Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors

Autor: Jhajj, Harkamal S., Schardt, John S., Khalasawi, Namir, Yao, Emily L., Lwo, Timon S., Kwon, Na-Young, O’Meara, Ryen L., Desai, Alec A., Tessier, Peter M.

Publikováno v: In Cell Chemical Biology 16 May 2024 31(5):944-954

Facile generation of biepitopic antibodies with intrinsic agonism for activating receptors in the tumor necrosis factor superfamily.

Autor: Jhajj HS; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Schardt JS; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Khalasawi N; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Yao EL; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Lwo TS; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Kwon NY; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., O'Meara RL; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Desai AA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Tessier PM; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 12. Date of Electronic Publication: 2023 Dec 12.