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Akademický článek

Epidemiological changes of scarlet fever before, during and after the COVID-19 pandemic in Chongqing, China: a 19-year surveillance and prediction study

Autor: Rui Wu, Yu Xiong, Ju Wang, Baisong Li, Lin Yang, Han Zhao, Jule Yang, Tao Yin, Jun Sun, Li Qi, Jiang Long, Qin Li, Xiaoni Zhong, Wenge Tang, Yaokai Chen, Kun Su

Publikováno v: BMC Public Health, Vol 24, Iss 1, Pp 1-11 (2024)

Abstract Background This study aimed to investigate the epidemiological changes in scarlet fever before, during and after the COVID-19 pandemic (2005–2023) and predict the incidence of the disease in 2024 and 2025 in Chongqing Municipality, Southwe

Externí odkaz: https://doaj.org/article/027e19852ea949fba864e3854085c007

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Akademický článek

Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma

Autor: Jia Yang, Xiaoni Zhong, Xiaoling Gao, Wenyi Xie, Yaokai Chen, Yuanjiang Liao, Peilin Zhang

Publikováno v: Cell Adhesion & Migration, Vol 18, Iss 1, Pp 1-12 (2024)

In this research, we investigated the role of PIK3R6, a regulatory subunit of PI3Kγ, known for its tumor-promoting properties, in clear cell renal cell carcinoma (CCRCC). Utilizing the UALCAN website, we found PIK3R6 upregulated in CCRCC, correlatin

Externí odkaz: https://doaj.org/article/284ac985eee94b929a62c80fd646c616

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Akademický článek

Intestinal barrier damage contributes to a higher prevalence of frailty in aging people living with HIV: a retrospective case control study in a Chinese cohort

Autor: Xiaolei Xu, Jing Ouyang, Jiangyu Yan, Yanqiu Lu, Vijay Harypursat, Hao Wu, Yaokai Chen

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundIt has been previously demonstrated that intestinal barrier damage is one of the underlying mechanisms leading to frailty in non-HIV-infected aging populations. However, there is a paucity of direct evidence which demonstrates the associati

Externí odkaz: https://doaj.org/article/381d5268a10c4660bda5e4cd2c319550

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Akademický článek

Mechanisms underlying the development of type 1 diabetes in ART-treated people living with HIV: an enigmatic puzzle

Autor: Silvere D. Zaongo, Abel W. Zongo, Yaokai Chen

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM)

Externí odkaz: https://doaj.org/article/9fa7fabc15b846bc946c3718456235b6

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Akademický článek

Performance of metagenomic Next-Generation Sequencing and metagenomic Nanopore Sequencing for the diagnosis of tuberculosis in HIV-positive patients

Autor: Jing Yuan, Lanchun Wang, Wei Zhang, Changgang Deng, Qisui Li, Yamin Meng, Yaokai Chen

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

BackgroundPatients who were infected by the Human Immunodeficiency Virus (HIV) could have weakened immunity that is complicated by opportunistic infections, especially for Mycobacterium tuberculosis (MTB). Notably, the HIV-MTB co-infection will accel

Externí odkaz: https://doaj.org/article/f73177ffabe144fd9d6e07e8ea26d048

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Akademický článek

Interactions between HIV proteins and host restriction factors: implications for potential therapeutic intervention in HIV infection

Autor: Farooq Rashid, Silvere D. Zaongo, Hifza Iqbal, Vijay Harypursat, Fangzhou Song, Yaokai Chen

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Different host proteins target different HIV proteins and antagonize their functions, depending on the stage of the HIV life cycle and the stage of infection. Concurrently, HIV proteins also target and antagonize various different host proteins to fa

Externí odkaz: https://doaj.org/article/a4cad7f2411d42699f7c444da7b5dd6f

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Akademický článek

Delving deeper into the mechanisms fundamental to HIV-associated immunopathology using single-cell sequencing techniques: A scoping review of current literature

Autor: Ting Zhao, Yixian Jing, Yao Li, Yinqiu Huang, Yanqiu Lu, Yaokai Chen

Publikováno v: Heliyon, Vol 10, Iss 16, Pp e35856- (2024)

Human immunodeficiency virus (HIV) infection has evolved into an established global pandemic over the past four decades; however, despite massive research investment globally, the precise underlying mechanisms which are fundamental to HIV-related pat

Externí odkaz: https://doaj.org/article/f02e6487c05b441b8a00be989f743b99

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Akademický článek

HIV-associated neurocognitive disorder: key implications of the microbiota-gut-brain axis

Autor: Aizhen Hu, Silvere D. Zaongo, Vijay Harypursat, Xin Wang, Jing Ouyang, Yaokai Chen

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

HIV-associated neurocognitive disorder (HAND) is now recognized to be relatively common in people living with HIV (PLWH), and remains a common cause of cognitive impairment. Unfortunately, the fundamental pathogenic processes underlying this specific

Externí odkaz: https://doaj.org/article/28fec58af651490dbc908a3b5dc0c4fc

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Akademický článek

Switch to fixed-dose ainuovirine, lamivudine, and tenofovir DF versus elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in virologically suppressed people living with HIV-1: the 48-week results of the SPRINT trial, a multi-centre, randomised, double-blind, active-controlled, phase 3, non-inferiority trialResearch in context

Autor: Fujie Zhang, Hao Wu, Weiping Cai, Ping Ma, Qingxia Zhao, Hongxia Wei, Hongzhou Lu, Hui Wang, Shenghua He, Zhu Chen, Yaokai Chen, Min Wang, Wan Wan, Heliang Fu, Hong Qin

Publikováno v: The Lancet Regional Health. Western Pacific, Vol 49, Iss , Pp 101143- (2024)

Summary: Background: We compared the efficacy and safety profiles of ainuovirine (ANV), a new-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), with boosted elvitegravir (EVG), both coformulated with two nucleoside reverse transcript

Externí odkaz: https://doaj.org/article/4a3e045056b747ab837abc93ba3827f6

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Akademický článek

Prevalence and antimicrobial susceptibility pattern of Mycobacterium abscessus complex isolates in Chongqing, Southwest China

Autor: Yan Hu, Tongxin Li, Wenguo Liu, Damian Zhu, Xin Feng, Yaokai Chen, Huiwen Zheng

Publikováno v: Heliyon, Vol 10, Iss 14, Pp e34546- (2024)

Objectives: To investigate the prevalence of Mycobacterium abscessus complex (MABC), drug resistance characteristics, and the relationship between clarithromycin (CLA) susceptibility and MABC genotype in Chongqing, China. Methods: A total of 434 NTM

Externí odkaz: https://doaj.org/article/6915324e600b4f9dbdc63edcf1c4538e

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