Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Yao-Jun Shi"'
Autor:
Yao Jun Shi, Nai Qun Wu
Publikováno v:
Advanced Materials Research. :134-137
With the rapid development of economic and cultural , many cities have built their new areas, the citiesbecom larger and larger, people enjoy the high quality life brought by the rapid development of the citis, at the same time, the lager cities also
Publikováno v:
Transactions of Nonferrous Metals Society of China. 22:654-660
The first-principle calculations were performed to investigate the structural, mechanical, electronic and thermal properties of the binary ductile intermetallic compound CeAg with B2 (CsCl) structure. The calculated value of lattice constant a0 for C
Publikováno v:
The Journal of Organic Chemistry. 72:7447-7450
Thiazolyl peptide antibiotic nocathiacin I (1) was converted to nocathiacin acid (4) in high yield by treatment with trifluoroacetic anhydride and pyridine in THF at room temperature. Two equipotent water-soluble amide analogues of nocathiacin I were
Publikováno v:
Organic Process Research & Development. 10:398-402
An expedient regioselective synthesis of a GABA α2/3 agonist 1 is described. The key step is an efficient regioselective palladium-catalyzed coupling of 7-trifluoromethylimidazo[1,2-a]pyrimidine (5) to 5‘-chloro-4,2‘-difluorobiphenyl-2-carbonitr
Autor:
Ulf-H. Dolling, Brenda Pipik, Yao-Jun Shi, James M. McNamara, George Zhou, Cameron J. Cowden, David A. Conlon, F. Conrad Engelhardt
Publikováno v:
The Journal of Organic Chemistry. 71:480-491
[reaction: see text] A newly developed synthesis of a NO-releasing prodrug of rofecoxib is described. The highly productive process consists of five chemical steps and produces prodrug 1 in an overall 64% yield from commercially available 3-phenyl-2-
Autor:
Dwight Macdonald, Antoinette Drahus-Paone, Roy Helmy, Denis Deschenes, Guo-Jie Ho, John Scheigetz, James M. McNamara, Brenda Pipik, Yao-Jun Shi, David A. Conlon, Michel Gallant, Bruno Roy, J. Michael Williams, Anthony Mastracchio
Publikováno v:
Organic Process Research & Development. 10:36-45
An efficient, scalable synthesis of the PDE4 inhibitor, 6-[1-methyl-1-(methylsulfonyl)ethyl]-8-(3-{(E)-2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-[4-(methylsulfonyl)phenyl]vinyl}phenyl)quinoline benzenesu...
Autor:
J. Michael Williams, Guo‐Jie Ho, David A. Conlon, Carl LeBlond, Simone Ferdinand, Bill Izzo, John R. Sowa, Brenda Pipik, Yao-Jun Shi, Yongkui Sun, Paul Collins
Publikováno v:
Advanced Synthesis & Catalysis. 345:931-935
The Suzuki–Miyaura cross-coupling reaction using heterogeneous Pd/C has a homogeneous component. The soluble palladium concentration increases during the reaction reaching a maximum at ca. 90% conversion before falling to
Autor:
Michael B. Hicks, Vincent Antonucci, George Zhou, Joseph E. Lynch, Mark Cameron, Yao-Jun Shi, David R. Lieberman, Zhihong Ge
Publikováno v:
Journal of Pharmaceutical Sciences. 92:529-535
A simple and safe prototype apparatus was designed and adapted for the in situ determination of the moisture content of a cytotoxic compound (9-fluorenylmethyl-protected doxorubicin-peptide conjugate, or Fm-DPC) by near-infrared absorbance spectrosco
Autor:
Mark Cameron, Yao-Jun Shi, Paul J. Reider, Robert A. Reamer, Michael A. Robbins, Joseph E. Lynch, David R. Lieberman, Ralph P. Volante, Ulf H. Dolling
Publikováno v:
Synlett. :0647-0650
An efficient synthesis of the sodium salt of the doxorubicin-peptide conjugate 1, useful for the treatment of prostate cancer is described. The EDC-mediated amide formation between the heptapeptide 4 and doxorubicin (2) as the key step has been exten
Autor:
George Zhou, Zhihong Ge, Vincent Antonucci, Yao-Jun Shi, Mark Cameron, David R. Lieberman, Micheal B Hicks, Joesph E Lynch
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 28:137-144
A method for accurately determining the end-point,98% conversion, of the deprotection reaction of a highly toxic 9-fluorenylmethyl (Fm) ester 1b to its corresponding carboxylate 1d in real time by FT-IR spectroscopy is reported. Advantages of this me