacteria in early life and adulthood. However, the mechanisms by which HMOs benefit health through modulation of gut microbial homeostasis
Externí odkaz:
https://doaj.org/article/b1067dced790480e8612a3e92377e026
Autor:
Justin Jacobse, Jennifer M. Pilat, Jing Li, Rachel E. Brown, Aaron Kwag, Matthew A. Buendia, Yash A. Choksi, M. Kay Washington, Christopher S. Williams, Nicholas O. Markham, Sarah P. Short, Jeremy A. Goettel
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
IntroductionThe pro-inflammatory cytokine interleukin-23 (IL-23) has been implicated in colorectal cancer (CRC). Yet, the cell-specific contributions of IL-23 receptor (IL-23R) signaling in CRC remain unknown. One of the cell types that highly expres
Externí odkaz:
https://doaj.org/article/6947d7d90a02414ea9d2f0a99aacdfe4
Autor:
Justin Jacobse, Zaryab Aziz, Lili Sun, Jasmine Chaparro, Jennifer M. Pilat, Aaron Kwag, Matthew Buendia, Mae Wimbiscus, Motomi Nasu, Tsuyoshi Saito, Shinji Mine, Hajime Orita, Frank Revetta, Sarah P. Short, M. Kay Washington, Girish Hiremath, Michael K. Gibson, Lori A. Coburn, Tatsuki Koyama, Jeremy A. Goettel, Christopher S. Williams, Yash A. Choksi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 6, Pp 961-983 (2023)
Background and Aims: Eosinophils are present in several solid tumors and have context-dependent function. Our aim is to define the contribution of eosinophils in esophageal squamous cell carcinoma (ESCC), as their role in ESCC is unknown. Methods: Eo
Externí odkaz:
https://doaj.org/article/535c54c9fb8d4824bb0c1da6e4ad6d4b
Autor:
Jennifer M. Pilat, Rachel E. Brown, Zhengyi Chen, Nathaniel J. Berle, Adrian P. Othon, M. Kay Washington, Shruti A. Anant, Suguru Kurokawa, Victoria H. Ng, Joshua J. Thompson, Justin Jacobse, Jeremy A. Goettel, Ethan Lee, Yash A. Choksi, Ken S. Lau, Sarah P. Short, Christopher S. Williams
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Although selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to sporadic CRC. In human singl
Externí odkaz:
https://doaj.org/article/f37c3c97bdc44595a82e0f79ef398d19
Autor:
Justin Jacobse, Rachel E. Brown, Jing Li, Jennifer M. Pilat, Ly Pham, Sarah P. Short, Christopher T. Peek, Andrea Rolong, M. Kay Washington, Ruben Martinez-Barricarte, Mariana X. Byndloss, Catherine Shelton, Janet G. Markle, Yvonne L. Latour, Margaret M. Allaman, James E. Cassat, Keith T. Wilson, Yash A. Choksi, Christopher S. Williams, Ken S. Lau, Charles R. Flynn, Jean-Laurent Casanova, Edmond H.H.M. Rings, Janneke N. Samsom, Jeremy A. Goettel
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112128- (2023)
Summary: The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched in intestinal Tregs, yet whether IL-23 modulates intestinal Tregs rem
Externí odkaz:
https://doaj.org/article/26b1ca6a3bad4a7d8ad24a3662d8812c
Autor:
Rachel E. Brown, Justin Jacobse, Shruti A. Anant, Koral M. Blunt, Bob Chen, Paige N. Vega, Chase T. Jones, Jennifer M. Pilat, Frank Revetta, Aidan H. Gorby, Kristy R. Stengel, Yash A. Choksi, Kimmo Palin, M. Blanca Piazuelo, Mary Kay Washington, Ken S. Lau, Jeremy A. Goettel, Scott W. Hiebert, Sarah P. Short, Christopher S. Williams
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Myeloid translocation gene 16 (MTG16, also known as CBFA2T3) is a transcriptional co
Externí odkaz:
https://doaj.org/article/5d314fb9ae044fb497de866e2b6326f8
Autor:
Eric E. Low, Qingyuan Song, Rena Yadlapati, Evan S. Dellon, Seema Aceves, Lin Liu, Samir Gupta, Yash A. Choksi, Shailja C. Shah
Publikováno v:
Clinical Gastroenterology and Hepatology.
Autor:
Keeli B. Lewis, Anna L. Means, Jalal A Hamaamen, Jinghuan Zi, Yash A. Choksi, David N. Hanna, Izumi Kaji, Connie J. Weaver, Qi Liu, Jing Yang, Paula Marincola Smith, Nicholas O. Markham, R. Daniel Beauchamp
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Supplemental Table 1. Five mice lacking intestinal SMAD4 expression ("KO") and five littermate control mice ("WT") had their colon microbiome composition compared. 16S targeted sequencing was performed on mouse stool pellets ("Pellet") and colon muco
Autor:
James C. Slaughter, Dawn B. Beaulieu, Miles Basil, Michael F. Vaezi, Tina Higginbotham, Sara N. Horst, Dawn W. Adams, Elizabeth A. Scoville, Robin Dalal, Yash A. Choksi, David A. Schwartz
Publikováno v:
Digestive Diseases and Sciences. 67:639-645
While the pathogenesis of inflammatory bowel disease (IBD) is incompletely understood, disruption of epithelial integrity is suspected to play a prominent role in disease initiation and progression. Currently, there is no convenient way to measure th