Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy

Autor: Fejzo, M, Rocha, N, Cimino, I, Lockhart, SM, Petry, C, Kay, RG, Burling, K, Barker, P, George, AL, Yasara, N, Premawardhena, A, Gong, S, Cook, E, Rainbow, K, Withers, DJ, Cortessis, V, Mullin, PM, MacGibbon, KW, Jin, E, Kam, A, Campbell, A, Polasek, O, Tzoneva, G, Gribble, FM, Yeo, GSH, Lam, BYH, Saudek, V, Hughes, IA, Ong, KK, Perry, JRB, Sutton Cole, A, Baumgarten, M, Welsh, P, Sattar, N, Smith, GCS, Charnock Jones, DS, Coll, AP, Meek, CL, Mettananda, S, Hayward, C, Mancuso, N, O’Rahilly, S

Publikováno v: bioRxiv

Human pregnancy is frequently accompanied by nausea and vomiting that may become severe and life-threatening, as in hyperemesis gravidarum (HG), the cause of which is unknown. Growth Differentiation Factor-15 (GDF15), a hormone known to act on the hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2811c5e20551036e23638b95c142a0ec
https://europepmc.org/articles/PMC10312505/

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Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy.

Autor: Fejzo M; Department of Obstetrics and Gynaecology, Keck School of Medicine, University of Southern California, Los Angeles, CA., Rocha N; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Cimino I; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Lockhart SM; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Petry C; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Kay RG; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Peptidomics and Proteomics Core Facility, Level 4, Wellcome-MRC Institute of Metabolic Science, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom., Burling K; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Core Biochemical Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Barker P; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Core Biochemical Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., George AL; Peptidomics and Proteomics Core Facility, Level 4, Wellcome-MRC Institute of Metabolic Science, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom., Yasara N; Department of Paediatrics, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama, 11010, Sri Lanka., Premawardhena A; Adolescent and Adult Thalassaemia Care Center (University Medical Unit), North Colombo Teaching Hospital, Kadawatha, Sri Lanka.; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Gong S; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Cook E; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Rainbow K; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Withers DJ; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Cortessis V; Department of Obstetrics and Gynaecology, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California., Mullin PM; Department of Obstetrics and Gynaecology, Keck School of Medicine, University of Southern California, Los Angeles, CA., MacGibbon KW; Hyperemesis Education and Research Foundation, Clackamas, OR., Jin E; Department of Obstetrics and Gynaecology, Keck School of Medicine, University of Southern California, Los Angeles, CA., Kam A; Department of Obstetrics and Gynaecology, Keck School of Medicine, University of Southern California, Los Angeles, CA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Tzoneva G; Regeneron Genetics Center, Tarrytown, NY, USA., Gribble FM; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Yeo G; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Lam B; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Saudek V; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Hughes IA; Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, University of Cambridge, Cambridge, UK., Ong KK; Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, University of Cambridge, Cambridge, UK.; MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Perry J; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Sutton Cole A; Department of Obstetrics and Gynaecology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Baumgarten M; Department of Obstetrics and Gynaecology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Welsh P; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Sattar N; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Smith G; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Charnock Jones DS; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Coll AP; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Meek CL; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Mettananda S; Department of Paediatrics, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama, 11010, Sri Lanka.; University Paediatrics Unit, Colombo North Teaching Hospital, Ragama, Sri Lanka., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU,16, UK., Mancuso N; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California.; Department of Quantitative and Computational Biology, University of Southern California.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California., O'Rahilly S; Medical Research Council (MRC) Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. so104@medschl.cam.ac.uk.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 04. Date of Electronic Publication: 2023 Jun 04.