Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Yaqun Xin"'
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Akademický článek
A urinary assay for mutation and methylation biomarkers in the diagnosis and recurrence prediction of non-muscle invasive bladder cancer patients
Autor: Hai Huang, Ao Liu, Yiming Liang, Yaqun Xin, Jiacheng Liu, Yining Hao, Da Huang, Lu Chen, Wei Li, Guangliang Jiang, Yuhua Huang, Yaoting Xu, Jie Zhang, Tonghui Ma, Danfeng Xu, Yi Gao
Publikováno v: BMC Medicine, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background Currently, the clinical strategy for diagnosis of non-muscle invasive bladder cancer (NMIBC) such as cystoscopy and cytology are invasive and/or with limited accuracy. OncoUrine, a urinary assay for mutation and methylation biomar
Externí odkaz: https://doaj.org/article/c7e51e84278c40399a782437c8dfc6d7
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3
Genomic landscape of microsatellite instability in Chinese tumors: A comparison of Chinese and TCGA cohorts
Autor: Ziyu Li, Yongning Jia, Honglin Zhu, Hongling Yuan, Xiaofang Xing, Yaqun Xin, Tonghui Ma, Fei Pang, Yan Zhang, Ying Hu, Shuqin Jia, Jiafu Ji
Publikováno v: International journal of cancerREFERENCES. 151(8)
Microsatellite instability (MSI) is an important biomarker for predicting the response to immunotherapy and prognosis that mainly results from a defective DNA mismatch repair (MMR) system and strongly correlates with high tumor mutation burden (TMB).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85977f8fc2030e4e4aece15b8889380a
https://pubmed.ncbi.nlm.nih.gov/35567574
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4
Ancestral and derived transcriptional enhancers share regulatory sequence and a pleiotropic site affecting chromatin accessibility
Autor: Elena Osipova, Liucong Ling, Nicolas Gompel, Bettina Mühling, Mariam Museridze, Yann Le Poul, Yaqun Xin, Rita Jaenichen
Publikováno v: Proceedings of the National Academy of Sciences. 117:20636-20644
The diversity of forms in multicellular organisms originates largely from the spatial redeployment of developmental genes [S. B. Carroll, Cell 134, 25-36 (2008)]. Several scenarios can explain the emergence of cis-regulatory elements that govern nove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0152e28ecc443af6d62610fd0c9cf308
https://doi.org/10.1073/pnas.2004003117
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5
Abstract 5751: Comprehensive analysis of POLE/POLD1 variants, MMR deficient/MSI, and tumor mutational burden in Chinese population
Autor: Yongning Jia, Yaqun Xin, Hongling Yuan, Fei Pang, Fei Shan, Shuangxi Li, Honglin Zhu, Ziyu Li
Publikováno v: Cancer Research. 82:5751-5751
Background: Mutations in genes encoding DNA polymerase epsilon (POLE) and delta 1 (POLD1) can lead to defects in the DNA replication, resulting in a hypermutated tumor phenotype, which might help identify potential responders to immunotherapy. This s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03fd064e34cc69ca2be3c0dd4b99a39d
https://doi.org/10.1158/1538-7445.am2022-5751
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6
Abstract 5752: Loss-of-function mutations in ACVR2A are correlated with microsatellite instability in gastric and colorectal cancer
Autor: Yongning Jia, Hongling Yuan, Yaqun Xin, Fei Pang, Fei Shan, Shuangxi Li, Honglin Zhu, Ziyu Li
Publikováno v: Cancer Research. 82:5752-5752
Background: The activin type II receptor (ACVR2), which is a member of the transforming growth factor beta (TGF-β) receptor family, is frequently mutated in colorectal cancer (CRC) and gastric cancer (GC). However, the incidence of ACVR2 mutations i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3cd2a5642af9f6b4bcf084b39a5f5cb
https://doi.org/10.1158/1538-7445.am2022-5752
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7
Genomic alteration in chromatin remodeling genes as a potential predictive biomarker for immunotherapy in gastric cancer
Autor: Yongning Jia, Hongling Yuan, Yaqun Xin, Xiaofang Xing, Ziyu Li, Honglin Zhu
Publikováno v: Journal of Clinical Oncology. 40:e16083-e16083
e16083 Background: Gastric cancer (GC) is the fifth most incident and the fourth deadliest cancer worldwide, and currently immune checkpoint inhibitors have been approved for the treatment of patients with recurrent/metastatic GC. Studies have report
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ecaecd565ced6e79a8fd6ba2fbb6ea1
https://doi.org/10.1200/jco.2022.40.16_suppl.e16083
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8
Pan-cancer analysis of PBRM1 mutation and their association with immune-related biomarkers and prognosis
Autor: Xujun He, Yaqun Xin, Hongling Yuan, Houquan Tao, Qingqing Wang, Honglin Zhu
Publikováno v: Journal of Clinical Oncology. 40:e14536-e14536
e14536 Background: Polybromo 1 ( PBRM1), which is required for the stability of the SWI/SNF chromatin remodeling complex, is often deleted or mutated in clear cell renal cell carcinoma (ccRCC). However, the prognostic value of PBRM1 in ccRCC with imm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a867a78dea970a1fc0840af6f827b383
https://doi.org/10.1200/jco.2022.40.16_suppl.e14536
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9
The Hox gene Antennapedia is essential for wing development in insects
Autor: Chunyan Fang, Yaqun Xin, Tao Sun, Antónia Monteiro, Zhanfeng Ye, Fangyin Dai, Cheng Lu, Xiaoling Tong
Publikováno v: Development (Cambridge, England). 149(2)
A long-standing view in the field of evo-devo is that insect forewings develop without any Hox gene input. The Hox gene Antennapedia (Antp), despite being expressed in the thoracic segments of insects, has no effect on wing development. This view has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03a2322c169a357fd918d29adcfa1a9
https://pubmed.ncbi.nlm.nih.gov/35088829
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10
Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer
Autor: Nicolas Gompel, Yingfei Wang, Elena Osipova, Eamonn Murphy, Remo Rohs, David Bunk, Liucong Ling, Bettina Mühling, Deepak Dharmadhikari, David Hörl, Yann Le Poul, Stephan Preibisch, Heinrich Leonhardt, Hartmann Harz, Benjamin Prud'homme, Yaqun Xin, Rita Jaenichen, Mariam Museridze
Publikováno v: Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (49), pp.eabe2955. ⟨10.1126/sciadv.abe2955⟩
Science Advances, 2020, 6 (49), pp.eabe2955. ⟨10.1126/sciadv.abe2955⟩
A high density of regulatory information encodes a quantitative spatial pattern in a Drosophila transcriptional enhancer.
Developmental enhancers control the expression of genes prefiguring morphological patterns. The activity of an enhancer var
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c96b7c58695f763b23494f96b0f976b
https://hal.archives-ouvertes.fr/hal-03045153/file/LePoul_et_al_2020_HAL.pdf
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