Výsledky vyhledávání - "Yasemin D. Yazici"

Growth-Inhibitory Effects of Human Anti-Insulin-Like Growth Factor-I Receptor Antibody (A12) in an Orthotopic Nude Mouse Model of Anaplastic Thyroid Carcinoma

Autor: Samar A. Jasser, Zhuoying Wang, Yasemin D. Yazici, Seungwon Kim, Geetika Chakravarty, Jeffrey N. Myers, Adel K. El-Naggar, Maher N. Younes, Corazon D. Bucana, Alfredo A. Santillan

Publikováno v: Clinical Cancer Research. 12:4755-4765

Purpose: The insulin-like growth factor-I receptor (IGF-IR) and its ligands have been implicated in the pathogenesis and progression of various cancers, including those arising in the thyroid gland. We therefore evaluated whether the IGF-IR could ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2545bfdcc9f2d1dcc78587c98f5b568d
https://doi.org/10.1158/1078-0432.ccr-05-2691

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Dual Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor Inhibition with NVP-AEE788 for the Treatment of Aggressive Follicular Thyroid Cancer

Autor: Seungwon Kim, Yasemin D. Yazici, Jeffrey N. Myers, Adel K. El-Naggar, Maher N. Younes, Samar A. Jasser

Publikováno v: Clinical Cancer Research. 12:3425-3434

Purpose: Patients with radioiodine-resistant follicular thyroid cancer (FTC) have a poor prognosis, if metastasized, with currently available treatment modalities. Epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) and their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8852a14d0715eea961122b0709bfd052
https://doi.org/10.1158/1078-0432.ccr-06-0793

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Antivascular Therapy of Oral Tongue Squamous Cell Carcinoma with PTK787

Autor: Samar A. Jasser, Seungwon Kim, Zhuoying Wang, Yasemin D. Yazici, Kenny B. Carter, Jeffrey N. Myers, Corazan D. Bucana

Publikováno v: The Laryngoscope. 115:2249-2255

Objectives/Hypothesis: Vascular endothelial growth factor (VEGF) is an important mediator in tumor vascularization, growth, and metastasis. We investigated whether blockade of the VEGF receptor (VEGF-R) signaling pathway by the tyrosine kinase inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b6ebf7183c009fabfaf9012690400b
https://doi.org/10.1097/01.mlg.0000183861.53765.77

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Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer

Autor: Mahitosh Mandal, Samar A. Jasser, Adel K. El-Naggar, Bradley A. Schiff, Gordon B. Mills, Benjamin N. Bekele, Yasemin D. Yazici, Jeffrey N. Myers, Orhan G. Yigitbasi, Maher N. Younes, Seungwon Kim

Publikováno v: Molecular Cancer Therapeutics. 4:1146-1156

We investigated integrin-linked kinase (ILK), a focal adhesion serine-threonine protein kinase, as a new molecular target for treating anaplastic thyroid cancer. ILK mediates cell growth and survival signals and is overexpressed in a number of cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191beca66ba5229c0dc6b80b1f989ede
https://doi.org/10.1158/1535-7163.mct-05-0078

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Antivascular Therapy of Human Follicular Thyroid Cancer Experimental Bone Metastasis by Blockade of Epidermal Growth Factor Receptor and Vascular Growth Factor Receptor Phosphorylation

Autor: Benjamin N. Bekele, Isaiah J. Fidler, Mahitosh Mandal, Yasemin D. Yazici, Samar A. Jasser, Sun Jin Kim, Valerie S. Hawthorne, Young Wook Park, Corazon D. Bucana, Maher N. Younes, Jeffrey N. Myers, Orhan G. Yigitbasi

Publikováno v: Cancer Research. 65:4716-4727

Patients suffering from bone metastases of follicular thyroid carcinoma (FTC) have a poor prognosis because of the lack of effective treatment strategies. The overexpression of epidermal growth factor receptor (EGFR) associated with increased vascula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45590f5701dd26d827d191505413f86f
https://doi.org/10.1158/0008-5472.can-04-4196

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Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice

Autor: Jeffrey N. Myers, Zhuo Ying Wang, Samar A. Jasser, Gabriel G. Calzada, Seungwon Kim, Maher N. Younes, Adel K. El-Naggar, Yasemin D. Yazici

Publikováno v: Molecular cancer therapeutics. 6(6)

Anaplastic thyroid carcinoma (ATC) remains one of the most lethal human cancers. We hypothesized that sorafenib, a multikinase inhibitor of the BRaf, vascular endothelial growth factor receptor-2, and platelet-derived growth factor receptor-β kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6deb4ccd96403980f2505ec0e879c2fe
https://pubmed.ncbi.nlm.nih.gov/17575107

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Structural basis for depletion of heat shock protein 90 client proteins by deguelin

Autor: Soon-Sun Hong, Woo-Young Kim, Seung Hyun Oh, Jong Kyu Woo, Ho-Young Lee, Suh Young-Ger, Hyun Ju Park, Quanri Jin, Kim Kyu Won, Yasemin D. Yazici, Waun Ki Hong, Jeffrey N. Myers

Publikováno v: Journal of the National Cancer Institute. 99(12)

BACKGROUND: The molecular chaperone heat shock protein 90 (Hsp90) participates in preserving the expression and activity of various oncoproteins, including hypoxia-inducible factor 1alpha (HIF-1alpha) and Akt. Deguelin is a rotenoid with antitumor ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c76b318299841df8bfa85810abc5573
https://pubmed.ncbi.nlm.nih.gov/17565155

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Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck

Autor: Cora Bucana, Samar A. Jasser, Maher N. Younes, Jeffrey N. Myers, Orhan G. Yigitbasi, Yasemin D. Yazici, Gordon B. Mills, Adel K. El-Naggar

Publikováno v: Archives of otolaryngology--headneck surgery. 133(1)

Objective To study the expression of integrin-linked kinase (ILK) in human squamous cell carcinoma of the head and neck (SCCHN) tumor specimens and cell lines and the efficacy of the novel small molecule QLT0267. Design Immunohistochemical analysis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e7c0382423bd9b836b75a88921f36b
https://pubmed.ncbi.nlm.nih.gov/17224516

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Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model

Autor: Jeffrey N. Myers, Adel K. El-Naggar, Alfredo A. Santillan, Seungwon Kim, Maher N. Younes, Samar A. Jasser, Young Wook Park, Yasemin D. Yazici, Meirong Gu, Xiaolin Nong

Publikováno v: Molecular cancer therapeutics. 5(11)

We hypothesized that epidermal growth factor (EGF) receptor (EGFR) activation and vascular endothelial growth factor (VEGF)–induced angiogenic signals are important for the progression and metastasis of human salivary adenoid cystic carcinoma (ACC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3595c14ecad3b412b1b5c2141041dbbe
https://pubmed.ncbi.nlm.nih.gov/17121916

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Cetuximab and irinotecan interact synergistically to inhibit the growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice

Autor: Maher N. Younes, Christopher N. Prichard, Samar A. Jasser, Seungwon Kim, B. Nebiyou Bekele, Jeffrey N. Myers, Yasemin D. Yazici

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 12(2)

Purpose: Anaplastic thyroid carcinoma (ATC) remains one of the most lethal known human cancers. Targeted molecular therapy with cetuximab, a monoclonal antibody against epidermal growth factor receptor, offers new treatment potentials for patient wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ae4bef02f8f02545a852c7ce8168da
https://pubmed.ncbi.nlm.nih.gov/16428506

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