Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yapom, Ratsuda"'
Autor:
Yapom, Ratsuda
α-Synuclein (αSyn) is a small intrinsically disordered protein that drives the progression of a group of neurological disorders known of synucleinopathies, including Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Increa
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716646
Akademický článek
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Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Autor:
Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death called ferroptosis. Importantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5e053db87abb18fb0f8be76bc2e814
Autor:
Ludtmann, Marthe HR, Angelova, Plamena R, Horrocks, Mathew H, Choi, Minee L, Rodrigues, Margarida, Baev, Artyom Y, Berezhnov, Alexey V, Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T, Whiten, Daniel R, Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J, Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V, Klenerman, David, Abramov, Andrey Y, Gandhi, Sonia
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Ludtmann, M HR, Angelova, P R, Horrocks, M H, Choi, M, Rodrigues, M, Baev, A Y, Berezhnov, A V, Yao, Z, Little, D, Banushi, B, Al-Menhali, A S, Ranasinghe, R T, Whiten, D R, Yapom, R, Singh Dolt, K, Devine, M J, Gissen, P, Kunath, T, Jaganjac, M, Pavlov, E V, Klenerman, D, Abramov, A Y & Gandhi, S 2018, ' α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease ', Nature Communications, vol. 9, 2293 . https://doi.org/10.1038/s41467-018-04422-2
Nature Communications
Ludtmann, M HR, Angelova, P R, Horrocks, M H, Choi, M, Rodrigues, M, Baev, A Y, Berezhnov, A V, Yao, Z, Little, D, Banushi, B, Al-Menhali, A S, Ranasinghe, R T, Whiten, D R, Yapom, R, Singh Dolt, K, Devine, M J, Gissen, P, Kunath, T, Jaganjac, M, Pavlov, E V, Klenerman, D, Abramov, A Y & Gandhi, S 2018, ' α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease ', Nature Communications, vol. 9, 2293 . https://doi.org/10.1038/s41467-018-04422-2
Nature Communications
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that aggregation of monom
Akademický článek
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Publikováno v:
68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS); 20170514-20170517; Magdeburg; DOCDI.15.03 /20170609/
Objective: Since the 1960s, there has been some success in targeted medical (L-Dopa) and surgical (deep brain stimulation) treatments for motor symptoms in Parkinson’s disease (PD). However, these are non-disease modifying, each with limitations. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fc3011b16beecb45c4fff2d31dcc53
Akademický článek
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Autor:
Mayxay, Mayfong, Khanthavong, Maniphone, Lindegårdh, Niklas, Keola, Siamphay, Barends, Marion, Pongvongsa, Tiengkham, Yapom, Ratsuda, Annerberg, Anna, Phompida, Samlane, Phetsouvanh, Rattanaxay, White, Nicholas J., Newton, Paul N.
Publikováno v:
Clinical Infectious Diseases; 10/15/2004, Vol. 39 Issue 8, p1139-1147, 9p
Autor:
Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Publikováno v:
Cell Death and Differentiation; May 2021, Vol. 28 Issue: 5 p1755-1755, 1p
Autor:
Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Publikováno v:
Cell Death and Differentiation; September 2020, Vol. 27 Issue: 9 p2747-2747, 1p