N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions

Autor: Bahadir Ceylan, Mehmet Ozansoy, Ülkan Kılıç, Yasemin Yozgat, Çilem Ercan, Pelin Yıldız, Turan Aslan

Publikováno v: Renal Failure, Vol 40, Iss 1, Pp 423-434 (2018)

Objective: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity. Methods: Twenty-eight Wistar rats were divided into four groups comprised o

Externí odkaz: https://doaj.org/article/5d0524963db041cab1fb2691312a486f

CYTOTOXIC EFFECTS OF ARCTIUM MINUS METHANOL EXTRACT ON VARIOUS CANCER CELL LINES

Autor: Ayşe Arzu ŞAKUL, Yasemin YOZGAT BYRNE, Ayşe Esra KARADAĞ, Ebrar ALTINALAN, Şeyma ÇİMEN, Mehmet Evren OKUR

Publikováno v: Volume: 46, Issue: 3 742-754
Journal of Faculty of Pharmacy of Ankara University
Ankara Üniversitesi Eczacılık Fakültesi Dergisi
Zeitschrift der Fakultät für Pharmazie der Universität Ankara
Revista de la Facultad de Farmacia de la Universidad de Ankara
Journal de la Faculté de Pharmacie de l'Université d'Ankara

Objective: This study aimed to evaluate the cytotoxic effects of Arctium minus (Hill) Bernh. ssp. minus methanol extract derived from aerial parts on cancer cell lines.Material and Method: For cytotoxicity assays, two different human breast cancer ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e837f0d7c6b2f3e0c95fbe2de17da02d
https://doi.org/10.33483/jfpau.1084639

Mediator-RNA Polymerase II Interactions Critical for Transcriptional Activation Are Mediated by the N-terminal Half of MED14 and C-terminal Domain of RPB1

Autor: Yasemin Baris, Javaid Jabbar, Yasemin Yozgat, Ege Cigirgan, Sadik Bay, Merve Erden Tucer, Volkan Aslan, Melike Dinccelik-Aslan, Murat Alper Cevher

Mediator is a large and evolutionarily conserved coactivator complex essential for RNA polymerase II (Pol II)-mediated gene regulation at multiple steps of the transcription process, including preinitiation complex (PIC) assembly and function. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7f2d2b9da402c788aa0819ef18505ea
https://doi.org/10.1101/2022.04.27.489650

N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions

Autor: Yasemin Yozgat, Cilem Ercan, Mehmet Ozansoy, Ulkan Kilic, Turan Aslan, Bahadir Ceylan, Pelin Yildiz

Publikováno v: Renal Failure
Renal Failure, Vol 40, Iss 1, Pp 423-434 (2018)

WOS: 000439906200002 PubMed ID: 30035652 Objective: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity.Methods: Twenty-eight Wistar rats w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bab1f4ac84ef7794286036cc78e689
https://hdl.handle.net/20.500.12645/37587

KIT Receptor Gain-of-Function in Hematopoiesis Enhances Stem Cell Self-Renewal and Promotes Progenitor Cell Expansion

Autor: Malcolm A.S. Moore, Shayu Deshpande, Christopher Y. Park, Benedikt Bosbach, Peter Besmer, Yasemin Yozgat

Publikováno v: Stem Cells. 31:1683-1695

The KIT receptor tyrosine kinase has important roles in hematopoiesis. We have recently produced a mouse model for imatinib resistant gastrointestinal stromal tumor (GIST) carrying the KitV558Δ and KitT669I (human KITT670I) mutations found in imatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c728c0eafac380844c3e7c4c8a3bb7
https://doi.org/10.1002/stem.1419