Zinc supplementation inhibits complement activation in age-related macular degeneration.

Autor: Dzenita Smailhodzic, Freekje van Asten, Anna M Blom, Frida C Mohlin, Anneke I den Hollander, Johannes P H van de Ven, Ramon A C van Huet, Joannes M M Groenewoud, Yuan Tian, Tos T J M Berendschot, Yara T E Lechanteur, Sascha Fauser, Chris de Bruijn, Mohamed R Daha, Gert Jan van der Wilt, Carel B Hoyng, B Jeroen Klevering

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112682 (2014)

UnlabelledAge-related macular degeneration (AMD) is the leading cause of blindness in the Western world. AMD is a multifactorial disorder but complement-mediated inflammation at the level of the retina plays a pivotal role. Oral zinc supplementation

Externí odkaz: https://doaj.org/article/e0071239818d40fb8f9a03a69f7715c0

[Treatment of age-related macular degeneration: new insights and developments]

Autor: Francesco, Cinque, Carel B, Hoyng, Yara T E, Lechanteur

Publikováno v: Nederlands tijdschrift voor geneeskunde. 166

Age-related macular degeneration (AMD) is a highly prevalent retinal disease in the elderly with a potential deleterious effect on quality of life. Since the introduction of intra-ocular anti-vascular endothelial growth factor (anti-VEGF) injections,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71648a3f88f695e952ed7b279255fb0c
https://pubmed.ncbi.nlm.nih.gov/35499594

Systemic complement levels in patients with age-related macular degeneration carrying rare or low-frequency variants in the CFH gene

Autor: Sarah de Jong, Carel B. Hoyng, Lambert P J W van den Heuvel, Anita de Breuk, Elena B. Volokhina, Yara T. E. Lechanteur, Alejandro Garanto, Sascha Fauser, Suresh Katti, Bjorn Bakker, Anneke I. den Hollander

Publikováno v: Human Molecular Genetics, 31, 455-70
Human Molecular Genetics, 31, 3, pp. 455-70

Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. Genetic variants in the complement factor H (CFH) gene are associated with AMD, but the functional consequences of many of these variants a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f32a9ecf69385e49c5e9c94afcf04f0
http://hdl.handle.net/2066/248812

Implications of genetic variation in the complement system in age-related macular degeneration

Autor: Anita de Breuk, Sarah de Jong, Lambert P J W van den Heuvel, Yara T. E. Lechanteur, Anneke I. den Hollander, Giuliana Gagliardi, Suresh Katti, Alejandro Garanto, Elena B. Volokhina

Publikováno v: Progress in Retinal and Eye Research, 84

Contains fulltext : 237835.pdf (Publisher’s version ) (Open Access) Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly in the Western world. While AMD is a multifactorial disease, the complement system was ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f9d6315a94c3fde9720e41de5bac6d

Complement activation levels are related to disease stage in AMD

Autor: Dzenita Smailhodzic, B. Jeroen Klevering, Tina Schick, Thomas J. Heesterbeek, Mohamed R. Daha, Yara T. E. Lechanteur, Sandra Liakopoulos, Lebriz Altay, Carel B. Hoyng, Laura Lorés-Motta, Eiko K. de Jong, Anneke I. den Hollander

Publikováno v: Investigative Ophthalmology and Visual Science, 61
7th International Symposium on AMD: Age-related Macular Degeneration-Understanding Pathogenetic Mechanisms of Disease; 20190920-20190921; Baden-Baden; DOC19amd15 /20200205/
Investigative Ophthalmology and Visual Science, 61, 3
Investigative Ophthalmology & Visual Science
Investigative Ophthalmology & Visual Science, 61(3). ASSOC RESEARCH VISION OPHTHALMOLOGY INC

Background: To study the levels of complement activation in different disease stages of age-related macular degeneration (AMD) and the influence of genetic polymorphisms in complement genes. Methods: We included 797 AMD patients and 945 controls from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233cf908324edab45c5fae68caee3628
https://hdl.handle.net/1887/3185008