A Potent Recombinant Polyclonal Antibody Therapeutic for Protection Against New Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern

Autor: Nicholas P Wayham, Ariel R Niedecken, Jan Fredrik Simons, Yao Y Chiang, Angélica V Medina-Cucurella, Rena A Mizrahi, Ellen K Wagner, Ashley Gras, Ilana Segal, Peyton Witte, Alexis Enstrom, Aristea Bountouvas, Sabrina M Nelson, Tess Weinberger, David Tan, Michael A Asensio, Alagu Subramanian, Yoong Wearn Lim, Adam S Adler, Sheila M Keating

Publikováno v: The Journal of Infectious Diseases.

Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) possess mutations that prevent antibody therapeutics from maintaining antiviral binding and neutralizing efficacy. Monoclonal antibodies (mAbs) shown to neutralize Wuha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2bfb36483accb547c694e3d560f93c3
https://doi.org/10.1093/infdis/jiad102

Sequencing the B Cell Receptor Repertoires of Antibody-Deficient Individuals With and Without Infection Susceptibility.

Autor: Lim YW; GigaGen, Inc. (A Grifols Company), San Carlos, CA, USA., Ramirez NJ; Institute for Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany., Asensio MA; GigaGen, Inc. (A Grifols Company), San Carlos, CA, USA., Chiang Y; GigaGen, Inc. (A Grifols Company), San Carlos, CA, USA., Müller G; Institute for Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany., Mrovecova P; Institute for Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany., Mitsuiki N; Institute for Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Department of Pediatrics and Developmental Biology, Graduate School of Medical Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Krausz M; Institute for Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Department of Rheumatology and Clinical Immunology, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany., Camacho-Ordonez N; Institute for Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Department of Rheumatology and Clinical Immunology, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Faculty of Biology, Albert-Ludwigs University, Freiburg, Germany., Warnatz K; Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany.; Department of Rheumatology and Clinical Immunology, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany., Adler AS; GigaGen, Inc. (A Grifols Company), San Carlos, CA, USA. adam.adler@grifols.com., Grimbacher B; Institute for Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany. bodo.grimbacher@uniklinik-freiburg.de.; Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany. bodo.grimbacher@uniklinik-freiburg.de.; Department of Rheumatology and Clinical Immunology, Medical Center, Faculty of Medicine, Albert-Ludwigs University, Freiburg, Germany. bodo.grimbacher@uniklinik-freiburg.de.; DZIF - German Center for Infection Research, Satellite Center Freiburg, Freiburg im Breisgau, Germany. bodo.grimbacher@uniklinik-freiburg.de.; CIBSS - Centre for Integrative Biological Signalling Studies, Albert-Ludwigs University, Freiburg, Germany. bodo.grimbacher@uniklinik-freiburg.de.; RESIST - Cluster of Excellence 2155 to Hanover Medical School, Satellite Center, Freiburg, Germany. bodo.grimbacher@uniklinik-freiburg.de.

Publikováno v: Journal of clinical immunology [J Clin Immunol] 2023 Jul; Vol. 43 (5), pp. 940-950. Date of Electronic Publication: 2023 Feb 24.

Generation of recombinant hyperimmune globulins from diverse B-cell repertoires.

Autor: Keating SM; GigaGen Inc., South San Francisco, CA, USA., Mizrahi RA; GigaGen Inc., South San Francisco, CA, USA., Adams MS; GigaGen Inc., South San Francisco, CA, USA.; Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA., Asensio MA; GigaGen Inc., South San Francisco, CA, USA., Benzie E; GigaGen Inc., South San Francisco, CA, USA., Carter KP; GigaGen Inc., South San Francisco, CA, USA., Chiang Y; GigaGen Inc., South San Francisco, CA, USA., Edgar RC; GigaGen Inc., South San Francisco, CA, USA., Gautam BK; GigaGen Inc., South San Francisco, CA, USA., Gras A; GigaGen Inc., South San Francisco, CA, USA., Leong J; GigaGen Inc., South San Francisco, CA, USA., Leong R; GigaGen Inc., South San Francisco, CA, USA., Lim YW; GigaGen Inc., South San Francisco, CA, USA., Manickam VA; GigaGen Inc., South San Francisco, CA, USA., Medina-Cucurella AV; GigaGen Inc., South San Francisco, CA, USA., Niedecken AR; GigaGen Inc., South San Francisco, CA, USA., Saini J; GigaGen Inc., South San Francisco, CA, USA., Simons JF; GigaGen Inc., South San Francisco, CA, USA., Spindler MJ; GigaGen Inc., South San Francisco, CA, USA., Stadtmiller K; GigaGen Inc., South San Francisco, CA, USA., Tinsley B; GigaGen Inc., South San Francisco, CA, USA., Wagner EK; GigaGen Inc., South San Francisco, CA, USA., Wayham N; GigaGen Inc., South San Francisco, CA, USA., Tracy L; PHASTAR, Inc., San Diego, CA, USA., Lundberg CV; Statens Serum Institut, Copenhagen, Denmark., Büscher D; Grifols S.A., Sant Cugat del Vallès, Spain., Terencio JV; Grifols S.A., Sant Cugat del Vallès, Spain., Roalfe L; Immunobiology Section, Great Ormond Street Institute of Child Health, University College London, London, England., Pearce E; Immunobiology Section, Great Ormond Street Institute of Child Health, University College London, London, England., Richardson H; Immunobiology Section, Great Ormond Street Institute of Child Health, University College London, London, England., Goldblatt D; Immunobiology Section, Great Ormond Street Institute of Child Health, University College London, London, England., Ramjag AT; Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, St. Augustine, Trinidad and Tobago., Carrington CVF; Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, St. Augustine, Trinidad and Tobago., Simmons G; Vitalant Research Institute, San Francisco, CA, USA., Muench MO; Vitalant Research Institute, San Francisco, CA, USA., Chamow SM; Chamow & Associates, Inc., San Mateo, CA, USA., Monroe B; Chamow & Associates, Inc., San Mateo, CA, USA., Olson C; Chamow & Associates, Inc., San Mateo, CA, USA., Oguin TH; Regional Biocontainment Laboratory, Duke University Medical Center, Durham, NC, USA., Lynch H; Regional Biocontainment Laboratory, Duke University Medical Center, Durham, NC, USA., Jeanfreau R; MedPharmics, Inc., Metairie, LA, USA., Mosher RA; Waisman Biomanufacturing, University of Wisconsin, Madison, WI, USA., Walch MJ; Waisman Biomanufacturing, University of Wisconsin, Madison, WI, USA., Bartley CR; Waisman Biomanufacturing, University of Wisconsin, Madison, WI, USA., Ross CA; Waisman Biomanufacturing, University of Wisconsin, Madison, WI, USA., Meyer EH; Stanford Diabetes Research Center, Stanford University Medical Center, Stanford, CA, USA.; Stanford Cancer Institute, Stanford University Medical Center, Stanford, CA, USA., Adler AS; GigaGen Inc., South San Francisco, CA, USA., Johnson DS; GigaGen Inc., South San Francisco, CA, USA. djohnson@gigagen.com.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2021 Aug; Vol. 39 (8), pp. 989-999. Date of Electronic Publication: 2021 Apr 15.

A Bump-Hole Approach for Directed RNA Editing.

Autor: Monteleone LR; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA., Matthews MM; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA., Palumbo CM; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA., Thomas JM; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA., Zheng Y; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA., Chiang Y; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA., Fisher AJ; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA; Department of Molecular and Cellular Biology, University of California, One Shields Avenue, Davis, CA 95616, USA., Beal PA; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA. Electronic address: pabeal@ucdavis.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2019 Feb 21; Vol. 26 (2), pp. 269-277.e5. Date of Electronic Publication: 2018 Dec 20.