Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Yao-Yun Fan"'
Autor:
Yao-Yun Fan, Vahid Farrokhi, Teresa Caiazzo, Mengmeng Wang, Denise M. O’Hara, Hendrik Neubert
Publikováno v:
Biomolecules, Vol 9, Iss 8, p 373 (2019)
System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically-
Externí odkaz:
https://doaj.org/article/dcd48019d69f4027b5e73268d3404310
Autor:
Yao-Yun Fan, 范耀云
94
Tumor associated antigens arising from aberrant glycosylation is a well recognized phenomenon in cancer biology. Among the more notable structural features is the rare occurrence of extended type 1 chain on the lactosylceramides of the human
Tumor associated antigens arising from aberrant glycosylation is a well recognized phenomenon in cancer biology. Among the more notable structural features is the rare occurrence of extended type 1 chain on the lactosylceramides of the human
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/61229175259005862020
Publikováno v:
Biomolecules, Vol 9, Iss 8, p 373 (2019)
Biomolecules
Biomolecules
System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80abf937dcc2c29fd7d026917be8ae1d
https://www.mdpi.com/2218-273X/9/8/373
https://www.mdpi.com/2218-273X/9/8/373
Publikováno v:
Bioanalysis. 8:1551-1555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b003aac1c9d13ab3f32752d561122b9
https://doi.org/10.4155/bio-2016-0155
https://doi.org/10.4155/bio-2016-0155
Publikováno v:
mAbs. 8:848-853
The neonatal Fc receptor (FcRn) is a homeostatic receptor responsible for prolonging immunoglobulin G (IgG) half-life by protecting it from lysosomal degradation and recycling it to systemic circulation. Tissue-specific FcRn expression is a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1220a8956e46f21cc60e85083d27fe7d
https://doi.org/10.1080/19420862.2016.1178436
https://doi.org/10.1080/19420862.2016.1178436
Autor:
Aili Cheng, Robert J Polzer, Fei Hua, Martin E. Dowty, Lindsay B. Avery, Hannah M. Jones, Alison Joyce, Yiqun Zhang, Hendrik Neubert, Mania Kavosi, Yao-Yun Fan, Minlei Zhang, Mengmeng Wang, Jeffrey C Kurz, Denise O'Hara
Publikováno v:
mAbs. 8(6)
Therapeutic antibodies continue to develop as an emerging drug class, with a need for preclinical tools to better predict in vivo characteristics. Transgenic mice expressing human neonatal Fc receptor (hFcRn) have potential as a preclinical pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f9d287258f7be2850dbc301f241795
https://pubmed.ncbi.nlm.nih.gov/27232760
https://pubmed.ncbi.nlm.nih.gov/27232760
Autor:
Yao-Yun Fan, Hendrik Neubert
Publikováno v:
Analytical chemistry. 88(8)
Neonatal Fc receptor (FcRn) is the homeostatic receptor responsible for the long half-life of endogenous IgG by protecting it from lysosomal degradation. Understanding systemic FcRn tissue expression is important to predict and design the half-life o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7730116d9d6e66f67088c58cbe75a82a
https://pubmed.ncbi.nlm.nih.gov/27012525
https://pubmed.ncbi.nlm.nih.gov/27012525
Autor:
Lamia Laacisse, Markus Aebi, Carolina Fontana, Göran Widmalm, Yao-Yun Fan, Salomé LeibundGut-Landmann, Manuela Mally
Publikováno v:
Molecular Microbiology. 87:112-131
Bacterial carbohydrate structures play a central role in mediating a variety of host-pathogen interactions. Glycans can either elicit protective immune response or lead to escape of immune surveill ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6d4b44cd086aaf5d6b877dd022a78e
https://doi.org/10.1111/mmi.12086
https://doi.org/10.1111/mmi.12086
Publikováno v:
The Journal of biological chemistry
N-Linked glycosylation is a frequent protein modification that occurs in all three domains of life. This process involves the transfer of a preassembled oligosaccharide from a lipid donor to asparagine side chains of polypeptides and is catalyzed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3710de635d6124c18dd8315b54d0cd7f
https://doi.org/10.1074/jbc.m111.277160
https://doi.org/10.1074/jbc.m111.277160
Publikováno v:
Bioconjugate chemistry
Glycosylation is the predominant protein modification to diversify the functionality of proteins. In particular, N-linked protein glycosylation can increase the biophysical and pharmacokinetic properties of therapeutic proteins. However, the major ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64225a7d29e9eec45703ee9968d0d5a2
https://doi.org/10.1021/bc100511k
https://doi.org/10.1021/bc100511k