Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Yaoyao Shen"'
Autor:
Jing Lu, Huiying Qiu, Ying Wang, Xin Zhou, Haiping Dai, Xuzhang Lu, Xiaofei Yang, Bin Gu, Ming Hong, Miao Miao, Ruinan Lu, Jun Wang, Qian Wu, Mengxing Xue, Yun Wang, Ailing Deng, Yaoyao Shen, Yin Liu, Xueqing Dou, Yutian Lei, Depei Wu, Yu Zhu, Suning Chen
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Blinatumomab has emerged as a promising component of first-line therapy for acute B-cell precursor lymphoblastic leukemia (BCP-ALL), bolstering treatment efficacy. To mitigate CD19 selection pressure and reduce the incidence of blinatumomab-
Externí odkaz:
https://doaj.org/article/86618ecde62b4bd2b7a24b4410fdab60
Autor:
Hongrui Zhu, Yamin Gao, Liyun Liu, Mengyu Tao, Xiao Lin, Yijia Cheng, Yaoyao Shen, Haitao Xue, Li Guan, Huimin Zhao, Li Liu, Shuping Wang, Fan Yang, Yongjun Zhou, Hongze Liao, Fan Sun, Houwen Lin
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 207-222 (2024)
Modulating Tankyrases (TNKS), interactions with USP25 to promote TNKS degradation, rather than inhibiting their enzymatic activities, is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway. Here, we identified UAT-B, a
Externí odkaz:
https://doaj.org/article/17bbbeffc1b74918949ed729dda1f808
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108876- (2024)
Summary: SurE, the first reported penicillin-binding protein-like thioesterase (PBP-like TE), is known as a new off-loading cyclase, which catalyzes heterochiral coupling in nonribosomal peptides (NRPs). However, the structural rationale for substrat
Externí odkaz:
https://doaj.org/article/0cf9d0fe57174cf99e599ac9fd6dd789
Autor:
Ming Yang, Wanlu Li, Lin Zhou, Xiao Lin, Wenyu Zhang, Yaoyao Shen, Hai Deng, Hou-wen Lin, Yongjun Zhou
Publikováno v:
Synthetic and Systems Biotechnology, Vol 8, Iss 3, Pp 349-356 (2023)
The bacterial trialkyl-substituted aromatic polyketides are structurally featured with the unusual aromatic core in the middle of polyketide chain such as TM-123 (1), veramycin A (2), NFAT-133 (3) and benwamycin I (4), which were discovered from Stre
Externí odkaz:
https://doaj.org/article/722f28b8f482441d9ce910a91ba67a3e
Autor:
Xinming Liang, Yaoyao Shen
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-5 (2023)
Abstract Background Glial fibrillary acidic protein (GFAP) astrocytopathy, a novel autoimmune disease of the nervous system, was first defined in 2016. To our knowledge, area postrema syndrome (APS) with linear enhancement along the surface of the br
Externí odkaz:
https://doaj.org/article/820a055dbbae4984830bba9cc8003df5
Publikováno v:
HemaSphere, Vol 7, p e901241f (2023)
Externí odkaz:
https://doaj.org/article/467f91c136e246f2a94bba4668ecc7c2
Publikováno v:
Synthetic and Systems Biotechnology, Vol 7, Iss 3, Pp 880-886 (2022)
Piericidins are a large family of bacterial α-pyridone antibiotics with antitumor activities such as their anti-renal carcinoma activity exhibited recently in nude mice. The backbones of piericidins are derived from β, δ-diketo carboxylic acids, w
Externí odkaz:
https://doaj.org/article/16393221a3af4e78bcadd436cd0d1a1d
Publikováno v:
Bioresources and Bioprocessing, Vol 8, Iss 1, Pp 1-11 (2021)
Abstract Background Neoantimycins are a group of 15-membered ring depsipeptides isolated from Streptomycetes with a broad-spectrum of anticancer activities. Neoantimycin biosynthesis is directed by the hybrid multimodular megaenzymes of non-ribosomal
Externí odkaz:
https://doaj.org/article/cc8c982441dc41f5b17a124dcffcafd7
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-4 (2021)
Abstract Background Currently, myelin oligodendrocyte glycoprotein (MOG)-IgG-associated encephalomyelitis (MOG-EM) is regarded as an independent inflammatory demyelinating disease. Magnetic resonance imaging (MRI) abnormalities occur in 44.4% of pati
Externí odkaz:
https://doaj.org/article/1bbe69f5d31d4ca8a23117bb9712be84
Publikováno v:
BMC Neurology, Vol 20, Iss 1, Pp 1-4 (2020)
Abstract Background Wallerian degeneration (WD) can occur in different projecting systems, such as corticospinal tract, dentate-rubro-olivary pathway, and corticopontocerebellar tract. However, the co-occurrence of hypertrophic olivary degeneration (
Externí odkaz:
https://doaj.org/article/c44e0eb5e87b4c3184dacb156bdfde84