Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Yaron Shav-Tal"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
There is little information on export directionality of RNA passing through the nuclear pore complex in human cells. Here, the authors examine single RNA molecules in transit, to demonstrate 5’-first directionality for the export of mRNA and lncRNA
Externí odkaz:
https://doaj.org/article/28670f4f5e2d4e85afbb7aa7f6e4c8b4
A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing
Autor:
Roi Isaac, Yaron Vinik, Martin Mikl, Shani Nadav-Eliyahu, Hadas Shatz-Azoulay, Adi Yaakobi, Natalie DeForest, Amit R. Majithia, Nicholas J.G. Webster, Yaron Shav-Tal, Eytan Elhanany, Yehiel Zick
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105270- (2022)
Summary: The seven-transmembrane superfamily member 3 protein (TM7SF3) is a p53-regulated homeostatic factor that attenuates cellular stress and the unfolded protein response. Here we show that TM7SF3 localizes to nuclear speckles; eukaryotic nuclear
Externí odkaz:
https://doaj.org/article/d368cbd385c84aec818ba9cba0005b80
Autor:
Sarah E. Hasenson, Ella Alkalay, Mohammad K. Atrash, Alon Boocholez, Julianna Gershbaum, Hodaya Hochberg-Laufer, Yaron Shav-Tal
Publikováno v:
Cells, Vol 11, Iss 12, p 1942 (2022)
Nuclear speckles are nuclear bodies containing RNA-binding proteins as well as RNAs including long non-coding RNAs (lncRNAs). Maternally expressed gene 3 (MEG3) is a nuclear retained lncRNA found to associate with nuclear speckles. To understand the
Externí odkaz:
https://doaj.org/article/1f9c75d9e8c049789e9af9c07a61deaf
Autor:
Naama Sebbag-Sznajder, Yehuda Brody, Hodaya Hochberg-Laufer, Yaron Shav-Tal, Joseph Sperling, Ruth Sperling
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Splicing and alternative splicing of pre-mRNA are key sources in the formation of diversity in the human proteome. These processes have a central role in the regulation of the gene expression pathway. Yet, how spliceosomes are assembled on a multi-in
Externí odkaz:
https://doaj.org/article/d5c586630ffd41038fe7ba677882f0c0
Autor:
Hodaya Hochberg-Laufer, Noa Neufeld, Yehuda Brody, Shani Nadav-Eliyahu, Rakefet Ben-Yishay, Yaron Shav-Tal
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008459 (2019)
Gene expression dynamics can be measured in single living cells. Using a detectable transcriptionally active gene in living cells, we previously found that an mRNA undergoing several splicing events was retained at this gene after transcription until
Externí odkaz:
https://doaj.org/article/20f5516af9214947be87cc631baa8d44
Autor:
Daniela Dünn-Kittenplon, Asaf Ashkenazy-Titelman, Inna Kalt, Jean-Paul Lellouche, Yaron Shav-Tal, Ronit Sarid
Publikováno v:
Viruses, Vol 13, Iss 4, p 597 (2021)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a cancer-related herpesvirus. Like other herpesviruses, the KSHV icosahedral capsid includes a portal vertex, composed of 12 protein subunits encoded by open reading frame (ORF) 43, which enables pa
Externí odkaz:
https://doaj.org/article/f7b08536a0f64a8e9ed6f8743f4fad24
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Identification of the function of proteins is difficult when there are no structurally or biochemically characterized homologs. Here, the authors present an approach that allows the prediction of nucleic-acid binding proteins based on sequence alone,
Externí odkaz:
https://doaj.org/article/c8b8435173fd4ec1ada9d2bf2631624b
Publikováno v:
Cells, Vol 9, Iss 9, p 1958 (2020)
RNA-binding proteins, particularly splicing factors, localize to sub-nuclear domains termed nuclear speckles. During certain viral infections, as the nucleus fills up with replicating virus compartments, host cell chromatin distribution changes, endi
Externí odkaz:
https://doaj.org/article/d1954f71254143889ee483835f8aa372
Autor:
Alon Kalo, Itamar Kanter, Amit Shraga, Jonathan Sheinberger, Hadar Tzemach, Noa Kinor, Robert H. Singer, Timothée Lionnet, Yaron Shav-Tal
Publikováno v:
Cell Reports, Vol 11, Iss 3, Pp 419-432 (2015)
The transcriptional response of β-actin to extra-cellular stimuli is a paradigm for transcription factor complex assembly and regulation. Serum induction leads to a precisely timed pulse of β-actin transcription in the cell population. Actin protei
Externí odkaz:
https://doaj.org/article/1bbd4d4d9d534e809ada382ad6b88c81
Autor:
Pinhas Kafri, Sarah E Hasenson, Itamar Kanter, Jonathan Sheinberger, Noa Kinor, Sharon Yunger, Yaron Shav-Tal
Publikováno v:
eLife, Vol 5 (2016)
Signal propagation from the cell membrane to a promoter can induce gene expression. To examine signal transmission through sub-cellular compartments and its effect on transcription levels in individual cells within a population, we used the Wnt/β-ca
Externí odkaz:
https://doaj.org/article/039e315350a1465d9ab62d2e4fee5667