Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma

Autor: Johanna Wohlgensinger, Eva Maria Tinner, Eckard Hamelmann, Susanne Loeliger, Yasemin Darcan-Nicolaisen, Christina Weber-Chrysochoou, Remo Frei, Roger Lauener

Publikováno v: Weber-Chrysochoou, Christina; Darcan-Nicolaisen, Yasemin; Wohlgensinger, Johanna; Tinner, Eva Maria; Frei, Remo; Loeliger, Susanne; Lauener, Roger P; Hamelmann, Eckard (2021). Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma. International archives of allergy and immunology, 182(7), pp. 563-570. Karger 10.1159/000513296
Int Arch Allergy Immunol

Introduction: Environmental exposure to mites and fungi has been proposed to critically contribute to the development of IgE-mediated asthma. A common denominator of such organisms is chitin. Human chitinases have been reported to be upregulated by i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccbcee6d5a60c966e6771f9cf02ec26
https://doi.org/10.1159/000513296

Small Interfering RNA against Transcription Factor STAT6 Inhibits Allergic Airway Inflammation and Hyperreactivity in Mice

Autor: Eckard Hamelmann, Holger Meinicke, Yasemin Darcan-Nicolaisen, Gabriele Fels, Martin Witzenrath, Annekathrin Haberland, Christoph Loddenkemper, Olga Hegend, Anja A. Kühl, Wolfgang Henke, S. M. Kube

Publikováno v: The Journal of Immunology. 182:7501-7508

In the context of allergic immune responses, activation of STAT6 is pivotal for Th2-mediated IgE production and development of airway inflammation and hyperreactivity. We analyzed whether gene silencing of STAT6 expression by RNA interference was abl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f077443c26e9f41962cf30e0737c02
https://doi.org/10.4049/jimmunol.0713433

Primary Prevention of Allergic Diseases: Current Concepts and Mechanisms

Autor: Yasemin Darcan, Eckard Hamelmann, Kerstin Gerhold

Publikováno v: Allergy, Asthma & Clinical Immunology, Vol 3, Iss 4, Pp 105-113 (2007)
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology

Atopic diseases, the new "epidemic of the twenty-first century" and a central health problem of industrial nations, call for the development of innovative primary prevention strategies. The present review provides an overview of current experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231cb11411c98364367df92738742b0d
http://www.aacijournal.com/content/3/4/105

17. Mainzer Allergie-Workshop

Autor: Thomas Werfel, A. Cistero-Bahima, Alexander Gerbaulet, Sabine Ohlemacher, Bernadette Eberlein-König, Detlef Zillikens, Sonja Bailey, Mette Ribel, S. Soost, A. Güttsches, Hansjörg Schild, K. Heeg, Wolf-Georg Forssmann, Gabriele Weimer, C. Freising, R. Ludwig, Helmut Jonuleit, Stefanie Sommer, Yasemin Darcan, Robert Sabat, Jürgen Knop, Armin Braun, Ulf Forssmann, Tilo Biedermann, K. Ghoreschi, M. O’Keeffe, Shelley J Allen, Thilo Jakob, Stephan Sudowe, S. Ewig, Christian Kutzleb, Delphine C. Malherbe, G. Roider, Claudia Traidl-Hoffmann, Dave Dawbarn, Mar San-Miguel Moncin, Christoph Hüls, G. Burow, A.-K. Illner, M. Wittmann, Edgar Serfling, C. Bilitewski, Henning Weigt, M. Huhn, J. Kressel, D. Ernst, Kenny Pollock, Jürgen Grabbe, Stefanie Foerster, S. Glaser, T. Brüning, Franziska Ruëff, Â. Gaspar, Claudia Borelli, Carolyn Bauer, G. Pires, Eva Huter, M. Neumaier, Norbert Krug, Hanspeter Mart, Joachim Saloga, Valeska Heib, Eva Zahradnik, Jörg Kleine-Tebbe, Uta Jappe, S. Mkhlof, A. Conti, Lilla Landeck, Comelia Blume, S. Barth, S. Bade, Veit J. Erpenbeck, V. van Kampen, Eva Zindler, D. Wicklein, Arnd Petersen, Alexander Enk, Ulrike Seitzer, Tibor Veres, P. Rozynek, Stephan Baldus, Stefanie Förster, I. Dorn, Tobias Bopp, M. Meurer, Jan Kubach, U. Herz, Dagmar Simon, Helmut Renz, Franz-Josef Schneider, S. Werner, F. Haamann, M. Stöcker, Thomas Herzinger, M. Vetter, Torsten Zuberbier, Angelika B. Reske-Kunz, Günther Lametschwandtner, Guido Heine, M. Klotz, U. Zähringer, B. Backhaus, B. Summer, A. Boldt, W. Weber, Samuel B. Lehrer, Alex Straumann, Pius Heer, Stefan Vieths, Frank Siebenhaar, Peter Thomas, Tilmann Oppel, Eva Scharrer, Bernhard Przybilla, Torsten Schäfer, Shipra Gupta, Esra Tas, Lasse R. Braathen, K. Simon, Sebastian Straube, Karin Hartmann, T. Klockenbring, Andreas Wollenberg, Hae-Hyuk Lee, C. Hartz, G. Rohde, M. Schmelz, Milena Milovanovic, Margitta Worm, H. Hochrein, Jo Rae Wright, Ingrid Sander, W. A. Nockher, Christoph Schwärzler, K. Reinitz-Rademacher, Christina Nassenstein, Monika Raulf-Heimsoth, Albrecht Bufe, M. Schindewolf, S. Sel, C. Rundfeldt, Edgar Schmitt, Ingo Böttcher, Olga Weikum, Christoph Richter, Jan Gutermuth, P. Ahmad-Nejad, Iris Bellinghausen, Christian Müller, Tanja Stünkel, I. Weichenmeier, Katharina Albert, F. Alessandrini, S. Maier, Matthias Klein, Christina Hartmann, P. Rieber, P C Konturek, Rolf Merget, F. Eberhardt, Claudia Günther, Petra Weingarten, C. Hahn, K. Breuer, Evelyn Montermann, U.-C. Hipler, S. Schmelz, Wolf-Meinhard Becker, Julia Viebranz, B. Belloni, A. Nabe, Martin Raithel, R. Kaufmann, Jeroen Buters, S. Abraham, Hans-Peter Rihs, Claudia M. Trujillo-Vargas, Christian Becker, Rahul Purwar, D. Hartwig, Jens M. Hohlfeld, Jürgen Galle, Jörn Elsner, S. Klaus, Stephan Scheurer, S. Lubitz, Oliver Drews, Eckhart G. Hahn, Klaus J. Erb, E. P. Rieber, Wolfgang Schober, C. Betzel, S. Mrabet-Dahbi, Bernhard F. Gibbs, S. Wildner, W. H. Boehncke, A. Ebling, B. Schuhmann, Ralf Bälder, Bettina König, Stefanie Randow, Sandra Schulz-Maronde, Ulf Darsow, Martin Blüggel, M. M. San Miguel-Moncin, Martina Thiel, S. Kespohl, Andreas J. Bircher, Ursula Krämer, Petra Lutter, E. Lindhoff-Last, M. Wegmann, Michael Stassen, Heidrun Behrendt, Aleksandra Heitland, Hans-Uwe Simon, Franziska Ruäff, A. Kasche, K. Gehlhar, Liane M. Preussner, Kilian Eyerich, Jabbar Ahmed, Johannes Huss-Marp, Katja Langer, Stefan Klein-Heßling, Peter Elsner, Alexander Kapp, M. Hoffmann, Michael Weidenhiller, Markus Magerl, Steffen Schmitt, B. Schlatter, Knut Schäkel, Dietmar A. Herold, Barbara Fuchs, C. Fleischer, Marcus Maurer, S.E. Escher, Gerald Reese, Andrea Bauer, S. Löseke, E.-M. Fiedler, Antal Rot, H.-H. Gorris, Angelika Görg, José M. Carballido, Alois Palmetshofer, Knut Brockow, M. Braun-Falco, Iris Lauer, Johannes Ring, Karl Sotlar, Tina Ristau, K. Hirsch, S. Riecken, R. Draheim, A. Pirayesh, M. Heitmann, Kirsten Tangemann

Publikováno v: Allergo Journal. 14:30-47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08d81aafb53f887ada4cf01a1f758c7c
https://doi.org/10.1007/bf03370389

Cis-9,trans-11-conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARgamma-related mechanism in mice

Autor: Anke, Jaudszus, Martin, Krokowski, Peter, Möckel, Yasemin, Darcan, Anzhela, Avagyan, Paolo, Matricardi, Gerhard, Jahreis, Eckard, Hamelmann

Publikováno v: The Journal of nutrition. 138(7)

Milk consumption from early childhood on has been found to be inversely correlated with allergic sensitization and the onset of bronchial asthma. We tested whether cis-9,trans-11-conjugated linoleic acid (c9,t11-CLA), naturally occurring in milk fat,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbad07f4d52236eccc98ecc809ba7c04
https://pubmed.ncbi.nlm.nih.gov/18567757