Výsledky vyhledávání - "Yao‐Ling Qiu"

Preclinical Profile and Clinical Efficacy of a Novel Hepatitis C Virus NS5A Inhibitor, EDP-239

Publikováno v: Antimicrobial Agents and Chemotherapy. 60:6207-6215

EDP-239, a novel hepatitis C virus (HCV) inhibitor targeting nonstructural protein 5A (NS5A), has been investigated in vitro and in vivo . EDP-239 is a potent, selective inhibitor with potency at picomolar to nanomolar concentrations against HCV geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae405a7e03ae05d313aaeeb77cff5f5
https://doi.org/10.1128/aac.00808-16

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Synthesis of phosphonate derivatives of methylenecyclopropane nucleoside analogues by alkylation–elimination method and unusual opening of cyclopropane ring

Autor: Jiri Zemlicka, Earl R. Kern, Mohamad B. Ksebati, Hui-Ping Guan, Yao-Ling Qiu

Publikováno v: Tetrahedron. 58:6047-6059

The synthesis of phosphonates of methylenecyclopropane nucleoside analogues 15a–18a , 15b–18b and 15c–18c by alkylation–elimination approach is described. In a foreshortened series, methanesulfonate 19 was transformed by Michaelis–Becker re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbd9e46d7837b0c00fcdcb99a30345f7
https://doi.org/10.1016/s0040-4020(02)00589-6

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Covalently cross-linked Watson–Crick base pair models. Part 2

Autor: George Topalov, Yoshito Kishi, Yao Ling Qiu, Hong Yu Li

Publikováno v: Tetrahedron Letters. 41:9425-9429

A concise and practical route has been developed for a synthesis of the CH 2 -bridged base pairs represented by the type- II structure. The structural studies suggest the possibility that these base pairs mimic the molecular architecture of Watson–

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75e9fd08d8e770cb0fbb7ee51abf8399
https://doi.org/10.1016/s0040-4039(00)01572-0

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In Vitro Activities of Methylenecyclopropane Analogues of Nucleosides and Their Phosphoralaninate Prodrugs against Cytomegalovirus and Other Herpesvirus Infections

Autor: Yao-Ling Qiu, Jean-Pierre Sommadossi, Jiri Zemlicka, Emma A. Harden, Rachel J. Rybak, Caroll B. Hartline, Earl R. Kern, Gwen Marshall

Publikováno v: Antimicrobial Agents and Chemotherapy. 44:1506-1511

Human cytomegalovirus (HCMV) infection does not generally cause problems in the immunocompetent adult but can result in severe clinical disease in the fetus, neonate, and immunocompromised host. Ganciclovir (GCV), the agent currently used to treat mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bd683adba25ccdadb19d351456ea7b
https://doi.org/10.1128/aac.44.6.1506-1511.2000

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In Vitro Induction of Human Immunodeficiency Virus Type 1 Variants Resistant to Phosphoralaninate Prodrugs of Z -Methylenecyclopropane Nucleoside Analogues

Autor: Mark F. Kavlick, Kazuhisa Yoshimura, Eiichi Kodama, Ron J. Feldman, Yao Ling Qiu, Jiri Zemlicka, Hiroaki Mitsuya

Publikováno v: Antimicrobial Agents and Chemotherapy. 43:2479-2483

To date, a number of nucleoside reverse transcriptase (RT) inhibitors have been developed for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection. However, the accumulation of data suggests that the development of HIV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277a985f073f181f73cd95e97ace9ea3
https://doi.org/10.1128/aac.43.10.2479

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Synthesis and antiviral activity of phosphoralaninate derivatives of methylenecyclopropane analogues of nucleosides

Autor: Yao-Ling Qiu, Yung-Chi Cheng, Earl R. Kern, Roger G. Ptak, John C. Drach, Julie M. Breitenbach, Ju-Sheng Lin, Jiri Zemlicka

Publikováno v: Antiviral Research. 43:37-53

Phenylmethylphosphoro-L-alaninate prodrugs of antiviral Z-methylenecyclopropane nucleoside analogues and their inactive E-isomers were synthesized and evaluated for their antiviral activity against HCMV, HSV-1, HSV-2, HHV-6, EBV, VZV, HIV-1 and HBV.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77194056d480bc6ccf78b2e324ffeda
https://doi.org/10.1016/s0166-3542(99)00029-7

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