Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Yarong Lu"'
Autor:
Mengnan Ding, Yarong Lu, Qing Wen, Chen Xing, Xin Huang, Yifan Zhang, Wei Wang, Chongchong Zhang, Min Zhang, Fanfei Meng, Kun Liu, Guangchao Liu, Lun Song
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Ambient air temperature is a key factor affecting human health. Female reproductive disorders are representative health risk events under low temperature. However, the mechanism involving in cold-induced female reproductive disorders remains
Externí odkaz:
https://doaj.org/article/09fe04abcf07475c954be1b0eecc56ad
Autor:
Mengnan Ding, Yarong Lu, Xin Huang, Chen Xing, Shaojun Hou, Dongxue Wang, Yifan Zhang, Wei Wang, Chongchong Zhang, Min Zhang, Fanfei Meng, Kun Liu, Guangchao Liu, Jincheng Zhao, Lun Song
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
High altitudes or exposure to hypoxia leads to female reproductive disorders. Circadian clocks are intrinsic time-tracking systems that enable organisms to adapt to the Earth’s 24-h light/dark cycle, which can be entrained by other environmental st
Externí odkaz:
https://doaj.org/article/02a43eb0f76f4c7c855b11f33cad5d9b
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 304:G635-G645
The antidiabetic mechanism of bariatric surgery includes specific changes in the secretion of incretins. To identify additional players originating from the gut, we evaluated the effects of duodenal-jejunal bypass (DJB) in morbidly obese Zucker fatty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b54427ecb9f56d6f72a8684727bdd36
https://doi.org/10.1152/ajpgi.00275.2012
https://doi.org/10.1152/ajpgi.00275.2012
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 294:E928-E938
Insulin-like growth factor I (IGF-I) is normally produced from hepatocytes and various other cells and tissues, including the pancreas, and is known to stimulate islet cell replication in vitro, prevent Fas-mediated β-cell destruction and delay the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a061ac4bc3f4e173ae026d5eaaaf1dd9
https://doi.org/10.1152/ajpendo.00606.2007
https://doi.org/10.1152/ajpendo.00606.2007
Publikováno v:
Endocrine‚ Metabolic & Immune Disorders-Drug Targets. 8:1-10
Reg proteins constitute a conserved family in human and rodents; their production in the pancreas (including the islets of Langerhans) is induced upon beta-cell damage. While some members of the family (Reg1 and islet neogenesis-associated protein, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98ecdc62bd071bfa72ccfd56c96a88f
https://doi.org/10.2174/187153008783928361
https://doi.org/10.2174/187153008783928361
Publikováno v:
American Journal of Physiology. Endocrinology and Metabolism, Vol. 291, No 1 (2006) pp. E50-58
We have recently reported that Pdx1-Cre-mediated whole pancreas inactivation of IGF-I gene [in pancreatic-specific IGF-I gene-deficient (PID) mice] results in increased β-cell mass and significant protection against both type 1 and type 2 diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed3df9336b6996173517120d03ee0c4
https://doi.org/10.1152/ajpendo.00596.2005
https://doi.org/10.1152/ajpendo.00596.2005
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 289:E288-E295
To explore the limitations of the liver-specific IGF-I gene-deficient (LID) model and to further evaluate the role of endocrine IGF-I in early postnatal life and old age, we have studied these mice during the prepubertal period (from birth to 3 wk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaaf10a17cf5e79282dbdf914c34605
https://doi.org/10.1152/ajpendo.00494.2004
https://doi.org/10.1152/ajpendo.00494.2004
Autor:
Daniel Houle, Zhengyi Tang, Katie Robertson, Jun-Li Liu, Yubin Guo, Yarong Lu, Ye Lauren Liu, John J. Kopchick
Publikováno v:
Endocrinology. 146:2602-2609
Both GH and IGF-I stimulate islet cell growth, inhibit cell apoptosis, and regulate insulin biosynthesis and secretion. GH receptor gene deficiency (GHR(-/-)) caused diminished pancreatic islet cell mass and serum insulin level and elevated insulin s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08166770cd1800ce2cfcc1463ee25893
https://doi.org/10.1210/en.2004-1203
https://doi.org/10.1210/en.2004-1203
Publikováno v:
Diabetes, Vol. 53, No 12 (2004) pp. 3131-3141
The dogma that IGF-I stimulates pancreatic islet growth has been challenged by combinational targeting of IGF or IGF-IR (IGF receptor) genes as well as β-cell–specific IGF-IR gene deficiency, which caused no defect in islet cell growth. To assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e895839e90a100307a1df12908a0bd
https://doi.org/10.2337/diabetes.53.12.3131
https://doi.org/10.2337/diabetes.53.12.3131
Publikováno v:
Molecular and Cellular Endocrinology. 204:31-42
Liver-specific IGF-I gene deficient (LID) mice exhibit pancreatic islet hyperplasia and insulin resistance. To clarify their causal relationship, we studied age-dependent changes in these two aspects and the response to beta-cell damage caused by str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79182ea4ca35f67d6e9e8a63355de788
https://doi.org/10.1016/s0303-7207(03)00145-x
https://doi.org/10.1016/s0303-7207(03)00145-x