Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Yao‐Qing Chen"'
Autor:
Xinyu Yue, Cailing Zhong, Rui Cao, Sizhe Liu, Zhiran Qin, Lin Liu, Yanmei Zhai, Wanyu Luo, Yikai Lian, Mengjie Zhang, Hongjie Lu, Yuanyuan Wang, Mengxin Xu, Shuning Liu, Kexin Lv, Yuzhu Sun, Xingchen Zhu, Haoting Mai, Jing Liao, Jingyi Yang, Lei Deng, Yang Liu, Caijun Sun, Ke-Wei Zheng, Yuelong Shu, Yao-Qing Chen
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Developing broad-spectrum influenza vaccines is crucial for influenza control and potential pandemic preparedness. Here, we reported a novel vaccine design utilizing circular RNA (circRNA) as a delivery platform for multi-subtype neuraminida
Externí odkaz:
https://doaj.org/article/3b33c6f066214697a0b41828305ef925
Autor:
Shengjun Wang, Wei Ran, Lingyu Sun, Qingchi Fan, Yuanqi Zhao, Bowen Wang, Jinghong Yang, Yuqi He, Ying Wu, Yuanyuan Wang, Luoyi Chen, Arpaporn Chuchuay, Yuyu You, Xinhai Zhu, Xiaojuan Wang, Ye Chen, Yanqun Wang, Yao-Qing Chen, Yanqiu Yuan, Jincun Zhao, Yang Mao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The multibasic furin cleavage site at the S1/S2 boundary of the spike protein is a hallmark of SARS-CoV-2 and plays a crucial role in viral infection. However, the mechanism underlying furin activation and its regulation remain poorly unders
Externí odkaz:
https://doaj.org/article/7db3930eb94b4fa9b117d83986ce71a3
Autor:
Xian Li, Mengxin Xu, Jingyi Yang, Li Zhou, Lin Liu, Min Li, Shasha Wang, Mei-Qin Liu, Zhixiang Huang, Zhen Zhang, Shuning Liu, Yunqi Hu, Haofeng Lin, Bowen Liu, Ying Sun, Qingguo Wu, Zheng-Li Shi, Ke Lan, Yu Chen, Huimin Yan, Yao-Qing Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic. Here, we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain (R
Externí odkaz:
https://doaj.org/article/b7066e2f718942a8a2557676dfdd8e3a
Autor:
Jing Wang, Yuan-fei Pan, Li-fen Yang, Wei-hong Yang, Kexin Lv, Chu-ming Luo, Juan Wang, Guo-peng Kuang, Wei-chen Wu, Qin-yu Gou, Gen-yang Xin, Bo Li, Huan-le Luo, Shoudeng Chen, Yue-long Shu, Deyin Guo, Zi-Hou Gao, Guodong Liang, Jun Li, Yao-qing Chen, Edward C. Holmes, Yun Feng, Mang Shi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection and spillover among them. We char
Externí odkaz:
https://doaj.org/article/0aa4b0f1af894e22a57abc32c9a8a956
Autor:
Guoqin Mai, Chi Zhang, Chunhong Lan, Jie Zhang, Yuanyuan Wang, Kang Tang, Jing Tang, Jinfeng Zeng, Yilin Chen, Peiwen Cheng, Shuning Liu, Haoyu Long, Qilan Wen, Aqin Li, Xuan Liu, Ruitong Zhang, Shuyang Xu, Lin Liu, Yanlan Niu, Lan Yang, Yihan Wang, Di Yin, Caijun Sun, Yao-Qing Chen, Wei Shen, Zhenhai Zhang, Xiangjun Du
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Yearly epidemics of seasonal influenza cause an enormous disease burden around the globe. An understanding of the rules behind the immune response with repeated vaccination still presents a significant challenge, which would be helpful for optimizin
Externí odkaz:
https://doaj.org/article/63c2942407c346ce893a905e4afa9666
Autor:
Li-Qian Chen, Zhang Zhang, Hong-Xuan Chen, Jian-Fei Xi, Xue-Hong Liu, Dong-Zhao Ma, Yu-Hao Zhong, Wen Hui Ng, Tao Chen, Daniel W. Mak, Qi Chen, Yao-Qing Chen, Guan-Zheng Luo
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract N 6-deoxyadenosine methylation (6mA) is the most widespread type of DNA modification in prokaryotes and is also abundantly distributed in some unicellular eukaryotes. However, 6mA levels are remarkably low in mammals. The lack of a precise a
Externí odkaz:
https://doaj.org/article/94b9f4cbfe6a4d60a2937f9d1128ae21
Autor:
Bing He, Shuning Liu, Mengxin Xu, Yunqi Hu, Kexin Lv, Yuanyuan Wang, Yong Ma, Yanmei Zhai, Xinyu Yue, Lin Liu, Hongjie Lu, Siwei Zhou, Pengbin Li, Guoqin Mai, Xiaoping Huang, Chenhang Li, Shifeng Chen, Shupei Ye, Pingsen Zhao, Yuedong Yang, Xinhua Li, Yusheng Jie, Mang Shi, Jingyi Yang, Yuelong Shu, Yao-Qing Chen
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 2007-2020 (2022)
Dynamic changes of the paired heavy and light chain B cell receptor (BCR) repertoire provide an essential insight into understanding the humoral immune response post-SARS-CoV-2 infection and vaccination. However, differences between the endogenous pa
Externí odkaz:
https://doaj.org/article/9df9550868ad4d858e91a77ced6e4472
Autor:
Jingyi Yang, Mei-Qin Liu, Lin Liu, Xian Li, Mengxin Xu, Haofeng Lin, Min Li, Huimin Yan, Yao-Qing Chen, Zheng-Li Shi
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/064d9a79b51449928ddba45272ead7b8
Autor:
Di Yin, Zirong Han, Bing Lang, Yanjun Li, Guoqin Mai, Hongbiao Chen, Liqiang Feng, Yao-qing Chen, Huanle Luo, Yaming Xiong, Lin Jing, Xiangjun Du, Yuelong Shu, Caijun Sun
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPre-existing cross-reactive immunity among different coronaviruses, also termed immune imprinting, may have a comprehensive impact on subsequent SARS-CoV-2 infection and COVID-19 vaccination effectiveness. Here, we aim to explore the interp
Externí odkaz:
https://doaj.org/article/5f7f1f97777442b38f34b0c3bdd5eae9
Autor:
De-Jian Liu, Cui-Cui Liu, Xiu-Qin Zhong, Xuan Wu, Hui-Hui Zhang, Shang-Wen Lu, Zhuo-Ling Shen, Wen-Wen Song, Shi-Long Zhao, You-Song Peng, He-Ping Zheng, Mu-Yang Wan, Yao-Qing Chen, Lei Deng
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112766- (2023)
Summary: Neuraminidase is suggested as an important component for developing a universal influenza vaccine. Targeted induction of neuraminidase-specific broadly protective antibodies by vaccinations is challenging. To overcome this, we rationally sel
Externí odkaz:
https://doaj.org/article/bffb56e15a104568b1a4454a559d1019