Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

Autor: Belk, Julia A., Yao, Winnie, Ly, Nghi, Freitas, Katherine A., Chen, Yan-Ting, Shi, Quanming, Valencia, Alfredo M., Shifrut, Eric, Kale, Nupura, Yost, Kathryn E., Duffy, Connor V., Daniel, Bence, Hwee, Madeline A., Miao, Zhuang, Ashworth, Alan, Mackall, Crystal L., Marson, Alexander, Carnevale, Julia, Vardhana, Santosh A., Satpathy, Ansuman T.

Publikováno v: In Cancer Cell 11 July 2022 40(7):768-786

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Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion.

Autor: Cohen Shvefel S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Pai JA; Department of Pathology, Stanford University, Stanford, CA, USA., Cao Y; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Pal LR; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Levy R; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Yao W; Department of Pathology, Stanford University, Stanford, CA, USA., Cheng K; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.; MSD R&D (China) Co., Ltd., Zemanek M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Bartok O; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Weller C; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Yin Y; Department of Pathology, Stanford University, Stanford, CA, USA., Du PP; Department of Pathology, Stanford University, Stanford, CA, USA., Yakubovich E; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Orr I; Bioinformatics Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Ben-Dor S; Bioinformatics Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Oren R; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Fellus-Alyagor L; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Golani O; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Goliand I; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Ranmar D; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Savchenko I; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Ketrarou N; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Schäffer AA; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Ruppin E; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Satpathy AT; Department of Pathology, Stanford University, Stanford, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Samuels Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 29. Date of Electronic Publication: 2023 Nov 29.