Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yao-Zhong Lin"'
Autor:
Weiyue Lu, Yang Hu, Xiaoyi Wang, Shengyu Yao, Kuan Jiang, Yanyu Zhang, Yu Liu, Gang Wei, Yao-Zhong Lin, Huan Wang
Publikováno v:
Molecular Pharmaceutics. 17:3685-3695
Current chemotherapy for lung cancer achieved limited efficacy due to poor tumor targeting and tissue penetration. Another obstacle in the therapy is activated nuclear factor-κB (NF-κB) in tumor cells, which plays a crucial role in promotion of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77de918c98ffd1a14084a64ea1163326
https://doi.org/10.1021/acs.molpharmaceut.0c00052
https://doi.org/10.1021/acs.molpharmaceut.0c00052
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 289
Application of liposomes-based drug delivery in treatment of glioma has been hampered by the poor permeability of blood-brain barrier and the low uptake efficiency by glioma tissues. Moreover, many chemotherapy drugs promote the activation of the NF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e2648b9038226dc454d0a7cfb52ae9
https://pubmed.ncbi.nlm.nih.gov/30243823
https://pubmed.ncbi.nlm.nih.gov/30243823
Autor:
Gang Wei, Weiyue Lu, Li Zhang, Zhuoquan Li, Kuan Jiang, Lingyu Tai, Weisan Pan, Yao-Zhong Lin, Yanyu Zhang, Cao Xie
Publikováno v:
Acta biomaterialia. 42
Clinical application of cell-penetrating peptides (CPPs) in cancer therapy is greatly restricted due to lack of tissue selectivity and tumor-targeting ability. CB5005, a rationally designed CPP that targets and inhibits intracellular NF-κB activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee51461d36497f5e3b45626fe14efeb
https://pubmed.ncbi.nlm.nih.gov/27370905
https://pubmed.ncbi.nlm.nih.gov/27370905
Publikováno v:
The Journal of Peptide Research. 51:235-243
Cell-permeable peptide import recently was developed to deliver synthetic peptides into living cells for studying intracellular protein functions. This import process is mediated by an N-terminal carrier sequence which is the hydrophobic region of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955aa06c8d8ad63f5a676aee1ede430b
https://doi.org/10.1111/j.1399-3011.1998.tb01221.x
https://doi.org/10.1111/j.1399-3011.1998.tb01221.x
Publikováno v:
The Journal of Immunology. 161:6084-6092
Activation of T lymphocytes by Ags or cytokines results in translocation of the transcription factors NF-κB, AP-1, NFAT, and STAT from the cytoplasm into the nucleus. The first step in the nuclear import process is recognition of a nuclear localizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::691863a0b3b87f9d502983b63fbe8a1c
https://doi.org/10.4049/jimmunol.161.11.6084
https://doi.org/10.4049/jimmunol.161.11.6084
Publikováno v:
Nature Biotechnology. 16:370-375
The discovery of methods for generating proteins with inherent cell membrane-translocating activity will expand our ability to study and manipulate various intracellular processes in living systems. We report a method to engineer proteins with cell-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::149459167e8e74b498a14b4084513c04
https://doi.org/10.1038/nbt0498-370
https://doi.org/10.1038/nbt0498-370
Publikováno v:
Journal of Biological Chemistry. 271:27456-27461
Epidermal growth factor (EGF)-stimulated Ras activation involves specific interactions between the EGF receptor (EGFR), the adaptor proteins Grb2 and Shc, and the nucleotide exchange factor Sos-1. Study and control of these protein-protein interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba0390bf02deabf27819db72d7097d3
https://doi.org/10.1074/jbc.271.44.27456
https://doi.org/10.1074/jbc.271.44.27456
Publikováno v:
Journal of Biological Chemistry. 270:14255-14258
To control agonist-induced nuclear translocation of transcription factor kappa B (NF-kappa B) in intact cells, cell-permeable synthetic peptides were devised. Their import into intact cells was dependent on a hydrophobic region selected from the sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec40103133a335755ad2332543b177a
https://doi.org/10.1074/jbc.270.24.14255
https://doi.org/10.1074/jbc.270.24.14255
Publikováno v:
Biochemistry. 30:3310-3314
Myxoma virus growth factor (MGF) is an 85-residue peptide derived from the gene product of a DNA tumor virus that infects rabbits. The carboxyl domain of MGF possesses about 40% sequence homology with the epidermal growth factor (EGF). This EGF-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b76684de20cea5437b95627bc8b65f8
https://doi.org/10.1021/bi00227a020
https://doi.org/10.1021/bi00227a020
Publikováno v:
The Journal of Organic Chemistry. 55:251-259
Deux groupes protecteurs: le chloro-2 indenyl-3 methoxycarbonyl et le benzo [f] indenyl-1 methoxycarbonyl peuvent etre utilises lors de synthese de Merrifield; l'assemblage d'oligopeptides non automatise est possible par l'utilisation en tandem de 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa772d8c2460744307d38fb129fb8cd5
https://doi.org/10.1021/jo00288a042
https://doi.org/10.1021/jo00288a042