Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yara El-Dash"'
Publikováno v:
Acta Chimica Slovenica, Vol 64, Iss 1, Pp 102-116 (2017)
A new series of 4-benzyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a] pyrimidines was synthesized motivated by the widely reported anticancer activity of thieno[2,3-d]pyrimidines and triazolothienopyrimidines. The in vitro cytotoxic
Externí odkaz:
https://doaj.org/article/9460edad7d1f4f209be37966eda52240
Publikováno v:
Bioorganic Chemistry. 125:105861
A series of novel thieno[2,3-d]pyrimidine derivatives was designed and synthesized based on multitarget directed drug design strategy. All the newly synthesized compounds were evaluated for their antiproliferative activity in the National Cancer Inst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d4db5c8e5878c050a9ff3e6b239970
https://doi.org/10.1016/j.bioorg.2022.105861
https://doi.org/10.1016/j.bioorg.2022.105861
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 18(4)
Background: The reported binding mode of ibuprofen in the COX-2 binding site indicated that the carboxylic group binds with Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel and does not extend into the pocket. This accounted for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b3412b33e06444dada4a0e27a59690
https://pubmed.ncbi.nlm.nih.gov/34370644
https://pubmed.ncbi.nlm.nih.gov/34370644
Publikováno v:
Bioorganic chemistry. 107
Two novel series derived from nicotinic acid were synthesized and evaluated for their inhibitory activity against cyclooxygenases COX-1 and COX-2, and their selectivity indices were determined. Celecoxib, diclofenac and indomethacin were used as refe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29374ae4144544fbb843e9e5df6bb6e
https://pubmed.ncbi.nlm.nih.gov/33454504
https://pubmed.ncbi.nlm.nih.gov/33454504
Publikováno v:
Bioorganic Chemistry. 114:105137
A series of novel hybrid compounds of hexahydrobenzo[4,5]thieno[2,3-d]pyrimidine with aminothiazole scaffolds were synthesized. The synthesized compounds were evaluated for their cytotoxic activity against the NCI-60 human tumor cell line panel. Comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24def919f632aef4dc0e141e92601281
https://doi.org/10.1016/j.bioorg.2021.105137
https://doi.org/10.1016/j.bioorg.2021.105137
Publikováno v:
Archiv der PharmazieREFERENCES. 353(4)
A series of novel diaryl urea pyrazolopyrimidine derivatives was designed and synthesized. All the synthesized compounds were evaluated for cytotoxic activity by the National Cancer Institute. A significant antiproliferative activity at a 10-µM dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861516403e131c9374a088b1e3a16c31
https://pubmed.ncbi.nlm.nih.gov/32091161
https://pubmed.ncbi.nlm.nih.gov/32091161
Publikováno v:
OALib. :1-7
The present study focused on synthesizing a series of novel derivatives of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl) acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97432621d7916c38275985134f583640
https://doi.org/10.4236/oalib.1102876
https://doi.org/10.4236/oalib.1102876
Publikováno v:
Acta Chimica Slovenica, Vol 64, Iss 1, Pp 102-116 (2017)
A new series of 4-benzyl-6,7,8,9-tetrahydro[1]benzothieno[3,2- e ][1,2,4]triazolo[4,3- a ] pyrimidines was synthesized motivated by the widely reported anticancer activity of thieno[2,3- d ]pyrimidines and triazolothienopyrimidines. The in vitro cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbba2f36f3ddee76fc1cc392a2a1e7c
https://pubmed.ncbi.nlm.nih.gov/28380219
https://pubmed.ncbi.nlm.nih.gov/28380219
Publikováno v:
European Journal of Medicinal Chemistry. 60:57-63
Hybrids between phenytoin and thiosemicarbazide, 1,3,4-oxadiazole, 1,3,4-thiadiazole or 1,2,4-triazole were synthesized and tested for anticonvulsant activity. Preliminary anticonvulsant screening was performed using standard maximal electroshock (ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f825b17ce7fccc68f79aec16f80ed69a
https://doi.org/10.1016/j.ejmech.2012.11.025
https://doi.org/10.1016/j.ejmech.2012.11.025
Publikováno v:
Archives of pharmacal research. 35(12)
Synthesis, characterization and anticonvulsant properties of new bivalent ligands derived from phenytoin were described. Initial anticonvulsant screening was performed using maximal electroshock (MES) and pentylenetetrazole (PTZ) screens in mice. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34116705e9ade3214c70095be267b1f
https://pubmed.ncbi.nlm.nih.gov/23263804
https://pubmed.ncbi.nlm.nih.gov/23263804