Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Yari Carlomagno"'
Autor:
Aleksandra M. Wojtas, Yari Carlomagno, Jonathon P. Sens, Silvia S. Kang, Tanner D. Jensen, Aishe Kurti, Kelsey E. Baker, Taylor J. Berry, Virginia R. Phillips, Monica Casey Castanedes, Ayesha Awan, Michael DeTure, Cristhoper H. Fernandez De Castro, Ariston L. Librero, Mei Yue, Lillian Daughrity, Karen R. Jansen-West, Casey N. Cook, Dennis W. Dickson, Leonard Petrucelli, John D. Fryer
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract The molecular chaperone Clusterin (CLU) impacts the amyloid pathway in Alzheimer’s disease (AD) but its role in tau pathology is unknown. We observed CLU co-localization with tau aggregates in AD and primary tauopathies and CLU levels were
Externí odkaz:
https://doaj.org/article/fe6771b48e634b8d8a968a11735cfc6c
Autor:
Karen Jansen-West, Tiffany W. Todd, Lillian M. Daughrity, Mei Yue, Jimei Tong, Yari Carlomagno, Giulia Del Rosso, Aishe Kurti, Caroline Y. Jones, Judith A. Dunmore, Monica Castanedes-Casey, Dennis W. Dickson, Zbigniew K. Wszolek, John D. Fryer, Leonard Petrucelli, Mercedes Prudencio
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited cerebellar ataxia caused by the expansion of a polyglutamine (polyQ) repeat in the gene encoding ATXN3. The polyQ expansion induces protein inclusion formation in the neurons of patients
Externí odkaz:
https://doaj.org/article/93c536b37c164026a09cc9898bc89801
Autor:
Giulia del Rosso, Yari Carlomagno, Tiffany W. Todd, Caroline Y. Jones, Mercedes Prudencio, Lillian M. Daughrity, Mei Yue, Karen Jansen-West, Jimei Tong, Wei Shao, Yanwei Wu, Monica Castanedes-Casey, Lilia Tabassian, Björn Oskarsson, Karen Ling, Frank Rigo, Dennis W. Dickson, Tso-Pang Yao, Leonard Petrucelli, Casey N. Cook, Yong Jie Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
The aberrant translation of a repeat expansion in chromosome 9 open reading frame 72 (C9orf72), the most common cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), results in the accumulation of toxic dipeptide repeat (DPR
Externí odkaz:
https://doaj.org/article/82dcc1ca691c4a8c903043790d6753ad
Autor:
Dah-eun Chloe Chung, Yari Carlomagno, Casey N. Cook, Karen Jansen-West, Lillian Daughrity, Laura J. Lewis-Tuffin, Monica Castanedes-Casey, Michael DeTure, Dennis W. Dickson, Leonard Petrucelli
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. They are clinically and pathologically heterogeneous depending on the isoform of tau protein that accumulates
Externí odkaz:
https://doaj.org/article/76089d87ed404a068675109efa344743
Autor:
Yari Carlomagno, Dah-eun Chloe Chung, Mei Yue, Aishe Kurti, Nicole M. Avendano, Monica Castanedes-Casey, Kelly M. Hinkle, Karen Jansen-West, Lillian M. Daughrity, Jimei Tong, Virginia Phillips, Rosa Rademakers, Michael DeTure, John D. Fryer, Dennis W. Dickson, Leonard Petrucelli, Casey Cook
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Pathogenic mutations in the tau gene (microtubule associated protein tau, MAPT) are linked to the onset of tauopathy, but the A152T variant is unique in acting as a risk factor for a range of disorders including Alzheimer’s disease (AD), p
Externí odkaz:
https://doaj.org/article/01ef1476c69f420aa2d92a6235cfe2dd
Autor:
Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-9 (2017)
Abstract Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has been shown to regulate brain PG
Externí odkaz:
https://doaj.org/article/5c43b4a31fdf4d9685d4506f92648711
Autor:
Yari Carlomagno, Yongjie Zhang, Mary Davis, Wen-Lang Lin, Casey Cook, Judy Dunmore, William Tay, Kyle Menkosky, Xiangkun Cao, Leonard Petrucelli, Michael Deture
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90452 (2014)
Trans-activation Response DNA-binding Protein-43 (TDP-43) lesions are observed in Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration with ubiquitin inclusions (FTLD-TDP) and 25-50% of Alzheimer's Disease (AD) cases. These abnormal
Externí odkaz:
https://doaj.org/article/3510b5bd547a410d9f499cd3ea26c3fb
Autor:
Alexandra Vaccaro, Arnaud Tauffenberger, Peter E A Ash, Yari Carlomagno, Leonard Petrucelli, J Alex Parker
Publikováno v:
PLoS Genetics, Vol 8, Iss 7, p e1002806 (2012)
TDP-43 is a multifunctional nucleic acid binding protein linked to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia. To learn more about the normal biological and abnormal pathological role
Externí odkaz:
https://doaj.org/article/cf353680b8cc493996134dfcf2d0b626
Autor:
Jannifer H Lee, Dmytro Morderer, Bilal Khalil, Feilin Liu, Chih‐Wei Tsai, Cara L Croft, Yari Carlomagno, Michael DeTure, Michelle Salemi, Casey Cook, Brett Phinney, Dennis W. Dickson, Todd E Golde, Leonard Petrucelli, Wilfried Rossoll
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Rina Hashimoto, Jay A. van Gerpen, Yari Carlomagno, Mark S. LeDoux, Ronald F. Pfeiffer, Joseph H. Friedman, Yuka Koike, Samuel S. Giles, Ashley B. Pena, Leonard Petrucelli, Karen Jansen-West, Jaimin S. Shah, Josephine F. Huang, Philip W. Tipton, Jacek Zaremba, Venka Veerappan, Zbigniew K. Wszolek, John D. Fryer, Ikuko Aiba, Klaas J. Wierenga, Judith A. Dunmore, Jan O. Aasly, Ryan J. Uitti, Yuping Song, Rana Hanna Al-Shaikh, Mercedes Prudencio
Publikováno v:
Parkinsonism & related disorders
Introduction Accumulation of polyglutamine (polyQ) ataxin-3 (ATXN3) contributes to the pathobiology of spinocerebellar ataxia type 3 (SCA3). Recently, we showed that polyQ ATXN3 is elevated in the plasma and cerebrospinal fluid (CSF) of SCA3 patients