Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yaoqing Diana Liu"'
Autor:
Yaoqing Diana Liu, Gregory C. Flynn
Publikováno v:
Biologicals. 44:163-169
IgG antibodies contain N-linked glycans on the Fc portion of each heavy chain. The glycan on one heavy chain can either match the glycan on the other heavy chain (symmetrical pairing) or be different (asymmetrical pairing). These Fc glycans influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda0229ee3a28da8d0ac315b34a3ecaa
https://doi.org/10.1016/j.biologicals.2016.02.003
https://doi.org/10.1016/j.biologicals.2016.02.003
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 102:519-528
Disulfide reduction in therapeutic monoclonal antibodies can occur during cell harvest operations as a result of cell breakage. Understanding these product quality changes and manufacturers' ability to control them would likely be of concern to regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ef3d8295e9fde21148b486ef104e93
https://doi.org/10.1016/j.jpba.2014.10.023
https://doi.org/10.1016/j.jpba.2014.10.023
Autor:
Yaoqing Diana Liu, Chris Spahr, Leszek Poppe, Gregory C. Flynn, Robert Y.-T. Chou, Stone D.-H. Shi, Thomas M. Dillon
Publikováno v:
Protein Science. 23:1753-1764
Human IgG2 consists of disulfide-mediated structural isoforms, classified by the number of Fab arms disulfide-linked to the heavy chain hinge. In the IgG2-B isoform, both Fab arms are linked to the hinge region, and in IgG2-A, neither Fab arm are lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73fb1dd8cccef952b8c4f2d0196858c0
https://doi.org/10.1002/pro.2557
https://doi.org/10.1002/pro.2557
Autor:
Riki Stevenson, Louise Chen, Gregory C. Flynn, Thomas M. Dillon, Andrew M. Goetze, Gunasekaran Kannan, Xinzhao Grace Jiang, Tian Wang, Gang Huang, Robert Y.-T. Chou, Yaoqing Diana Liu
Publikováno v:
Molecular Immunology. 54:217-226
Human IgG2 antibodies contain three types of disulfide isoforms, classified by the number of Fab arms having disulfide links to the heavy chain hinge region. In the IgG2-B form, both Fab arms have interchain disulfide bonds to the hinge region, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96d8770aa3e5617dbfc94b505c4cc7f
https://doi.org/10.1016/j.molimm.2012.12.005
https://doi.org/10.1016/j.molimm.2012.12.005
Autor:
Gregory C. Flynn, Yaoqing Diana Liu, Jette Wypych, Theresa Martinez, Mei Han, Thomas M. Dillon, Martin J. Allen, Christopher J. Vezina, Alain Balland, Amy Guo, Wenyan D Shen
Publikováno v:
Biochemistry. 48:3755-3766
Human IgG2 exists as a mixture of disulfide-linked structural isoforms that can show different activities. To probe the contribution of specific cysteine residues to the formation of structural isoforms, we characterized a series of Cys-->Ser mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47a4e710ff16421f907836b77233570
https://doi.org/10.1021/bi8022174
https://doi.org/10.1021/bi8022174
Autor:
Thomas M. Dillon, Yaoqing Diana Liu, Matthew H. Plant, Songpon Deechongkit, Yu Li, Chris Vezina, Brad Henkle, Brian Varnum, Gregory C. Flynn, Douglas Rehder, Pavel V. Bondarenko, Margaret Speed Ricci, Jette Wypych, Alain Balland
Publikováno v:
Journal of Biological Chemistry. 283:16206-16215
In the accompanying report ( Wypych, J., Li, M., Guo, A., Zhang, Z., Martinez, T., Allen, M. J., Fodor, S., Kelner, D. N., Flynn, G. C., Liu, Y. D., Bondarenko, P. V., Ricci, M. S., Dillon, T. M., and Balland, A. (2008) J. Biol. Chem. 283, 16194-1620
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5eb3823a1e2bff7b19d433797507bb
https://doi.org/10.1074/jbc.m709988200
https://doi.org/10.1074/jbc.m709988200
Autor:
Tian Wang, Oleg Borisov, Rob Piper, Katariina M. Hutterer, Robert W. Hong, Izydor Apostol, Yaoqing Diana Liu, Rex Pei, Krista Petty, Gregory C. Flynn, M. Eleanor Le, Xiaoyang Zhao, Jonathon Lull
Manufacturing-induced disulfide reduction has recently been reported for monoclonal human immunoglobulin gamma (IgG) antibodies, a widely used modality in the biopharmaceutical industry. This effect has been tied to components of the intracellular th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adf260aa919828875eda012f93d7730
https://europepmc.org/articles/PMC3906314/
https://europepmc.org/articles/PMC3906314/
Autor:
Gregory C. Flynn, Martin J. Allen, Margaret Speed Ricci, Jette Wypych, Pavel V. Bondarenko, Alain Balland, Theresa Martinez, Szilan Fodor, Thomas M. Dillon, Ming Li, Drew N. Kelner, Amy Guo, Yaoqing Diana Liu, Zhongqi Zhang
Publikováno v:
The Journal of biological chemistry. 283(23)
In this work, we present studies of the covalent structure of human IgG2 molecules. Detailed analysis showed that recombinant human IgG2 monoclonal antibody could be partially resolved into structurally distinct forms caused by multiple disulfide bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29a3b9479d41187d63f69456445bf66
https://pubmed.ncbi.nlm.nih.gov/18339624
https://pubmed.ncbi.nlm.nih.gov/18339624
Autor:
Wypych, Jette1 jwypych@amgen.com, Ming Li1, Amy Guo1, Zhongqi Zhang2, Martinez, Theresa1, Allen, Martin J.3, Fodor, Szilan1, Kelner, Drew N.1, Flynn, Gregory C.1, Yaoqing Diana Liu1, Bondarenko, Pavel V.4, Ricci, Margaret Speed4, Dillon, Thomas M.4, Balland, Alain1 ballanda@amgen.com
Publikováno v:
Journal of Biological Chemistry. 6/6/2008, Vol. 283 Issue 23, p16194-16205. 12p. 4 Charts, 11 Graphs.