Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Yaoyao Lu"'
Publikováno v:
Fundamental Research, Vol 4, Iss 4, Pp 715-737 (2024)
Drug discovery is costly and time consuming, and modern drug discovery endeavors are progressively reliant on computational methodologies, aiming to mitigate temporal and financial expenditures associated with the process. In particular, the time req
Externí odkaz:
https://doaj.org/article/abe1d527aa9d49e99689609b6ec50f03
Publikováno v:
Schizophrenia Research: Cognition, Vol 36, Iss , Pp 100300- (2024)
Background: Although both anemia and schizophrenia (SCZ) can cause cognitive decline, it is unclear whether anemia worsens cognitive decline in patients with SCZ. The primary objective of this study was to investigate the prevalence of anemia and the
Externí odkaz:
https://doaj.org/article/6d8dbfe1416445deaf3d94e7e3b14802
Publikováno v:
ACS Omega, Vol 9, Iss 1, Pp 1738-1747 (2023)
Externí odkaz:
https://doaj.org/article/33191514eb7140d0b1d10efbf94adee2
Autor:
Eli BenDavid, Sina Ramezanian, Yaoyao Lu, Joël Rousseau, Avi Schroeder, Marc Lavertu, Jacques P. Tremblay
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 763 (2024)
Prime editing shows potential as a precision genome editing technology, as well as the potential to advance the development of next-generation nanomedicine for addressing neurological disorders. However, turning in prime editors (PEs), which are macr
Externí odkaz:
https://doaj.org/article/09d0d33510234dd399a4bb216167add3
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102040- (2023)
Therapeutic genome editing has the potential to cure diseases by directly correcting genetic mutations in tissues and cells. Recent progress in the CRISPR-Cas9 systems has led to breakthroughs in gene editing tools because of its high orthogonality,
Externí odkaz:
https://doaj.org/article/e234a86c012344dfa1a32221c9417299
Publikováno v:
BMC Psychiatry, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Patients with dyslipidemia are at increased risk for suicide, especially those with major depressive disorder (MDD). Few studies have investigated the independent effects of suicide attempts on comorbid dyslipidemia in patients wi
Externí odkaz:
https://doaj.org/article/285541cbe18645c79bba57a13d95e4f3
Autor:
Cedric Happi Mbakam, Joel Rousseau, Yaoyao Lu, Anne Bigot, Kamel Mamchaoui, Vincent Mouly, Jacques P. Tremblay
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 272-285 (2022)
Duchenne muscular dystrophy is a severe debilitating genetic disease caused by different mutations in the DMD gene leading to the absence of dystrophin protein under the sarcolemma. We used CRISPR-Cas9 prime editing technology for correction of the c
Externí odkaz:
https://doaj.org/article/53e3d0650e5c4b7db33a69417ae6c1a1
Autor:
Cedric Happi Mbakam, Jeanne Roustant, Joel Rousseau, Pouire Yameogo, Yaoyao Lu, Anne Bigot, Kamel Mamchaoui, Vincent Mouly, Gabriel Lamothe, Jacques P. Tremblay
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Duchenne muscular dystrophy is a rare and lethal hereditary disease responsible for progressive muscle wasting due to mutations in the DMD gene. We used the CRISPR-Cas9 Prime editing technology to develop different strategies to correct frameshift mu
Externí odkaz:
https://doaj.org/article/a835f08bd75b4b848f7c08256e27f334
Autor:
Jun Yan, Tengsheng Jiang, Junkai Liu, Yaoyao Lu, Shixuan Guan, Haiou Li, Hongjie Wu, Yijie Ding
Publikováno v:
Mathematical Biosciences and Engineering, Vol 19, Iss 8, Pp 7719-7736 (2022)
The study of DNA binding proteins (DBPs) is of great importance in the biomedical field and plays a key role in this field. At present, many researchers are working on the prediction and detection of DBPs. Traditional DBP prediction mainly uses machi
Externí odkaz:
https://doaj.org/article/c2ad5b7c728a48aaa527a93b82e56cf5
Autor:
Yaoyao Lu, Yuna Chai, Jianli Qiu, Jingmin Zhang, Menglin Wu, Zhe Fu, Yongfu Wang, Chongzhen Qin
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and objective: IBS-D is a common functional bowel disease with complex etiology and without biomarker. The pathological and physiological basis of IBS-D focuses on visceral hypersensitivity. However, its epigenetic mechanism remains elusiv
Externí odkaz:
https://doaj.org/article/43392b00f4684e21aa7a73957dd1b3ea