Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Yao-xue Guo"'
Publikováno v:
Xenobiotica. 47:154-163
Combination of isoniazid (INH) and rifampicin (RFP) causes liver injury frequently among tuberculosis patients. However, mechanisms of the hepatotoxicity are not entirely understood. Protoporphyrin IX (PPIX) accumulation, as an endogenous hepatotoxin
Autor:
Zhi-Rong Tan, Ye Chen, Yao-xue Guo, Weidong Zhang, Wei-Hua Huang, Yicheng Wang, Xiu-Xian Lin, Jingbo Peng, Dong-Li Hu, Dan Chen
Publikováno v:
Xenobiotica. 46:1085-1092
1.Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA, a famous Chinese medicine used for many years to treat cardiovascular disorders. However, the role of cytochrome P450 (CYP) enzymes in the metabolism of STS was
Autor:
Qi Zhi Zhang, Wen Xing Peng, Ye Deng, Lei Yan He, Yao Xue Guo, Xue Fei Xu, Chun Li, Pei Jiang
Publikováno v:
Toxicology mechanisms and methods. 25(5)
Co-treatment of isoniazid (INH) and rifampicin (RFP) is well known for clinically apparent liver injury. However, the mechanism of INH/RFP-induced liver injury is controversial. Emerging evidence shows links between inhibition of bile acids transport