Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yao-Chang Tsan"'
Autor:
Elizabeth A. Werren, Emily R. Peirent, Henna Jantti, Alba Guxholli, Kinshuk Raj Srivastava, Naama Orenstein, Vinodh Narayanan, Wojciech Wiszniewski, Mateusz Dawidziuk, Pawel Gawlinski, Muhammad Umair, Amjad Khan, Shahid Niaz Khan, David Geneviève, Daphné Lehalle, K. L. I. van Gassen, Jacques C. Giltay, Renske Oegema, Richard H. van Jaarsveld, Rafiullah Rafiullah, Gudrun A. Rappold, Rachel Rabin, John G. Pappas, Marsha M. Wheeler, Michael J. Bamshad, Yao-Chang Tsan, Matthew B. Johnson, Catherine E. Keegan, Anshika Srivastava, Stephanie L. Bielas
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-15 (2024)
Abstract CSMD1 (Cub and Sushi Multiple Domains 1) is a well-recognized regulator of the complement cascade, an important component of the innate immune response. CSMD1 is highly expressed in the central nervous system (CNS) where emergent functions o
Externí odkaz:
https://doaj.org/article/08dbba4aad0f4fdba2b94ba2c9076513
Autor:
Yao-Chang Tsan, Samuel J. DePalma, Yan-Ting Zhao, Adela Capilnasiu, Yu-Wei Wu, Brynn Elder, Isabella Panse, Kathryn Ufford, Daniel L. Matera, Sabrina Friedline, Thomas S. O’Leary, Nadab Wubshet, Kenneth K. Y. Ho, Michael J. Previs, David Nordsletten, Lori L. Isom, Brendon M. Baker, Allen P. Liu, Adam S. Helms
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Investigations of human cardiac disease involving human pluripotent stem cell-derived cardiomyocytes are limited by the disorganized presentation of biomechanical cues resulting in cell immaturity. Here the authors develop a platform of micron-scale
Externí odkaz:
https://doaj.org/article/866175855d3a4449bdab9d5e10355c8b
Publikováno v:
Stem Cell Research, Vol 17, Iss 2, Pp 238-247 (2016)
Over-expression of the early neural inducer, Noggin, in nestin positive subventricular zone (SVZ), neural stem cells (NSC) promotes proliferation and neuronal differentiation of neural progenitors and inhibits the expression of a CNS-enriched microRN
Externí odkaz:
https://doaj.org/article/cdb20bf75617461a8779a4fbd68da584
Publikováno v:
Stem Cell Research, Vol 14, Iss 1, Pp 79-94 (2015)
Multipotent, self-renewing stem cells are present throughout the developing nervous system remaining in discrete regions of the adult brain. In the subventricular zone (SVZ) signaling molecules, including the bone morphogenetic proteins and their sec
Externí odkaz:
https://doaj.org/article/902577f559494c999984398d9d147cae
Autor:
Vi T. Tang, Kathryn Ufford, Zhaowen Tong, Allen P. Liu, Sabrina Friedline, Stephanie L. Bielas, Adam S. Helms, Amani S. Dobbs, Yao-Chang Tsan
Publikováno v:
Stem Cell Reports
Summary Disease modeling and pharmaceutical testing using cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) requires accurate assessment of contractile function. Micropatterning iPSC-CMs on elastic substrates controls cell shape a
Autor:
Eric Smith, Brynn Elder, Gabriela Chen, Yao-chang Tsan, John Stendahl, Jodie Ingles, Victoria N Parikh, Samuel Wittekind, Steven Colan, Neal K Lakdawala, Anjali T Owens, Daniel L Jacoby, Sharlene Day, Christopher Semsarian, iacopo olivotto, Carolyn Ho, Mark W Russell, Sara Saberi, James S Ware, Adam S Helms
Publikováno v:
Circulation. 144
Introduction: Genetic hypertrophic cardiomyopathy (HCM) is an autosomal dominant inherited condition primarily due to pathogenic variants in sarcomere genes, often with marked clinical variability. We hypothesized that this variability may, in part,
Autor:
Daniel L. Matera, Thomas S. O’Leary, Yu-Wei Wu, Nadab Wubshet, Brendon M. Baker, David Nordsletten, Yao-Chang Tsan, Yan-Ting Zhao, Brynn Elder, Kathryn Ufford, Adela Capilnasiu, Kenneth K. Y. Ho, Isabella Panse, Lori L. Isom, Sabrina Friedline, Adam S. Helms, Michael J. Previs, Samuel J. DePalma, Allen P. Liu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) allow investigations in a human cardiac model system, but disorganized mechanics and immaturity of hPSC-CMs on standard two-dimensional surfaces have been hurdles. Here, we developed a pla
Autor:
Jiaqiang Zhu, Stephanie L. Bielas, Yao-Chang Tsan, BT McGrath, S Salvi, N Girgla, Anshika Srivastava, Amanda Moccia, P Wu, R Kc, Xiao-Gen Zhou, Xiaoyun Chen
During corticogenesis, transcription plasticity is fundamental to the restriction of neural progenitor cell (NPC) multipotency and production of cortical neuron heterogeneity. Human and mouse genetic studies have highlighted the role of Polycomb tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b63728928206c0778b337473537c4b
https://doi.org/10.1101/2021.07.20.452995
https://doi.org/10.1101/2021.07.20.452995
Autor:
Isabella Panse, Nadab Wubshet, Lori L. Isom, Adela Capilnasiu, Yao-Chang Tsan, Kenneth K. Y. Ho, Brendon M. Baker, David Nordsletten, Adam S. Helms, Sabrina Friedline, Brynn Elder, Yan-Ting Zhao, Thomas S. O’Leary, Michael J. Previs, Yu Wei Wu, Samuel J. DePalma, Allen P. Liu
Human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) allow novel investigations of human cardiac disease, but disorganized mechanics and immaturity of hPSC-CMs on two-dimensional (2D) surfaces have been hurdles for efficient and reproducible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aefb37cf4b19c455decfc4dbb9e0826e
https://doi.org/10.1101/2021.05.23.445330
https://doi.org/10.1101/2021.05.23.445330
Autor:
Chunaram Choudhary, Benjamin A. Garcia, Thomas L. Saunders, Le Tran Phuc Khoa, Natarajan V. Bhanu, Fengbiao Mao, Li Zhang, Xin Tong, Yao-Chang Tsan, Stephanie L. Bielas, Daniel M. Kremer, Peter Sajjakulnukit, Lei Yin, Gary D. Smith, Costas A. Lyssiotis, Bo Zhou, Yali Dou
Publikováno v:
Cell Stem Cell
Summary Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF p