Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yaroslav A. Kainov"'
Autor:
Yaroslav A. Kainov, Eugene V. Makeyev
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns a
Externí odkaz:
https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff
Autor:
Yaroslav A. Kainov, Eugene V. Makeyev
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Kainov, Y & Makeyev, E 2020, ' A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells ', Nature Communications, vol. 11, no. 1, 361 . https://doi.org/10.1038/s41467-019-14204-z
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Kainov, Y & Makeyev, E 2020, ' A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells ', Nature Communications, vol. 11, no. 1, 361 . https://doi.org/10.1038/s41467-019-14204-z
Eukaryotic gene expression relies on extensive crosstalk between transcription and RNA processing. Changes in this composite regulation network may provide an important means for shaping cell type-specific transcriptomes. Here we show that the RNA-as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41bbbb38626c16d0038208bcba01660
https://pubmed.ncbi.nlm.nih.gov/31953406
https://pubmed.ncbi.nlm.nih.gov/31953406
Autor:
Irina Favorskaya, Andrei Komelkov, Yaroslav A. Kainov, I. B. Zborovskaya, Galina Chemeris, Elena M. Tchevkina
Publikováno v:
Tumor Biology. 35:10295-10300
The impairment of retinoic acid (RA)-dependent signaling is a frequent event during carcinogenesis. Cellular retinoic acid-binding proteins (CRABP1 and CRABP2) are important modulators of RA activity. Up to date, the role of these proteins in cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852527d1b24748cdb71b8cff9bf72be3
https://doi.org/10.1007/s13277-014-2348-4
https://doi.org/10.1007/s13277-014-2348-4
Autor:
Galina Chemeris, Lyubov S Trukhanova, I. B. Zborovskaya, Elina Zueva, Yaroslav A. Kainov, Anna Zhuravskaya, Vera Delektorskaya, Elena M. Tchevkina, Natalya Dyakova, Bertrand Tavitian, A. V. Komelkov, Irina Favorskaya
Publikováno v:
Cell Cycle. 13:1530-1539
CRABP1 (cellular retinoic acid binding protein 1) belongs to the family of fatty acid binding proteins. Retinoic acid binding is the only known functional activity of this protein. The role of CRABP1 in human carcinogenesis remains poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6a5ce08aa761bc0e25212a7b5c1582
https://doi.org/10.4161/cc.28475
https://doi.org/10.4161/cc.28475
Autor:
Katherine M, Collins, Yaroslav A, Kainov, Evangelos, Christodolou, Debashish, Ray, Quaid, Morris, Timothy, Hughes, Ian A, Taylor, Eugene V, Makeyev, Andres, Ramos
Publikováno v:
Nucleic Acids Research
RBM10 is an RNA-binding protein that plays an essential role in development and is frequently mutated in the context of human disease. RBM10 recognizes a diverse set of RNA motifs in introns and exons and regulates alternative splicing. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f96d7991ce68577a090aa2ca2a9b520
https://pubmed.ncbi.nlm.nih.gov/28379442
https://pubmed.ncbi.nlm.nih.gov/28379442
Autor:
Yaroslav A. Kainov, Sergey Naumenko, Vasily N. Aushev, Georgii A. Bazykin, Elena M. Tchevkina
Publikováno v:
Kainov, Y A, Aushev, V N, Naumenko, S A, Tchevkina, E M & Bazykin, G A 2016, ' Complex Selection on Human Polyadenylation Signals Revealed by Polymorphism and Divergence Data ', Genome biology and evolution, vol. 8, no. 6, pp. 1971-1979 . https://doi.org/10.1093/gbe/evw137
Genome Biology and Evolution
Genome Biology and Evolution
Polyadenylation is a step of mRNA processing which is crucial for its expression and stability. The major polyadenylation signal (PAS) represents a nucleotide hexamer that adheres to the AATAAA consensus sequence. Over a half of human genes have mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db35d3b436feee65a27b580516cb2ca
https://kclpure.kcl.ac.uk/en/publications/e139b800-3f80-40d6-9a5d-525fef163693
https://kclpure.kcl.ac.uk/en/publications/e139b800-3f80-40d6-9a5d-525fef163693
Publikováno v:
The Journal of biological chemistry. 286(18)
Tropomyosin (Tm) is a two-stranded α-helical coiled-coil protein with a well established role in regulation of actin cytoskeleton and muscle contraction. It is believed that many Tm functions are enabled by its flexibility whose nature has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a36c6ed9ac2e538da78ad57a822b169
http://ora.ox.ac.uk/objects/uuid:3cd35787-61ef-44f7-b1cb-e44ba28fcc8b
http://ora.ox.ac.uk/objects/uuid:3cd35787-61ef-44f7-b1cb-e44ba28fcc8b