Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yaolai Wang"'
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
As one of the key proteins, wild-type p53 can inhibit the tumor development and regulate the cell fate. Thus, the study on p53 and its related kinetics has important physiological significance. Previous experiments have shown that wild-type p53-trans
Externí odkaz:
https://doaj.org/article/6946ab32b48642cf81cdd43cd1283860
Publikováno v:
BMC Bioinformatics, Vol 20, Iss S7, Pp 83-96 (2019)
Abstract Background Lung adenocarcinoma is the most common type of lung cancer, with high mortality worldwide. Its occurrence and development were thoroughly studied by high-throughput expression microarray, which produced abundant data on gene expre
Externí odkaz:
https://doaj.org/article/d10bf99500ee46bd84f9eec7a1025f41
Publikováno v:
Biology, Vol 9, Iss 10, p 339 (2020)
Gene transcription has been uncovered to occur in sporadic bursts. However, due to technical difficulties in differentiating individual transcription initiation events, it remains debated as to whether the burst size, frequency, or both are subject t
Externí odkaz:
https://doaj.org/article/f04d7ff0f2e844cebdf613276b31a015
Publikováno v:
Interdisciplinary Sciences: Computational Life Sciences. 12:226-236
Hepatocellular carcinoma (HCC) is a common cancer of high mortality, mainly due to the difficulty in diagnosis during its clinical stage. Here we aim to find the gene biomarkers, which are of important significance for diagnosis and treatment. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9c6f0c6ebdec63f3188bb3b9ddc2eb
https://doi.org/10.1007/s12539-020-00366-8
https://doi.org/10.1007/s12539-020-00366-8
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 20, Iss S7, Pp 83-96 (2019)
BMC Bioinformatics, Vol 20, Iss S7, Pp 83-96 (2019)
Background Lung adenocarcinoma is the most common type of lung cancer, with high mortality worldwide. Its occurrence and development were thoroughly studied by high-throughput expression microarray, which produced abundant data on gene expression, DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dbcd757d672da0fc346964430d899f
http://europepmc.org/articles/PMC6509866
http://europepmc.org/articles/PMC6509866
Publikováno v:
Biology
Volume 9
Issue 10
Biology, Vol 9, Iss 339, p 339 (2020)
Volume 9
Issue 10
Biology, Vol 9, Iss 339, p 339 (2020)
Simple Summary Following changing cellular signals, various genes adjust their activities and initiate transcripts with the right rates. The precision of such a transcriptional response has a fundamental role in the survival and development of lives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e84a4e22b2e531e6dd1b39627e9eca
https://doi.org/10.3390/biology9100339
https://doi.org/10.3390/biology9100339
Publikováno v:
Biological Reviews of the Cambridge Philosophical Society
There is accumulating evidence that, from bacteria to mammalian cells, messenger RNAs (mRNAs) are produced in intermittent bursts – a much ‘noisier’ process than traditionally thought. Based on quantitative measurements at individual promoters,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ed653162f9d50b2bc7c25e4228121bb
https://pubmed.ncbi.nlm.nih.gov/30024089
https://pubmed.ncbi.nlm.nih.gov/30024089
Publikováno v:
Nucleic Acids Research
Transcription initiation is orchestrated by dynamic molecular interactions, with kinetic steps difficult to detect. Utilizing a hybrid method, we aim to unravel essential kinetic steps of transcriptional regulation on the glnAp2 promoter, whose regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94439d8d60a94a4f595d12636403f120
https://pubmed.ncbi.nlm.nih.gov/27899598
https://pubmed.ncbi.nlm.nih.gov/27899598
Publikováno v:
Scientific Reports
The transcription apparatus (TA) is a huge molecular machine. It detects the time-varying concentrations of transcriptional activators and initiates mRNA transcripts at appropriate rates. Based on the general structural organizations of the TA, we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7363f19398d0819aa8291d8add7d1b
https://doi.org/10.1038/srep00422
https://doi.org/10.1038/srep00422
Publikováno v:
Journal of The Royal Society Interface. 11:20140253
During gene transcription, proteins appear to cycle on and off some gene promoters with both long (tens of minutes) and short periods (no more than several minutes). The essence of these phenomena still remains unclear. Here, we propose a stochastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2851caa52885c937fcde46e63115a18
https://doi.org/10.1098/rsif.2014.0253
https://doi.org/10.1098/rsif.2014.0253