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The study of targeted blocking SDF-1/CXCR4 signaling pathway with three antagonists on MMPs, type II collagen, and aggrecan levels in articular cartilage of guinea pigs

Autor: Guoliang Wang, Yanlin Li, Xuhan Meng, Xiao Yang, Yaoyu Xiang

Publikováno v: Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-7 (2020)

Abstract Objective To explore the possibility and mechanism of targeted blocking SDF-1/CXCR4 signaling pathway using three antagonists TN14003, T140, and AMD3100 in vivo, and to investigate the function of three antagonists in delay degeneration proc

Externí odkaz: https://doaj.org/article/9a453747209243958e62b9dd17cd4812

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Long noncoding and micro-RNA expression in a model of articular chondrocyte degeneration induced by stromal cell-derived factor-1

Autor: Guoliang Wang, Lu He, Yaoyu Xiang, Di Jia, Yanlin Li

Publikováno v: Asian Biomedicine. 16:169-179

Background Gene regulatory network analysis has found that long noncoding ribonucleic acids (lncRNAs) are strongly associated with the pathogenesis of osteoarthritis. Objectives To determine the differential expression of lncRNAs and microRNAs (miRNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::851b36f4c246fdda371dff7726c69242
https://doi.org/10.2478/abm-2022-0021

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