Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yaroslav Staroseletz"'
Autor:
Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova
Publikováno v:
Molecules, Vol 26, Iss 6, p 1732 (2021)
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are curren
Externí odkaz:
https://doaj.org/article/b6e2f145e1c94415a4b34c09e00a009c
Autor:
Bahareh Amirloo, Yaroslav Staroseletz, Sameen Yousaf, David J Clarke, Tom Brown, Harmesh Aojula, Marina A Zenkova, Elena V Bichenkova
Publikováno v:
Nucleic Acids Research
Amirloo, B, Staroseletz, Y, Yousaf, S, Clarke, D J, Brown, T, Aojula, H, Zenkova, M A & Bichenkova, E V 2021, ' “Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates ', Nucleic acids research . https://doi.org/10.1093/nar/gkab1273
Amirloo, B, Staroseletz, Y, Yousaf, S, Clarke, D J, Brown, T, Aojula, H, Zenkova, M A & Bichenkova, E V 2021, ' “Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates ', Nucleic acids research . https://doi.org/10.1093/nar/gkab1273
Antisense sequence-specific knockdown of pathogenic RNA offers opportunities to find new solutions for therapeutic treatments. However, to gain a desired therapeutic effect, the multiple turnover catalysis is critical to inactivate many copies of eme
Autor:
Marina A. Zenkova, David Clarke, Tom Brown, Bahareh Amirloo, Kepa K. Burusco, Alexander A. Lomzov, Aled Williams, Elena V. Bichenkova, Yaroslav Staroseletz
Publikováno v:
Staroseletz, Y, Amirloo, B, Williams, A, Lomzov, A, Burusco, K, Clarke, D J, Brown, T, Zenkova, M A & Bichenkova, E 2020, ' Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates ', Nucleic acids research, vol. 48, no. 19, pp. 10662-10679 . https://doi.org/10.1093/nar/gkaa780
University of Manchester-PURE
Staroseletz, Y, Amirloo, B, Williams, A, Lomzov, A, Burusco-Goni, K, Clarke, D, Brown, T, Zenkova, M A & Bichenkova, E 2020, ' Strict conformational demands of RNA cleavage in bulgeloops created by peptidyl-oligonucleotide conjugates ', Nucleic Acids Res, vol. 48, no. 19, pp. 10662-10679 . < https://doi.org/10.1093/nar/gkaa780 >
Nucleic Acids Research
University of Manchester-PURE
Staroseletz, Y, Amirloo, B, Williams, A, Lomzov, A, Burusco-Goni, K, Clarke, D, Brown, T, Zenkova, M A & Bichenkova, E 2020, ' Strict conformational demands of RNA cleavage in bulgeloops created by peptidyl-oligonucleotide conjugates ', Nucleic Acids Res, vol. 48, no. 19, pp. 10662-10679 . < https://doi.org/10.1093/nar/gkaa780 >
Nucleic Acids Research
Potent knockdown of pathogenic RNA in vivo is an urgent health need unmet by both small-molecule and biologic drugs. ‘Smart’ supramolecular assembly of catalysts offers precise recognition and potent destruction of targeted RNA, hitherto not foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3370e00e689f01039fccc16fa1d0b0f
https://www.research.manchester.ac.uk/portal/en/publications/strict-conformational-demands-of-rna-cleavage-in-bulgeloops-created-by-peptidyloligonucleotide-conjugates(faa0502c-dbe3-4266-83ca-0e4fa9f90b67).html
https://www.research.manchester.ac.uk/portal/en/publications/strict-conformational-demands-of-rna-cleavage-in-bulgeloops-created-by-peptidyloligonucleotide-conjugates(faa0502c-dbe3-4266-83ca-0e4fa9f90b67).html
Autor:
Svetlana Gaponova, O. A. Patutina, Daria Chiglintseva, Thomas Heyman, Yaroslav Staroseletz, Bahareh Amirloo, Elena V. Bichenkova, Marina A. Zenkova
Publikováno v:
Molecules
Staroseletz, Y, Gaponova, S, Patutina, O, Bichenkova, E, Amirloo, B, Heyman, T, Chiglintseva, D & Zenkova, M 2021, ' Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences ', Molecules, vol. 26, no. 6, 1732 . https://doi.org/10.3390/molecules26061732
Molecules, Vol 26, Iss 1732, p 1732 (2021)
Staroseletz, Y, Gaponova, S, Patutina, O, Bichenkova, E, Amirloo, B, Heyman, T, Chiglintseva, D & Zenkova, M 2021, ' Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences ', Molecules, vol. 26, no. 6, 1732 . https://doi.org/10.3390/molecules26061732
Molecules, Vol 26, Iss 1732, p 1732 (2021)
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are curren
Autor:
Valentin V. Vlassov, Sergey Nechaev, Elena V. Bichenkova, Marina A. Zenkova, Yaroslav Staroseletz, Richard A. Bryce, Catherine Watson
Publikováno v:
Staroseletz, Y, Nechaev, S, Bichenkova, E, Bryce, R, Watson, C, Vlassov, V & Zenkova, M 2018, ' Non-enzymatic recombination of RNA: Ligation in loops ', Biochimica et Biophysica Acta (BBA)-General Subjects, vol. 1862, no. 3, pp. 705-725 . https://doi.org/10.1016/j.bbagen.2017.10.019
BACKGROUND:While the RNA world hypothesis is widely accepted, it is still far from complete: the existence of self-replicating ribozyme, consisting of potentially hundreds of nucleotides, is a core assumption for the majority of RNA world models. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b0f80d21afac58a8f2a70fb0e89990
https://pure.manchester.ac.uk/ws/files/64519803/BBAGEN_17_763R1_ACCEPTED_manuscript.pdf
https://pure.manchester.ac.uk/ws/files/64519803/BBAGEN_17_763R1_ACCEPTED_manuscript.pdf
Autor:
Yaroslav, Staroseletz, Aled, Williams, Kepa K, Burusco, Irfan, Alibay, Valentin V, Vlassov, Marina A, Zenkova, Elena V, Bichenkova
Publikováno v:
Biomaterials. 112
Traditional therapeutic interventions against abnormal gene expression in disease states at the level of expressed proteins are becoming increasingly difficult due to poor selectivity, off-target effects and associated toxicity. Upstream catalytic ta
Autor:
Aled Williams, Laurent Jeannin, Elena V. Bichenkova, Marina A. Zenkova, Harmesh Aojula, Yaroslav Staroseletz
Publikováno v:
Bioconjugate chemistry. 26(6)
Described here is a new class of peptidyl-oligonucleotide conjugates (POCs) which show efficient cleavage of a target RNA in a sequence-specific manner. Through phosphoramidate attachment of a 17-mer TΨC-targeting oligonucleotide to amphiphilic pept
Autor:
Yaroslav Staroseletz, Elena V. Bichenkova, Marina A. Zenkova, Catherine Watson, Richard A. Bryce
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 33:53-54
Recombination is a significant source of genetic variation amongst RNA viruses and may occur even in the absence of enzymes (Chetverina et al., 1999). Non-enzymatic recombination remains more enigm...
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 33:55-56
Sequence-specific RNA cleavage is an attractive approach for targeting specific messenger RNA sequences encoding pathogenic proteins or micro-RNAs (e.g. miR-21) up-regulated in a number of cancer p...
Autor:
Laurent Jeannin, Aled Williams, Marina A. Zenkova, Elena V. Bichenkova, Harmesh Aojula, Yaroslav Staroseletz
Publikováno v:
Bioconjugate Chemistry. 26:1862-1862