Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Yao‐Hsiang Shih"'
Autor:
Pei‐Wen Lin, Man‐Ling Chu, Yu‐Wen Liu, Yu‐Cing Chen, Yao‐Hsiang Shih, Sheng‐Hui Lan, Shang‐Ying Wu, I‐Ying Kuo, Hong‐Yi Chang, Hsiao‐Sheng Liu, Ying‐Ray Lee
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 7, Pp 642-649 (2024)
Abstract Autophagy can be classified as degradative and secretory based on distinct functions. The small GTPase proteins Rab8a and Rab37 are responsible for secretory autophagy‐mediated exocytosis of IL‐1β, insulin, and TIMP1 (tissue inhibitor o
Externí odkaz:
https://doaj.org/article/e258c7ae7ddd4ed3a3137a5a976dbe9c
Autor:
Yao-Hsiang Shih, Ling-Hsien Tu, Ting-Yu Chang, Kiruthika Ganesan, Wei-Wei Chang, Pao-Sheng Chang, Yu-Sheng Fang, Yeh-Tung Lin, Lee-Way Jin, Yun-Ru Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
TDP-43 inclusions are observed in Alzheimer’s disease. Here the authors show that TDP-43 interacts with amyloid-β and inhibits fibrillization in vitro and exacerbates Alzheimer’s disease pathology in animal models.
Externí odkaz:
https://doaj.org/article/a3987a249bec4a6a993488d9681fbc13
Autor:
Yu-Hao Lin, Yao-Hsiang Shih, Ye Vone Yap, Yen-Wei Chen, Hsiang-Lin Kuo, Tsung-Yun Liu, Li-Jin Hsu, Yu-Min Kuo, Nan-Shan Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14510 (2022)
When WWOX is downregulated in middle age, aggregation of a protein cascade, including TRAPPC6AΔ (TPC6AΔ), TIAF1, and SH3GLB2, may start to occur, and the event lasts more than 30 years, which results in amyloid precursor protein (APP) degradation,
Externí odkaz:
https://doaj.org/article/0616ab28fc244dd4abf43e1a6b362a56
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5531 (2022)
Hypertension is associated with blood-brain barrier alteration and brain function decline. Previously, we established the 2-kidney,1-clip (2K1C) hypertensive mice model by renin-angiotensin system (RAS) stimulating. We found that 2K1C-induced hyperte
Externí odkaz:
https://doaj.org/article/aafba6bdf2134f7d91bfd9d55d4b976f
Autor:
Yao-Hsiang Shih, Shih-Ying Wu, Megan Yu, Sheng-Huai Huang, Chu-Wan Lee, Meei-Jyh Jiang, Pao-Yen Lin, Ting-Ting Yang, Yu-Min Kuo
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Epidemiological studies suggest there is an association between midlife hypertension and increased risk of late-life Alzheimer’s disease (AD). However, whether hypertension accelerates the onset of AD or is a distinct disease that becomes more prev
Externí odkaz:
https://doaj.org/article/914c9e57110f499981d720da1bfb1f6c
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33120 (2012)
Accumulation of amyloid-β (Aβ) peptides in the brain is one of the central pathogenic events in Alzheimer's disease (AD). However, why and how Aβ aggregates within the brain of AD patients remains elusive. Previously, we demonstrated hemoglobin (H
Externí odkaz:
https://doaj.org/article/fb854b000de24d79a0b814669438f0d7
Publikováno v:
ACS Applied Nano Materials. 6:4957-4968
Publikováno v:
IEEE transactions on bio-medical engineering.
To identify the turbulent components of blood flow facilitating aortic lumen dilatation in a post-stenotic dilatation (PSD) porcine model.The porcine abdominal aorta (AA) was moderately coarctated to induce overt flow turbulence in the downstream reg
Autor:
Yun-Ru Chen, Lee-Way Jin, Yu Sheng Fang, Yao Hsiang Shih, Ling Hsien Tu, Wei Wei Chang, Yeh Tung Lin, Kiruthika Ganesan, Pao Sheng Chang, Ting Yu Chang
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
TDP-43 inclusions are found in many Alzheimer’s disease (AD) patients presenting faster disease progression and greater brain atrophy. Previously, we showed full-length TDP-43 forms spherical oligomers and perturbs amyloid-β (Aβ) fibrillization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4187131f111a6378df3c13344a8d36c5
https://ora.ox.ac.uk/objects/uuid:fb36f9aa-6fd0-4b55-b6a0-09c5d1ec070c
https://ora.ox.ac.uk/objects/uuid:fb36f9aa-6fd0-4b55-b6a0-09c5d1ec070c
Autor:
Hsiu Fang Fan, Cai Ling Shen, Han Chen Lin, Jian Wei Huang, Kai Wei Hu, Yao Hsiang Shih, Yu Chieh Chen, Ling Hsien Tu
Publikováno v:
The journal of physical chemistry. B. 125(21)
Alzheimer's disease (AD) is characterized by the presence of extracellular senile plaques formed by β-amyloid (Aβ) peptides in the patient's brain. Previous studies have shown that the plaques in the AD brains are colocalized with the advanced glyc