Výsledky vyhledávání

Dissertation/ Thesis

Auto-tuning SOS Algorithm for Solving Engineering Problems - A Case Study of Cutting Steel Bars

Autor: YAPING QIU, 邱雅萍

105
In recent decades, information technology was wisely applied in various areas. Many complex engineering problems can be easily solved by metaheuristic algorithm. For example, the problem of steel bars cutting, which is aim to reduce the oddm

Externí odkaz: http://ndltd.ncl.edu.tw/handle/qsqeew

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An Applied Research of Big Data in the Work of Higher Education Students

Autor: Weiqing Li, Jingyi Zhang, Yaping Qiu, Cheng Cao

Publikováno v: Proceedings of the 2022 2nd International Conference on Control and Intelligent Robotics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::563c9550651d5d02af84e7a8aad92c21
https://doi.org/10.1145/3548608.3559308

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Effectiveness of Artificial Intelligence (AI) in Improving Pupils’ Deep Learning in Primary School Mathematics Teaching in Fujian Province

Autor: Yaping Qiu, Junjie Pan, Nor Asniza Ishak

Publikováno v: Computational Intelligence and Neuroscience.

Several primary school students in Fujian Province have perceived studying mathematics as challenging. To deal with this issue, computer technology advancements, specifically artificial intelligence (AI), present an opportunity to evaluate individual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6950ed66dbde9ab97cce4c93a4102d4b

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A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors

Autor: Junzhou Huang, Yang Yu, Liming Dong, Xuemin Cheng, Jiawen Li, Dengfeng Dou, Yu Rong, Jin Li, Yaping Qiu, Zhen Gong, Tingyang Xu, Wei Liu

Publikováno v: ACS Omega
ACS Omega, Vol 6, Iss 35, Pp 22945-22954 (2021)

We have developed a graph-based Variational Autoencoder with Gaussian Mixture hidden space (GraphGMVAE), a deep learning approach for controllable magnitude of scaffold hopping in generative chemistry. It can effectively and accurately generate molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e7e55569ea49c388bdfb5e564c012a
https://pubmed.ncbi.nlm.nih.gov/34514265

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SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain is Subject to Negative Selection with Predicted Positive Selection Mutations

Autor: Min Pan, Li You, Ye Wang, Yaping Qiu, Jianan Xu, Jin Li, Li Yang, Zhen Gong, Deng Lei, Huiping Yang

COVID-19 is a highly contagious disease caused by a novel coronavirus SARS-CoV-2. The interaction between SARS-CoV-2 spike protein and the host cell surface receptor ACE2 is responsible for mediating SARS-CoV-2 infection. By analyzing the spike-hACE2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59de983ae5151470ea74054eb084bc6
https://doi.org/10.1101/2020.05.04.077842

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Discovery of promising FtsZ inhibitors by E-pharmacophore, 3D-QSAR, molecular docking study, and molecular dynamics simulation

Autor: Yanqiu Hu, Lu Zhou, Yaping Qiu, Yinfeng Bao

Publikováno v: Journal of receptor and signal transduction research. 39(2)

Filamentous temperature-sensitive protein Z (FtsZ), playing a key role in bacterial cell division, is regarded as a promising target for the design of antimicrobial agent. This study is looking for potential high-efficiency FtsZ inhibitors. Ligand-ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d7f20aa659d890b47ceefd2710bbb6
https://pubmed.ncbi.nlm.nih.gov/31355691

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Discover potential inhibitors for PFKFB3 using 3D-QSAR, virtual screening, molecular docking and molecular dynamics simulation

Autor: Yanqiu Hu, Duoqian Dai, Yinfeng Bao, Yaping Qiu, Lu Zhou, Xiaohong Zhu

Publikováno v: Journal of receptor and signal transduction research. 38(5-6)

The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a master regulator of glycolysis in cancer cells by synthesizing fructose-2,6-bisphosphate (F-2,6-BP), a potent allosteric activator of phosphofructokinase-1 (PFK-1), which is a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e0296e3113f7abf2f685c53b9be3b7
https://pubmed.ncbi.nlm.nih.gov/30822195

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Pharmacophore modeling, multiple docking, and molecular dynamics studies on Wee1 kinase inhibitors

Autor: Yanqiu Hu, Duoqian Dai, Yinfeng Bao, Xiaohong Zhu, Yaping Qiu, Lu Zhou

Publikováno v: Journal of biomolecular structuredynamics. 37(10)

Wee1-like protein kinase (Wee1) is a tyrosine kinase that regulates the G2 checkpoint and prevents entry into mitosis in response to DNA damage. Based on a series of signaling pathways initiated by Wee1, Wee1 has been recognized as a potential target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfcc50777a674616b55a3fa0184edac
https://pubmed.ncbi.nlm.nih.gov/30052133

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