Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Yaron, Carmi"'
Autor:
Avishai Maliah, Nadine Santana-Magal, Shivang Parikh, Sagi Gordon, Keren Reshef, Yuval Sade, Aseel Khateeb, Alon Richter, Amit Gutwillig, Roma Parikh, Tamar Golan, Matan Krissi, Manho Na, Gal Binshtok, Paulee Manich, Nadav Elkoshi, Sharon Grisaru-Tal, Valentina Zemser-Werner, Ronen Brenner, Hananya Vaknine, Eran Nizri, Lilach Moyal, Iris Amitay-Laish, Luiza Rosemberg, Ariel Munitz, Noga Kronfeld-Schor, Eric Shifrut, Oren Kobiler, Asaf Madi, Tamar Geiger, Yaron Carmi, Carmit Levy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract T cell inhibitory mechanisms prevent autoimmune reactions, while cancer immunotherapy aims to remove these inhibitory signals. Chronic ultraviolet (UV) exposure attenuates autoimmunity through promotion of poorly understood immune-suppressiv
Externí odkaz:
https://doaj.org/article/558f6188a6ba4158b35fee08d311324d
Autor:
Leen Farhat-Younis, Manho Na, Amichai Zarfin, Aseel Khateeb, Nadine Santana-Magal, Alon Richter, Amit Gutwillig, Diana Rasoulouniriana, Annette Gleiberman, Lir Beck, Tamar Giger, Avraham Ashkenazi, Adi Barzel, Peleg Rider, Yaron Carmi
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/f9a3adc13def42b0b29b48a9f758942d
Autor:
Leen Farhat-Younis, Manho Na, Amichai Zarfin, Aseel Khateeb, Nadine Santana-Magal, Alon Richter, Amit Gutwillig, Diana Rasoulouniriana, Annette Gleiberman, Lir Beck, Tamar Giger, Avraham Ashkenazi, Adi Barzel, Peleg Rider, Yaron Carmi
Publikováno v:
eLife, Vol 12 (2024)
Despite the central role of T cells in tumor immunity, attempts to harness their cytotoxic capacity as a therapy have met limited efficacy, partially as a result of the suppressive microenvironment which limits their migration and activation. In cont
Externí odkaz:
https://doaj.org/article/8b32bc93547d4d01a1ed2717a985adc2
Autor:
Amit Gutwillig, Nadine Santana-Magal, Leen Farhat-Younis, Diana Rasoulouniriana, Asaf Madi, Chen Luxenburg, Jonathan Cohen, Krishnanand Padmanabhan, Noam Shomron, Guy Shapira, Annette Gleiberman, Roma Parikh, Carmit Levy, Meora Feinmesser, Dov Hershkovitz, Valentina Zemser-Werner, Oran Zlotnik, Sanne Kroon, Wolf-Dietrich Hardt, Reno Debets, Nathan Edward Reticker-Flynn, Peleg Rider, Yaron Carmi
Publikováno v:
eLife, Vol 11 (2022)
Despite the remarkable successes of cancer immunotherapies, the majority of patients will experience only partial response followed by relapse of resistant tumors. While treatment resistance has frequently been attributed to clonal selection and immu
Externí odkaz:
https://doaj.org/article/fb33e4cafa1a4209ba1b058808d753b4
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/9f5837f8ea7440a4abaede2b7da5504f
Autor:
Barak Rotblat, Andreas Mock, Jerome Fayette, Limor Cohen, Idan Cohen, Elena Voronov, Jebrane Bouaoud, Lucas Michon, Pierre Saintigny, Luc G T Morris, Manu Prasad, Jonathan Zorea, Sankar Jagadeeshan, Avital B Shnerb, Sooraj Mathukkada, Ofra Novoplansky, Mai Badarni, Ksenia M Yegodayev, Sapir Tzadok, Libor Brezina, Andy Karabajakian, Tomer Cooks, Irit Allon, Orr Dimitstein, Benzion Joshua, Dexin Kong, Maurizio Scaltriti, Yaron Carmi, Cristina Conde-Lopez, Jochen Hess, Ina Kurth, Moshe Elkabets
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 in HNC patients has not shown clinically meaningful activity. Therefore, we aimed to characterize the effect o
Externí odkaz:
https://doaj.org/article/e52b0f83da384bc987314eeb1cc6f2e4
Autor:
Alessio D. Nahmad, Yuval Raviv, Miriam Horovitz-Fried, Ilan Sofer, Tal Akriv, Daniel Nataf, Iris Dotan, Yaron Carmi, David Burstein, Yariv Wine, Itai Benhar, Adi Barzel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Chronic antiretroviral therapy does not eradicate HIV infection. Here, the authors describe a potentially one-shot alternative by engineering B cells to express anti-HIV antibodies and undergo memory retention, isotype switching and clonal expansion
Externí odkaz:
https://doaj.org/article/53cea78635c1437b9150abc735992dd8
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The role of B cells in the tumor microenvironment (TME) has largely been under investigated, and data regarding the antibody repertoire encoded by B cells in the TME and the adjacent lymphoid organs are scarce. Here, we utilized B cell receptor high-
Externí odkaz:
https://doaj.org/article/aeb9898ced6c485ba8d71f8cf442b7b5
Autor:
Diana Rasoulouniriana, Nadine Santana-Magal, Amit Gutwillig, Leen Farhat-Younis, Lior Tal, Sarah Amar, Michael Milyavsky, Siva Sai Naga Anurag Muddineni, Neta Solomon, Hana Shpilt, Shahar Dotan, Noam Pilpel, Claudia Waskow, Meora Feinmesser, Peleg Rider, Yaron Carmi
Publikováno v:
Cancer Immunology Research. :OF1-OF18
The pioneering design of chimeric antigen receptor (CAR) T-cell therapy demonstrated the potential of reprogramming the immune system. Nonetheless, T-cell exhaustion, toxicity, and suppressive microenvironments limit their efficacy in solid tumors. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2450bd40e191e33c039896c5ef96a739
https://doi.org/10.1158/2326-6066.cir-22-0423
https://doi.org/10.1158/2326-6066.cir-22-0423
Autor:
Xiangyue Zhang, Pingping Zheng, Tyler R. Prestwood, Hong Zhang, Yaron Carmi, Lorna L. Tolentino, Nancy Wu, Okmi Choi, Daniel A. Winer, Samuel Strober, Eun-Suk Kang, Michael N. Alonso, Edgar G. Engleman
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Dendritic cells (DCs) are powerful antigen presenting cells, derived from bone marrow progenitors (cDCs) and monocytes (moDCs), that can shape the immune response by priming either proinflammatory or tolerogenic immune effector cells. The cellular me
Externí odkaz:
https://doaj.org/article/f9610ae766284fd3bd7339b7518a6a21