Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Yao-Rong Zheng"'
Autor:
Wjdan Jogadi, Man B. Kshetri, Suha Alqarni, Arpit Sharma, May Cheline, Md Al Amin, Cynthia Sheets, Angele Nsoure-Engohang, Yao-Rong Zheng
Publikováno v:
Molecules, Vol 29, Iss 17, p 4095 (2024)
In this study, we report a novel platinum–doxorubicin conjugate that demonstrates superior therapeutic indices to cisplatin, doxorubicin, or their combination, which are commonly used in cancer treatment. This new molecular structure (1) was formed
Externí odkaz:
https://doaj.org/article/0e2c7550300e411da9f83e27f3ba246b
Autor:
Nalin Abeydeera, Morgan Stilgenbauer, Bishnu D. Pant, Khalil Mudarmah, Thiloka M. Dassanayake, Yao-Rong Zheng, Songping D. Huang
Publikováno v:
Molecules, Vol 28, Iss 13, p 4917 (2023)
Although iron is essential for all forms of life, it is also potentially toxic to cells as the increased and unregulated iron uptake can catalyze the Fenton reaction to produce reactive oxygen species (ROS), leading to lipid peroxidation of membranes
Externí odkaz:
https://doaj.org/article/c1b1197051d04c0db9e83aff4cf15ffc
Autor:
Han Wang, Zihan Qiu, He Liu, Amarasooriya M. D. S. Jayawardhana, Zhizhou Yue, Hala Daghlas, David J. Bowers, Bansidhar Datta, Yao-Rong Zheng
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
A long-standing challenge in the treatment of ovarian cancer is drug resistance to standard platinum-based chemotherapy. Recently, increasing attention has been drawn to the use of self-assembled metal-organic complexes as novel therapeutics for canc
Externí odkaz:
https://doaj.org/article/c066d7bc865e4d5993f2d5c3bfffe3b1
Autor:
Huang, Nalin Abeydeera, Morgan Stilgenbauer, Bishnu D. Pant, Khalil Mudarmah, Thiloka M. Dassanayake, Yao-Rong Zheng, Songping D.
Publikováno v:
Molecules; Volume 28; Issue 13; Pages: 4917
Although iron is essential for all forms of life, it is also potentially toxic to cells as the increased and unregulated iron uptake can catalyze the Fenton reaction to produce reactive oxygen species (ROS), leading to lipid peroxidation of membranes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::d7bc89c593f594e9b65b59026983ed07
Publikováno v:
Dalton Trans
In this work, we present the first study about the interactions of mitochondria-damaging Pt(iv) prodrugs with cytochrome c. We synthesized a cisplatin-based Pt(iv) prodrug bearing a lipophilic hydrocarbon tail and anionic dansyl head group. The amphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d2f3f9380c882a7eb13e966c500f1d
https://doi.org/10.1039/d1dt03875c
https://doi.org/10.1039/d1dt03875c
Autor:
Wjdan Jogadi, Yao-Rong Zheng
Publikováno v:
Current Opinion in Chemical Biology. 73:102276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebac289cdb12b0f395aea116f125508b
https://doi.org/10.1016/j.cbpa.2023.102276
https://doi.org/10.1016/j.cbpa.2023.102276
Autor:
Zhizhou Yue, Payel Datta, Yao-Rong Zheng, Han Wang, Manabu Kurokawa, Morgan Stilgenbauer, Scott Bang, Travis Beach, Haihua Xiao, David J. Bowers
Publikováno v:
Dalton Transactions. 49:8107-8113
Cisplatin is a platinum-based chemotherapeutic agent widely used in the treatment of various solid tumors. However, a major challenge in the use of cisplatin and in the development of cisplatin derivatives, namely Pt(iv) prodrugs, is their premature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c0688555a35c5ee66a9206255be01c
https://doi.org/10.1039/d0dt01297a
https://doi.org/10.1039/d0dt01297a
Autor:
Bin Huang, Issiah B. Lozada, David E. Herbert, Yao-Rong Zheng, Travis Beach, Morgan Stilgenbauer, Zihan Qiu
Publikováno v:
Dalton Transactions. 49:6557-6560
Phenanthriplatin is a leading preclinical anticancer Pt complex distinguished by a phenanthridine ligand that facilitates DNA-targeted covalent binding via intercalation. We report here that Pt(ii) complexes incorporating phenanthridine into a chelat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728e49382f061ffdce4bda4efd29dfa1
https://doi.org/10.1039/d0dt01275k
https://doi.org/10.1039/d0dt01275k
Autor:
Zhihan Qiu, David J. Bowers, Amarasooriya M. D. S. Jayawardhana, Han Wang, Susan Kempf, Yao-Rong Zheng, Mitchell Miterko
Publikováno v:
Dalton Transactions. 48:12451-12458
Drug resistance to the conventional platinum chemotherapy remains a major challenge for treating ovarian cancer. Herein, we present a novel approach to overcome the drug resistance by utilizing “dual-action” organometallic polymeric nanoparticles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60455321da6559b956fc8dc10ae338bb
https://doi.org/10.1039/c9dt01683j
https://doi.org/10.1039/c9dt01683j
Autor:
Sagun Jonchhe, Deepak Karna, Kazuya Ankai, Yao-Rong Zheng, Yuki Suzuki, Morgan Stilgenbauer, Hanbin Mao, Yunxi Cui, Ibuki Kawamata
Publikováno v:
Bioconjug Chem
Cell motions such as migration and change in cellular morphology are essential activities for multicellular organism in response to environmental stimuli. These activities are a result of coordinated clustering/declustering of integrin molecules at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156014215cd260b6dd86e6d2d1383523
https://pubmed.ncbi.nlm.nih.gov/33475341
https://pubmed.ncbi.nlm.nih.gov/33475341